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D57.45 ICD-10-CM Code: Sickle-cell thalassemia beta plus with crisis

Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.

Code Overview

Sickle-cell thalassemia beta plus with crisis is a non-billable ICD-10-CM category code (D57.45). A more specific billable subcode must be selected for claims submission.

Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for D57.45 in the official ICD-10-CM tabular list.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • HbS-beta plus with crisis
  • Sickle-cell beta plus with crisis

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code for any associated fever (R50.81) inherited from D57

Frequently Compared Codes

The official Excludes notes on D57.45 name these codes. Each comparison page covers when the two can — or must not — be reported together.

Change history

  • FY2021 — 2020-10-01
    Added to the code set
    Sickle-cell thalassemia beta plus with crisis
    FY2021 changes

Verify Before Coding

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

Other codes that name D57.45 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 4 Excludes1 notes: D56 (via D57.4.-), D56.1 (via D57.4.-), D56.5 (via D57.4.-), D56.8 (via D57.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 3 Code First instructions across 3 chapters: H36 (via D57.-), M14.8 (via D57.-), R50.81 (via D57.-).

These codes instruct coders to sequence this condition first when it applies.

Referenced by 1 Code Also instruction: Z71.87 (via D57.-).

These codes suggest coding this condition alongside when both are present.

Contextual Map

Every relationship of D57.45 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

  • D50-D89 — Chapter 3: Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) (D50-D89) [Hierarchy]

Referenced by Excludes1 notes

  • D56 — Thalassemia [Excludes1](via D57.4.-): “sickle-cell thalassemia (D57.4-)” · check together
  • D56.1 — Beta thalassemia [Excludes1](via D57.4.-): “sickle-cell beta thalassemia (D57.4-)” · check together
  • D56.5 — Hemoglobin E-beta thalassemia [Excludes1](via D57.4.-): “sickle-cell beta thalassemia (D57.4-)” · check together
  • D56.8 — Other thalassemias [Excludes1](via D57.-): “sickle-cell anemia (D57.-)” · check together

Referenced by Code First instructions

  • H36 — Retinal disorders in diseases classified elsewhere [Code First](via D57.-): “sickle-cell disorders (D57.-)” · check together
  • M14.8 — Arthropathies in other specified diseases classified elsewhere [Code First](via D57.-): “sickle-cell disorders (D57.-)” · check together
  • R50.81 — Fever presenting with conditions classified elsewhere [Code First](via D57.-): “sickle-cell disease (D57.-)” · check together

Referenced by Code Also instructions

  • Z71.87 — Encounter for pediatric-to-adult transition counseling [Code Also](via D57.-): “sickle-cell disorder (D57.-)” · check together

Nearest codes (40)

  • D57 — Sickle-cell disorders [Sibling]
  • D57.211 — Sickle-cell/Hb-C disease with acute chest syndrome [Sibling]
  • D57.212 — Sickle-cell/Hb-C disease with splenic sequestration [Sibling]
  • D57.213 — Sickle-cell/Hb-C disease with cerebral vascular involvement [Sibling]
  • D57.214 — Sickle-cell/Hb-C disease with dactylitis [Sibling]
  • D57.218 — Sickle-cell/Hb-C disease with crisis with other specified complication [Sibling]
  • D57.219 — Sickle-cell/Hb-C disease with crisis, unspecified [Sibling]
  • D57.3 — Sickle-cell trait [Sibling]
  • and 32 more

Change history

  • FY2021 — Added to the code set [Change history]

Frequently Asked Questions (FAQ) & Clinical Guidance

Can D57.45 be billed directly?

No. D57.45 (Sickle-cell thalassemia beta plus with crisis) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to D57.45 in its code family, with their registry titles.

  • D57.433 — Sickle-cell thalassemia beta zero with cerebral vascular involvement
  • D57.434 — Sickle-cell thalassemia beta zero with dactylitis
  • D57.438 — Sickle-cell thalassemia beta zero with crisis with other specified complication
  • D57.439 — Sickle-cell thalassemia beta zero with crisis, unspecified
  • D57.44 — Sickle-cell thalassemia beta plus without crisis
  • D57.451 — Sickle-cell thalassemia beta plus with acute chest syndrome
  • D57.452 — Sickle-cell thalassemia beta plus with splenic sequestration
  • D57.453 — Sickle-cell thalassemia beta plus with cerebral vascular involvement
  • D57.454 — Sickle-cell thalassemia beta plus with dactylitis
  • D57.458 — Sickle-cell thalassemia beta plus with crisis with other specified complication

View all codes in the D57 family