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D58.2 ICD-10-CM Code: Other hemoglobinopathies

Compare with another code for D58.2Check this code on a claim

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Official instructions
7 inclusion terms · 8 Excludes1
Risk adjustment
CMS-HCC V22 category 48

What these terms mean →

Billable · FY2027A valid, specific ICD-10-CM code, reportable for dates of service in FY2027.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too, and is marked with where it comes from.

Excludes1Not reported with this code unless documented as unrelated
  • familial polycythemia (D75.0)
  • Hb-M disease (D74.0)
  • hemoglobin E-beta thalassemia (D56.5)
  • hereditary persistence of fetal hemoglobin HPFH

+4 more in Instructions

IncludesWhat this code covers
  • Abnormal hemoglobin NOS
  • Congenital Heinz body anemia
  • Hb-C disease
  • Hb-D disease

+3 more in Instructions

Where it sits Source: CMS/NCHS

Under:Chapter 3: Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune MechanismD55-D59 Hemolytic anemiasD58 Other hereditary hemolytic anemias

Most relevant related codes MedCoder-derived

Read off the official notes above and this code’s own position in the tabular list. Which to report is a documentation question; Compare shows the two side by side.

CompareCheck ClaimView Related Codes

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 811 — RED BLOOD CELL DISORDERS WITH MCC (MDC 16)
  • MS-DRG 812 — RED BLOOD CELL DISORDERS WITHOUT MCC (MDC 16)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for D58.2 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Notes without a marker are published on D58.2 itself; “inherited from” names the category or block whose note applies here.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Abnormal hemoglobin NOS
  • Congenital Heinz body anemia
  • Hb-C disease
  • Hb-D disease
  • Hb-E disease
  • Hemoglobinopathy NOS
  • Unstable hemoglobin hemolytic disease

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Coder workflow for D58.2

MedCoder structured workflow — derived from this code’s own official record

Before you code D58.2

  1. “Other” (NEC) means the condition is specified in the record but no dedicated code captures it. Confirm the documented form is not one a sibling code names before settling on D58.2; if the record states no specifics at all, the unspecified sibling applies instead. “Other” codes are for documented conditions the classification gives no specific code; “unspecified” codes are for records lacking the detail (Guidelines I.A.9.a, I.A.9.b).

    ReviewD58.0, D58.1

    See the relationships section · Guide: Other vs unspecified (NEC vs NOS) →

  2. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with D58.2. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support a condition named in D58.2’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewD75.0, D74.0, D56.5, D75.1, D74, D56.8

Consider D58.2. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
Any detail beyond this code’s title
What the record states that a more specific code would capture — or its absence, which itself supports the unspecified code.

Official instructions as workflow

  • Excludes1 — check before selecting D58.2(8 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with D58.2: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareD75.0, D74.0, D56.5, D75.1, D74, D56.8

    See the official tabular notes · Guidelines I.A.12.a

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition D58.2 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewD75.0, D74.0, D56.5, D75.1, D74, D56.8

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Don’t confuse D58.2 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of D58.2 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • D75.0— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of familial polycythemia moves the case to D75.0; the two are not reported together unless documented as unrelated.

    Full comparison: D58.2 vs D75.0 →

  • D74.0— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of Hb-M disease moves the case to D74.0; the two are not reported together unless documented as unrelated.

    Full comparison: D58.2 vs D74.0 →

  • D56.5— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of hemoglobin E-beta thalassemia moves the case to D56.5; the two are not reported together unless documented as unrelated.

    Full comparison: D58.2 vs D56.5 →

  • D75.1— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of high-altitude polycythemia moves the case to D75.1; the two are not reported together unless documented as unrelated.

    Full comparison: D58.2 vs D75.1 →

  • D74— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of Hb-M disease moves the case to D74; the two are not reported together unless documented as unrelated.

    Full comparison: D58.2 vs D74 →

  • D56.8— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of other hemoglobinopathies with thalassemia moves the case to D56.8; the two are not reported together unless documented as unrelated.

    Full comparison: D58.2 vs D56.8 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Other hemoglobinopathies is a billable ICD-10-CM diagnosis code (D58.2).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Official Coding Guidelines

No excerpt in the ICD-10-CM Official Guidelines names this code specifically. Its chapter carries only this chapter-wide note:

Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Reserved for future guideline expansion

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name D58.2 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 17 Excludes1 notes across 3 chapters: D56.5 — Hemoglobin E-beta thalassemia, D56.8 — Other thalassemias, D57 — Sickle-cell disorders (via D58.-), P50 — Newborn affected by intrauterine (fetal) blood loss (via D58.-), P50-P61 — Hemorrhagic and hematological disorders of newborn (P50-P61) (via D58.-), P51 — Umbilical hemorrhage of newborn (via D58.-), P52 — Intracranial nontraumatic hemorrhage of newborn (via D58.-), P53 — Hemorrhagic disease of newborn (via D58.-), P54 — Other neonatal hemorrhages (via D58.-), P55 — Hemolytic disease of newborn (via D58.-), P56 — Hydrops fetalis due to hemolytic disease (via D58.-), P57 — Kernicterus (via D58.-), P58 — Neonatal jaundice due to other excessive hemolysis (via D58.-), P59 — Neonatal jaundice from other and unspecified causes (via D58.-), P60 — Disseminated intravascular coagulation of newborn (via D58.-), P61 — Other perinatal hematological disorders (via D58.-), R71 — Abnormality of red blood cells (via D58.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 24 Code First instructions across 3 chapters: I21.A1 — Myocardial infarction type 2 (via D58.-), M36.3 — Arthropathy in other blood disorders, M90.5 — Osteonecrosis in diseases classified elsewhere (via D58.-), T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics (via D58.-), T36-T39 — Antibiotics & Anti-infectives (T36-T39) (via D58.-), T36-T50 — Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances (T36-T50) (via D58.-), T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics (via D58.-), T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified (via D58.-), T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (via D58.-), T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens] (via D58.-), T40-T41 — Analgesics & Antipyretics (T40-T41) (via D58.-), T41 — Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases (via D58.-), T42 — Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (via D58.-), T42-T43 — Anticonvulsants & Psychotropics (T42-T43) (via D58.-), T43 — Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified (via D58.-), T44 — Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system (via D58.-), T44-T46 — Cardiovascular & Gastrointestinal (T44-T46) (via D58.-), T45 — Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (via D58.-), T46 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (via D58.-), T47 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal system (via D58.-), +4 more.

