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D59.12 ICD-10-CM Code: Cold autoimmune hemolytic anemia

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

  • MS-DRG 808 — MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITH MCC (MDC 16)
  • MS-DRG 809 — MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITH CC (MDC 16)
  • MS-DRG 810 — MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITHOUT CC/MCC (MDC 16)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

  • HCC 109 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias

Other models: CMS-HCC V22 HCC 46 · RxHCC V08 HCC 96

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for D59.12 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on D59.12 itself; “inherited from” names the category or block whose note applies here.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Chronic cold hemagglutinin disease
  • Cold agglutinin disease
  • Cold agglutinin hemoglobinuria
  • Cold type (primary) (secondary) (symptomatic) autoimmune hemolytic anemia
  • Cold type autoimmune hemolytic disease

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Source: inherited from D59.1

Coder workflow for D59.12

MedCoder structured workflow — derived from this code’s own official record

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Official instructions as workflow

  • Excludes2 — not part of D59.12(3 notes)

    Coding workflow: The conditions named in this note are not included in D59.12. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    CompareD69.41, P55, D59.6

    See the official tabular notes · Guidelines I.A.12.b

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Cold autoimmune hemolytic anemia is a billable ICD-10-CM diagnosis code (D59.12).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (13)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Official Coding Guidelines

No excerpt in the ICD-10-CM Official Guidelines names this code specifically. Its chapter carries only this chapter-wide note:

Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Reserved for future guideline expansion

Verify Before Coding

  • CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name D59.12 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 1 Excludes1 note: R71 — Abnormality of red blood cells (via D59.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 23 Code First instructions across 3 chapters: I21.A1 — Myocardial infarction type 2 (via D59.-), M90.5 — Osteonecrosis in diseases classified elsewhere (via D59.-), T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics (via D59.-), T36-T39 — Antibiotics & Anti-infectives (T36-T39) (via D59.-), T36-T50 — Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances (T36-T50) (via D59.-), T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics (via D59.-), T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified (via D59.-), T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (via D59.-), T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens] (via D59.-), T40-T41 — Analgesics & Antipyretics (T40-T41) (via D59.-), T41 — Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases (via D59.-), T42 — Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (via D59.-), T42-T43 — Anticonvulsants & Psychotropics (T42-T43) (via D59.-), T43 — Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified (via D59.-), T44 — Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system (via D59.-), T44-T46 — Cardiovascular & Gastrointestinal (T44-T46) (via D59.-), T45 — Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (via D59.-), T46 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (via D59.-), T47 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal system (via D59.-), T47-T50 — Hormones & Systemic Agents (T47-T50) (via D59.-), +3 more.

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 16 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 3 MS-DRGs: DRG 808 (MDC 16), DRG 809 (MDC 16), DRG 810 (MDC 16).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):BLD002 — Hemolytic anemia (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

D59.0 — Drug-induced autoimmune hemolytic anemia, D59.10 — Autoimmune hemolytic anemia, unspecified, D59.11 — Warm autoimmune hemolytic anemia, D59.13 — Mixed type autoimmune hemolytic anemia, D59.19 — Other autoimmune hemolytic anemia, D59.2 — Drug-induced nonautoimmune hemolytic anemia, D59.30 — Hemolytic-uremic syndrome, unspecified, D59.31 — Infection-associated hemolytic-uremic syndrome, D59.32 — Hereditary hemolytic-uremic syndrome, D59.39 — Other hemolytic-uremic syndrome, D59.4 — Other nonautoimmune hemolytic anemias, D59.5 — Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli], D59.6 — Hemoglobinuria due to hemolysis from other external causes, D59.8 — Other acquired hemolytic anemias, D59.9 — Acquired hemolytic anemia, unspecified

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Acquired Hemolytic, Aplastic, and Sideroblastic Anemias) for risk-adjusted payment.

D59.10 — Autoimmune hemolytic anemia, unspecified, D59.11 — Warm autoimmune hemolytic anemia, D59.13 — Mixed type autoimmune hemolytic anemia, D59.19 — Other autoimmune hemolytic anemia, D59.30 — Hemolytic-uremic syndrome, unspecified, D59.31 — Infection-associated hemolytic-uremic syndrome, D59.32 — Hereditary hemolytic-uremic syndrome, D59.39 — Other hemolytic-uremic syndrome, D59.4 — Other nonautoimmune hemolytic anemias, D59.5 — Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli], D59.6 — Hemoglobinuria due to hemolysis from other external causes, D59.8 — Other acquired hemolytic anemias, D59.9 — Acquired hemolytic anemia, unspecified, D60.0 — Chronic acquired pure red cell aplasia, D60.8 — Other acquired pure red cell aplasias, D60.9 — Acquired pure red cell aplasia, unspecified, D61.01 — Constitutional (pure) red blood cell aplasia, D61.02 — Shwachman-Diamond syndrome, D61.03 — Fanconi anemia, D61.09 — Other constitutional aplastic anemia, +16 more

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Hemolytic anemia).

