Skip to main content

D59.3 ICD-10-CM Code: Hemolytic-uremic syndrome

Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.

Coding at a Glance

Tabular directives
3 code-also instructions

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for D59.3 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Code Also

Additional codes that may be required to fully describe the encounter.

  • Code also, if applicable, any associated:
  • acute kidney failure (N17.-)
  • chronic kidney disease (N18.-)

Coder workflow for D59.3

MedCoder structured workflow — derived from this code’s own official record

Before you code D59.3

  1. D59.3 is not reportable as written. Select the more specific code beneath it that the documentation supports. Codes are reported to the highest level of specificity the classification provides (Guidelines I.B.2).

    ReviewD59.30, D59.31, D59.32, D59.39

    See the relationships section · Guide: How to choose an ICD-10-CM code →

Choose the right path

  1. Does the documentation support one of the more specific codes beneath D59.3?
    Yes → Select that code and continue the checks below on its own page.
    No → D59.3 cannot be reported as written; query for the specificity its subcategory needs.

    ReviewD59.30, D59.31, D59.32, D59.39

Consider D59.3. Then review the Code Also note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Official instructions as workflow

  • Code Also — related condition(3 notes)

    Coding workflow: Review the related condition when both are documented and the instruction applies. A Code Also note does not fix sequencing; the order follows the circumstances of the encounter.

    ReviewN17, N18

    See the official tabular notes · Guidelines I.A.17

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Hemolytic-uremic syndrome is a non-billable ICD-10-CM category code (D59.3). A more specific billable subcode must be selected for claims submission.

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Verify Before Coding

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name D59.3 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 3 Excludes1 notes across 3 chapters: D69.1 — Qualitative platelet defects, N08 — Glomerular disorders in diseases classified elsewhere, R71 — Abnormality of red blood cells (via D59.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 4 Excludes2 notes: N17 — Acute kidney failure, N17-N19 — Acute kidney failure and chronic kidney disease (N17-N19), N18 — Chronic kidney disease (CKD), N19 — Unspecified kidney failure.

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 23 Code First instructions across 3 chapters: I21.A1 — Myocardial infarction type 2 (via D59.-), M90.5 — Osteonecrosis in diseases classified elsewhere (via D59.-), T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics (via D59.-), T36-T39 — Antibiotics & Anti-infectives (T36-T39) (via D59.-), T36-T50 — Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances (T36-T50) (via D59.-), T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics (via D59.-), T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified (via D59.-), T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (via D59.-), T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens] (via D59.-), T40-T41 — Analgesics & Antipyretics (T40-T41) (via D59.-), T41 — Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases (via D59.-), T42 — Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (via D59.-), T42-T43 — Anticonvulsants & Psychotropics (T42-T43) (via D59.-), T43 — Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified (via D59.-), T44 — Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system (via D59.-), T44-T46 — Cardiovascular & Gastrointestinal (T44-T46) (via D59.-), T45 — Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (via D59.-), T46 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (via D59.-), T47 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal system (via D59.-), T47-T50 — Hormones & Systemic Agents (T47-T50) (via D59.-), +3 more.

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

Referenced by 1 Use Additional Code instruction: M31.11 — Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA].

These codes instruct coders to additionally report this code when it applies.

Clinical classification (AHRQ CCSR):BLD002 — Hemolytic anemia (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Hemolytic anemia).

D58.2 — Other hemoglobinopathies, D58.8 — Other specified hereditary hemolytic anemias, D58.9 — Hereditary hemolytic anemia, unspecified, D59.0 — Drug-induced autoimmune hemolytic anemia, D59.1 — Other autoimmune hemolytic anemias, D59.10 — Autoimmune hemolytic anemia, unspecified, D59.11 — Warm autoimmune hemolytic anemia, D59.12 — Cold autoimmune hemolytic anemia, D59.13 — Mixed type autoimmune hemolytic anemia, D59.19 — Other autoimmune hemolytic anemia, D59.2 — Drug-induced nonautoimmune hemolytic anemia, D59.30 — Hemolytic-uremic syndrome, unspecified, D59.31 — Infection-associated hemolytic-uremic syndrome, D59.32 — Hereditary hemolytic-uremic syndrome, D59.39 — Other hemolytic-uremic syndrome, D59.4 — Other nonautoimmune hemolytic anemias, D59.5 — Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli], D59.6 — Hemoglobinuria due to hemolysis from other external causes, D59.8 — Other acquired hemolytic anemias, D59.9 — Acquired hemolytic anemia, unspecified, +18 more

Contextual Map

Every relationship of D59.3 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run D59.3 with these 16 related codes in Claim Check

Hierarchy

Code Also

Referenced by Excludes1 notes

Referenced by Excludes2 notes

Referenced by Code First instructions (23)

Referenced by Use Additional Code instructions

Clinical classification (CCSR)

Nearest codes (18)

Change history (2)

Common coding questions

Can D59.3 be billed directly?

No. D59.3 (Hemolytic-uremic syndrome) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "D59.3 — Hemolytic-uremic syndrome." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/d59.3-hemolytic-uremic-syndrome

Change history

  • FY2023 — October 1, 2022
    Became a non-billable header
    FY2023 changes
  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Hemolytic-uremic syndrome

Nearest Codes in This Family

Official ICD-10-CM classifications closest to D59.3 in its code family, with their registry titles.

View all codes in the D59 family