D57.45 (Sickle-cell thalassemia beta plus with crisis) compared with D58 (Other hereditary hemolytic anemias), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Not coded here — these two are mutually exclusive.
“other hemoglobinopathies (D58.-)”
An Excludes1 note means the two conditions cannot occur together, so the pair should not be reported for the same encounter. The sole exception is when the conditions are documented as unrelated to each other.
Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a
No — do not report together. D57.45 carries an Excludes1 note covering D58: “other hemoglobinopathies (D58.-)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
| D57.45Sickle-cell thalassemia beta plus with crisis | D58Other hereditary hemolytic anemias | |
|---|---|---|
| Billing status | Non-billable header | Non-billable header |
| Classification | D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) | D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) |
| Definition | Sickle-cell thalassemia beta plus with crisis is a non-billable ICD-10-CM category code (D57.45). | Other hereditary hemolytic anemias is a non-billable ICD-10-CM category code (D58). |
| Includes | HbS-beta plus with crisis Sickle-cell beta plus with crisis | — |
| Use additional code | code for any associated fever (R50.81) | — |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources