D89.89 is the authoritative medical code for Other specified disorders involving the immune mechanism, not elsewhere classified. This classification is used in medical billing and clinical recording to specify the clinical criteria for other specified disorders involving the immune mechanism, not elsewhere classified (ICD-10-CM D89.89), ensuring healthcare documentation aligns with 2026 federal coding standards.
Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.
Official Registry Overview & Definition
Other specified disorders involving the immune mechanism, not elsewhere classified is a billable ICD-10-CM diagnosis code D89.89. Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus HIV disease; sarcoidosis. Excludes1 (not coded here): human immunodeficiency virus disease B20; hyperglobulinemia NOS R77.1; monoclonal gammopathy (of undetermined significance) D47.2; autoimmune disease systemic NOS M35.9; functional disorders of polymorphonuclear neutrophils D71-; human immunodeficiency virus HIV disease B20. Excludes2 (not included here): transplant failure and rejection T86.-.
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for D89.89 in the official ICD-10-CM tabular list.
Includes
Conditions the official ICD-10-CM tabular list includes under this code.
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus HIV disease
- sarcoidosis
Excludes1 — Not Coded Here
Conditions that can never be reported with this code; the two are mutually exclusive.
- human immunodeficiency virus disease B20
- hyperglobulinemia NOS R77.1
- monoclonal gammopathy (of undetermined significance) D47.2
- autoimmune disease systemic NOS M35.9
- functional disorders of polymorphonuclear neutrophils D71-
- human immunodeficiency virus HIV disease B20
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- transplant failure and rejection T86.-
Frequently Asked Questions (FAQ) & Clinical Guidance
What can't be coded together with D89.89?
Per Excludes1 instructions, D89.89 must not be reported with: human immunodeficiency virus disease (B20); hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9).
Can D89.89 be reported alongside related conditions?
Per Excludes2 instructions, D89.89 and the following may both be reported when both are present: transplant failure and rejection (T86.-).
Codes in This Family (28)
Official ICD-10-CM classifications in the same code family as D89.89, with their registry titles.
- D89 — Other disorders involving the immune mechanism, not elsewhere classified
- D89.0 — Polyclonal hypergammaglobulinemia
- D89.1 — Cryoglobulinemia
- D89.2 — Hypergammaglobulinemia, unspecified
- D89.3 — Immune reconstitution syndrome
- D89.4 — Mast cell activation syndrome and related disorders
- D89.40 — Mast cell activation, unspecified
- D89.41 — Monoclonal mast cell activation syndrome
- D89.42 — Idiopathic mast cell activation syndrome
- D89.43 — Secondary mast cell activation
- D89.44 — Hereditary alpha tryptasemia
- D89.49 — Other mast cell activation disorder
- D89.8 — Other specified disorders involving the immune mechanism, not elsewhere classified
- D89.81 — Graft-versus-host disease
- D89.810 — Acute graft-versus-host disease
- D89.811 — Chronic graft-versus-host disease
- D89.812 — Acute on chronic graft-versus-host disease
- D89.813 — Graft-versus-host disease, unspecified
- D89.82 — Autoimmune lymphoproliferative syndrome [ALPS]
- D89.83 — Cytokine release syndrome
- D89.831 — Cytokine release syndrome, grade 1
- D89.832 — Cytokine release syndrome, grade 2
- D89.833 — Cytokine release syndrome, grade 3
- D89.834 — Cytokine release syndrome, grade 4
- D89.835 — Cytokine release syndrome, grade 5
- D89.839 — Cytokine release syndrome, grade unspecified
- D89.84 — IgG4-related disease
- D89.9 — Disorder involving the immune mechanism, unspecified
Indexed Clinical Terms (6)
Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.
- Disorder (of), autoimmune
- Disorder (of), immune mechanism (immunity), specified type NEC
- PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections syndrome)
- PANS (Pediatric Acute-onset Neuropsychiatric Syndrome)
- Syndrome, pediatric acute-onset neuropsychiatric (PANS)
- