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D75.1 ICD-10-CM Code: Secondary polycythemia

Compare with another code for D75.1Check this code on a claim

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Official instructions
11 inclusion terms · 2 Excludes1 · 6 Excludes2

What these terms mean →

Billable · FY2027A valid, specific ICD-10-CM code, reportable for dates of service in FY2027.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too, and is marked with where it comes from.

Excludes1Not reported with this code unless documented as unrelated
  • polycythemia neonatorum (P61.1)
  • polycythemia vera (D45)
Excludes2from D75Not included here; may be reported together
  • acute lymphadenitis (L04.-)
  • chronic lymphadenitis (I88.1)
  • enlarged lymph nodes (R59.-)
  • hypergammaglobulinemia NOS (D89.2)

+2 more in Instructions

IncludesWhat this code covers
  • Acquired polycythemia
  • Emotional polycythemia
  • Erythrocytosis NOS
  • Hypoxemic polycythemia

+7 more in Instructions

Where it sits Source: CMS/NCHS

Under:Chapter 3: Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune MechanismD70-D77 Other disorders of blood and blood-forming organsD75 Other and unspecified diseases of blood and blood-forming organs

Most relevant related codes MedCoder-derived

Read off the official notes above and this code’s own position in the tabular list. Which to report is a documentation question; Compare shows the two side by side.

CompareCheck ClaimView Related Codes

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 814 — RETICULOENDOTHELIAL AND IMMUNITY DISORDERS WITH MCC (MDC 16)
  • MS-DRG 815 — RETICULOENDOTHELIAL AND IMMUNITY DISORDERS WITH CC (MDC 16)
  • MS-DRG 816 — RETICULOENDOTHELIAL AND IMMUNITY DISORDERS WITHOUT CC/MCC (MDC 16)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for D75.1 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Notes without a marker are published on D75.1 itself; “inherited from” names the category or block whose note applies here.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Acquired polycythemia
  • Emotional polycythemia
  • Erythrocytosis NOS
  • Hypoxemic polycythemia
  • Nephrogenous polycythemia
  • Polycythemia due to erythropoietin
  • Polycythemia due to fall in plasma volume
  • Polycythemia due to high altitude
  • Polycythemia due to stress
  • Polycythemia NOS
  • Relative polycythemia

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Source: inherited from D75

Coder workflow for D75.1

MedCoder structured workflow — derived from this code’s own official record

Before you code D75.1

  1. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with D75.1. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support a condition named in D75.1’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewP61.1, D45

Consider D75.1. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Official instructions as workflow

  • Excludes1 — check before selecting D75.1(2 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with D75.1: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareP61.1, D45

    See the official tabular notes · Guidelines I.A.12.a

  • Excludes2 — not part of D75.1(6 notes)

    Coding workflow: The conditions named in this note are not included in D75.1. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    CompareL04, I88.1, R59, D89.2, I88.9, I88.0

    See the official tabular notes · Guidelines I.A.12.b

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition D75.1 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewP61.1, D45

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Don’t confuse D75.1 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of D75.1 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • P61.1— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of polycythemia neonatorum moves the case to P61.1; the two are not reported together unless documented as unrelated.

    Full comparison: D75.1 vs P61.1 →

  • D45— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of polycythemia vera moves the case to D45; the two are not reported together unless documented as unrelated.

    Full comparison: D75.1 vs D45 →

  • D75.9— Specificity relationship (Review)

    Overlapping diagnoses in the same category.

    Overlapping codes in the same category — the documentation decides which is the more specific fit.

    What moves you there: A record that documents no more than “Disease of blood and blood-forming organs, unspecified” takes D75.9; specificity in the record moves it back here.

    Full comparison: D75.1 vs D75.9 →

  • L04— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of acute lymphadenitis adds L04; it is not part of this code and both may be reported when both are documented.

    Full comparison: D75.1 vs L04 →

  • I88.1— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of chronic lymphadenitis adds I88.1; it is not part of this code and both may be reported when both are documented.

    Full comparison: D75.1 vs I88.1 →

  • R59— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of enlarged lymph nodes adds R59; it is not part of this code and both may be reported when both are documented.

    Full comparison: D75.1 vs R59 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Secondary polycythemia is a billable ICD-10-CM diagnosis code (D75.1).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Official Coding Guidelines

No excerpt in the ICD-10-CM Official Guidelines names this code specifically. Its chapter carries only this chapter-wide note:

Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Reserved for future guideline expansion

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name D75.1 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 3 Excludes1 notes across 3 chapters: D45 — Polycythemia vera, D58.2 — Other hemoglobinopathies, R71 — Abnormality of red blood cells.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 1 Excludes2 note: T70.2 — Other and unspecified effects of high altitude.

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 21 Code First instructions: T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics (via D75.-), T36-T39 — Antibiotics & Anti-infectives (T36-T39) (via D75.-), T36-T50 — Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances (T36-T50) (via D75.-), T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics (via D75.-), T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified (via D75.-), T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (via D75.-), T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens] (via D75.-), T40-T41 — Analgesics & Antipyretics (T40-T41) (via D75.-), T41 — Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases (via D75.-), T42 — Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (via D75.-), T42-T43 — Anticonvulsants & Psychotropics (T42-T43) (via D75.-), T43 — Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified (via D75.-), T44 — Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system (via D75.-), T44-T46 — Cardiovascular & Gastrointestinal (T44-T46) (via D75.-), T45 — Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (via D75.-), T46 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (via D75.-), T47 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal system (via D75.-), T47-T50 — Hormones & Systemic Agents (T47-T50) (via D75.-), T48 — Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system (via D75.-), T49 — Poisoning by, adverse effect of and underdosing of topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinorlaryngological and dental drugs (via D75.-), +1 more.

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 3 MS-DRGs: DRG 814 (MDC 16), DRG 815 (MDC 16), DRG 816 (MDC 16).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):BLD010 — Other specified and unspecified hematologic conditions (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Other specified and unspecified hematologic conditions).

A18.85 — Tuberculosis of spleen, B51.0 — Plasmodium vivax malaria with rupture of spleen, D73.0 — Hyposplenism, D73.1 — Hypersplenism, D73.2 — Chronic congestive splenomegaly, D73.3 — Abscess of spleen, D73.4 — Cyst of spleen, D73.5 — Infarction of spleen, D73.89 — Other diseases of spleen, D73.9 — Disease of spleen, unspecified, D74.0 — Congenital methemoglobinemia, D74.8 — Other methemoglobinemias, D74.9 — Methemoglobinemia, unspecified, D75.0 — Familial erythrocytosis, D75.81 — Myelofibrosis, D75.89 — Other specified diseases of blood and blood-forming organs, D75.9 — Disease of blood and blood-forming organs, unspecified, D75.A — Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia, D77 — Other disorders of blood and blood-forming organs in diseases classified elsewhere, M36.3 — Arthropathy in other blood disorders

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “High”, “Stress”, “Effect, adverse”, …; these codes share that main term but sit in a different category of the Tabular List.

A93.2 — Colorado tick fever (tick fever), B56.0 — Gambiense trypanosomiasis (sleeping, Gambian), B56.1 — Rhodesiense trypanosomiasis (sleeping, Rhodesian), B56.9 — African trypanosomiasis, unspecified (sleeping), C94.0 — Acute erythroid leukemia, D45 — Polycythemia vera (vera), D50.8 — Other iron deficiency anemias (green), E78.00 — Pure hypercholesterolemia, unspecified (cholesterol), E78.1 — Pure hyperglyceridemia (triglycerides), E78.2 — Mixed hyperlipidemia (cholesterol, with high triglycerides), F43.9 — Reaction to severe stress, unspecified, J70.0 — Acute pulmonary manifestations due to radiation (radiation NOS, pneumonitis), J70.1 — Chronic and other pulmonary manifestations due to radiation (radiation NOS, fibrosis of lung), L56.8 — Other specified acute skin changes due to ultraviolet radiation (ultraviolet NOS, dermatitis or eczema, acute), L59.8 — Other specified disorders of the skin and subcutaneous tissue related to radiation (infrared NOS, dermatitis or eczema), L59.9 — Disorder of the skin and subcutaneous tissue related to radiation, unspecified (radiation NOS, skin), O29.3 — Toxic reaction to local anesthesia during pregnancy (anesthesia, local, toxic, in pregnancy NEC), O32.4 — Maternal care for high head at term (head at term), O74.4 — Toxic reaction to local anesthesia during labor and delivery (anesthesia, local, toxic, in labor and delivery), O74.5 — Spinal and epidural anesthesia-induced headache during labor and delivery (anesthesia, spinal and epidural, headache, in labor and delivery), +60 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Partial Thromboplastin Time (PTT) Test

Contextual Map

Every relationship of D75.1 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run D75.1 with these 13 related codes in Claim Check

Hierarchy

Excludes1

Referenced by Excludes1 notes

Referenced by Excludes2 notes

Referenced by Code First instructions (21)

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 16 — Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders[MDC crossing]: “Diseases and Disorders of Blood, Blood Forming Organs and Immunologic Disorders — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 1,615 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Index entries (32)

  • Disease, diseased, Gaisböck's (polycythemia hypertonica)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Effect, adverse, high altitude NEC, polycythemia[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Erythremia (acute), secondary[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Erythrocytosis (megalosplenic) (secondary)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Erythrocytosis (megalosplenic) (secondary), secondary[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Erythrocytosis (megalosplenic) (secondary), stress[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Gaisböck's disease (polycythemia hypertonica)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • High, altitude effects, polycythemia[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • and 24 more

Nearest codes (16)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Indexed Clinical Terms (32)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Coding guidelines Official source data
ICD-10-CM Official Guidelines for Coding and Reporting (FY2027), quoted by section Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "D75.1 — Secondary polycythemia." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/d75.1-secondary-polycythemia

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Secondary polycythemia

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to D75.1 in its code family, with their registry titles.

View all codes in the D75 family