D56.9 — Thalassemia, unspecified, D58.0 — Hereditary spherocytosis, D58.1 — Hereditary elliptocytosis, D58.2 — Other hemoglobinopathies, D58.8 — Other specified hereditary hemolytic anemias, D58.9 — Hereditary hemolytic anemia, unspecified, D59.0 — Drug-induced autoimmune hemolytic anemia, D59.1 — Other autoimmune hemolytic anemias, D59.10 — Autoimmune hemolytic anemia, unspecified, D59.11 — Warm autoimmune hemolytic anemia, D59.13 — Mixed type autoimmune hemolytic anemia, D59.19 — Other autoimmune hemolytic anemia, D59.2 — Drug-induced nonautoimmune hemolytic anemia, D59.3 — Hemolytic-uremic syndrome, D59.30 — Hemolytic-uremic syndrome, unspecified, D59.31 — Infection-associated hemolytic-uremic syndrome, D59.32 — Hereditary hemolytic-uremic syndrome, D59.39 — Other hemolytic-uremic syndrome, D59.4 — Other nonautoimmune hemolytic anemias, D59.5 — Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli], +18 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Anemia”; these codes share that main term but sit in a different category of the Tabular List.

D55.9 — Anemia due to enzyme disorder, unspecified (deficiency, enzyme), D56.1 — Beta thalassemia (Cooley's), D56.8 — Other thalassemias (microcytic, familial), D56.9 — Thalassemia, unspecified (thalassemia), D57.1 — Sickle-cell disease without crisis (Herrick's), D57.40 — Sickle-cell thalassemia without crisis (microdrepanocytosis), D58.0 — Hereditary spherocytosis (congenital, spherocytic), D58.2 — Other hemoglobinopathies (congenital, Heinz body), D58.8 — Other specified hereditary hemolytic anemias (stomatocytosis), D58.9 — Hereditary hemolytic anemia, unspecified (hemolytic), D60.0 — Chronic acquired pure red cell aplasia (aplastic, red cell, chronic), D60.1 — Transient acquired pure red cell aplasia (aplastic, red cell, transient), D60.8 — Other acquired pure red cell aplasias (aplastic, red cell, specified type NEC), D60.9 — Acquired pure red cell aplasia, unspecified (pure red cell), D61.01 — Constitutional (pure) red blood cell aplasia (Diamond-Blackfan), D61.03 — Fanconi anemia (Fanconi), D61.09 — Other constitutional aplastic anemia (aplastic, congenital), D61.1 — Drug-induced aplastic anemia (aplastic, drug-induced), D61.2 — Aplastic anemia due to other external agents (toxic), D61.3 — Idiopathic aplastic anemia (aplastic, idiopathic), +80 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Thyroid Stimulating Hormone (TSH)

Contextual Map

Every relationship of D59.12 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run D59.12 with these 9 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Code First instructions (23)

Clinical classification (CCSR)

Risk adjustment (CMS-HCC)

  • HCC 109 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias [CMS-HCC]— CMS-HCC V28 · 2026

MS-DRG Grouper

MDC crossing

  • MDC 16 — Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders[MDC crossing]: “Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 1,614 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries (13)

  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, autoimmune, cold[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, cold type (primary) (secondary) (symptomatic)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, primary, autoimmune, cold type[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, secondary, autoimmune, cold type[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), hemolytic, symptomatic, autoimmune, cold type[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Cold, agglutinin disease or hemoglobinuria (chronic)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Cold, sensitivity, auto-immune[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Disease, diseased, autoimmune NOS (systemic), hemolytic, cold type (primary) (secondary) (symptomatic)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • and 5 more

Nearest codes (18)

Change history

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Coding guidelines Official source data
ICD-10-CM Official Guidelines for Coding and Reporting (FY2026), quoted by section Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Risk adjustment Official source data
2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "D59.12 — Cold autoimmune hemolytic anemia." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/d59.12-cold-autoimmune-hemolytic-anemia

Change history

  • FY2021 — October 1, 2020
    Added to the code set
    Cold autoimmune hemolytic anemia
    FY2021 changes

Nearest Codes in This Family

Official ICD-10-CM classifications closest to D59.12 in its code family, with their registry titles.

View all codes in the D59 family