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D57.41 ICD-10-CM Code: Sickle-cell thalassemia, unspecified, with crisis

Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.

Official Registry Overview & Definition

Sickle-cell thalassemia, unspecified, with crisis is a non-billable ICD-10-CM category code (D57.41). A more specific billable subcode must be selected for claims submission.

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for D57.41 in the official ICD-10-CM tabular list.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Sickle-cell thalassemia with (painful) crisis NOS
  • Sickle-cell thalassemia with (vaso-occlusive) pain NOS

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code for any associated fever (R50.81)

Frequently Compared Codes

The official Excludes notes on D57.41 name these codes. Each comparison page covers when the two can — or must not — be reported together.

Change history

  • FY2021 — 2020-10-01
    Description revised
    Sickle-cell thalassemia with crisis → Sickle-cell thalassemia, unspecified, with crisis
    FY2021 changes
  • FY2021 — 2020-10-01
    Short description revised
    Sickle-cell thalassemia with crisis → Sickle-cell thalassemia, unspecified, with crisis
    FY2021 changes

Verify Before Coding

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Referenced by Other Codes

Official ICD-10-CM tabular notes on other codes that name D57.41 or its code family.

4 Excludes1 notes: D56 (via D57.4.-), D56.1 (via D57.4.-), D56.5 (via D57.4.-), D56.8 (via D57.-).

3 Code First instructions across 3 chapters: H36 (via D57.-), M14.8 (via D57.-), R50.81 (via D57.-).

1 Code Also instructions: Z71.87 (via D57.-).

Contextual Map

Every relationship of D57.41 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

  • D50-D89 — Chapter 3: Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) (D50-D89) [Hierarchy]

Referenced by Excludes1 notes

  • D56 — Thalassemia [Excludes1](via D57.4.-): “sickle-cell thalassemia (D57.4-)” · check together
  • D56.1 — Beta thalassemia [Excludes1](via D57.4.-): “sickle-cell beta thalassemia (D57.4-)” · check together
  • D56.5 — Hemoglobin E-beta thalassemia [Excludes1](via D57.4.-): “sickle-cell beta thalassemia (D57.4-)” · check together
  • D56.8 — Other thalassemias [Excludes1](via D57.-): “sickle-cell anemia (D57.-)” · check together

Referenced by Code First instructions

  • H36 — Retinal disorders in diseases classified elsewhere [Code First](via D57.-): “sickle-cell disorders (D57.-)” · check together
  • M14.8 — Arthropathies in other specified diseases classified elsewhere [Code First](via D57.-): “sickle-cell disorders (D57.-)” · check together
  • R50.81 — Fever presenting with conditions classified elsewhere [Code First](via D57.-): “sickle-cell disease (D57.-)” · check together

Referenced by Code Also instructions

  • Z71.87 — Encounter for pediatric-to-adult transition counseling [Code Also](via D57.-): “sickle-cell disorder (D57.-)” · check together

Nearest codes (40)

  • D57 — Sickle-cell disorders [Sibling]
  • D57.0 — Hb-SS disease with crisis [Sibling]
  • D57.00 — Hb-SS disease with crisis, unspecified [Sibling]
  • D57.01 — Hb-SS disease with acute chest syndrome [Sibling]
  • D57.02 — Hb-SS disease with splenic sequestration [Sibling]
  • D57.03 — Hb-SS disease with cerebral vascular involvement [Sibling]
  • D57.04 — Hb-SS disease with dactylitis [Sibling]
  • D57.09 — Hb-SS disease with crisis with other specified complication [Sibling]
  • and 32 more

Change history (2)

  • FY2021 — Description revised [Change history]
  • and 1 more

Frequently Asked Questions (FAQ) & Clinical Guidance

Can D57.41 be billed directly?

No. D57.41 (Sickle-cell thalassemia, unspecified, with crisis) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to D57.41 in its code family, with their registry titles.

  • D57.218 — Sickle-cell/Hb-C disease with crisis with other specified complication
  • D57.219 — Sickle-cell/Hb-C disease with crisis, unspecified
  • D57.3 — Sickle-cell trait
  • D57.4 — Sickle-cell thalassemia
  • D57.40 — Sickle-cell thalassemia without crisis
  • D57.411 — Sickle-cell thalassemia, unspecified, with acute chest syndrome
  • D57.412 — Sickle-cell thalassemia, unspecified, with splenic sequestration
  • D57.413 — Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
  • D57.414 — Sickle-cell thalassemia, unspecified, with dactylitis
  • D57.418 — Sickle-cell thalassemia, unspecified, with crisis with other specified complication

View all codes in the D57 family