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 2 MS-DRGs: DRG 811 (MDC 16), DRG 812 (MDC 16).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):BLD002 — Hemolytic anemia (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Hemolytic anemia).

D56.0 — Alpha thalassemia, D56.1 — Beta thalassemia, D56.2 — Delta-beta thalassemia, D56.3 — Thalassemia minor, D56.4 — Hereditary persistence of fetal hemoglobin [HPFH], D56.5 — Hemoglobin E-beta thalassemia, D56.8 — Other thalassemias, D56.9 — Thalassemia, unspecified, D58.0 — Hereditary spherocytosis, D58.1 — Hereditary elliptocytosis, D58.8 — Other specified hereditary hemolytic anemias, D58.9 — Hereditary hemolytic anemia, unspecified, D59.0 — Drug-induced autoimmune hemolytic anemia, D59.1 — Other autoimmune hemolytic anemias, D59.10 — Autoimmune hemolytic anemia, unspecified, D59.11 — Warm autoimmune hemolytic anemia, D59.12 — Cold autoimmune hemolytic anemia, D59.13 — Mixed type autoimmune hemolytic anemia, D59.19 — Other autoimmune hemolytic anemia, D59.2 — Drug-induced nonautoimmune hemolytic anemia, +18 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Anemia”, “Hemoglobinopathy”, “Trait”, …; these codes share that main term but sit in a different category of the Tabular List.

D57 — Sickle-cell disorders (gouty, in, sickle-cell disorders), D57.1 — Sickle-cell disease without crisis (Herrick's), D57.3 — Sickle-cell trait (Hb-S), D57.40 — Sickle-cell thalassemia without crisis (microdrepanocytosis), D57.411 — Sickle-cell thalassemia, unspecified, with acute chest syndrome (sickle-cell, with thalassemia, with, acute chest syndrome), D57.412 — Sickle-cell thalassemia, unspecified, with splenic sequestration (sickle-cell, with thalassemia, with, splenic sequestration), D57.413 — Sickle-cell thalassemia, unspecified, with cerebral vascular involvement (sickle-cell, with thalassemia, with, cerebral vascular involvement), D57.414 — Sickle-cell thalassemia, unspecified, with dactylitis (sickle-cell, with thalassemia, with, crisis, with, dactylitis), D57.418 — Sickle-cell thalassemia, unspecified, with crisis with other specified complication (sickle-cell, with thalassemia, with, crisis, with, specified complication NEC), D57.419 — Sickle-cell thalassemia, unspecified, with crisis (sickle-cell, with thalassemia, with, pain), D59.0 — Drug-induced autoimmune hemolytic anemia (hemolytic, autoimmune, drug-induced), D59.10 — Autoimmune hemolytic anemia, unspecified (hemolytic, autoimmune), D59.11 — Warm autoimmune hemolytic anemia (hemolytic, warm type), D59.12 — Cold autoimmune hemolytic anemia (hemolytic, cold type), D59.13 — Mixed type autoimmune hemolytic anemia (hemolytic, mixed type), D59.19 — Other autoimmune hemolytic anemia (Lederer's), D59.2 — Drug-induced nonautoimmune hemolytic anemia (hemolytic, due to, drugs), D59.4 — Other nonautoimmune hemolytic anemias (hemolytic, toxic), D59.6 — Hemoglobinuria due to hemolysis from other external causes (hemolytic, acquired, with hemoglobinuria NEC), D59.8 — Other acquired hemolytic anemias (hemolytic, acquired, specified type NEC), +724 more

Contextual Map

Every relationship of D58.2 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run D58.2 with these 21 related codes in Claim Check

Hierarchy

Excludes1

Referenced by Excludes1 notes (17)

Referenced by Code First instructions (24)

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 16 — Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders[MDC crossing]: “Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 1,615 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Index entries (40)

  • Abnormal, abnormality, abnormalities, hemoglobin (disease)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), congenital, Heinz body[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), Heinz body, congenital[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute), in (due to), hemoglobinopathy NEC[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Arthropathy, in (due to), hemoglobinopathy NEC[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Disease, diseased, hemoglobin or Hb, abnormal NEC (mixed)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Disease, diseased, hemoglobin or Hb, C (Hb-C)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Disease, diseased, hemoglobin or Hb, C (Hb-C), with other abnormal hemoglobin NEC[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • and 32 more

Nearest codes

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Indexed Clinical Terms (40)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Coding guidelines Official source data
ICD-10-CM Official Guidelines for Coding and Reporting (FY2027), quoted by section Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "D58.2 — Other hemoglobinopathies." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/d58.2-other-hemoglobinopathies

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Other hemoglobinopathies

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to D58.2 in its code family, with their registry titles.

View all codes in the D58 family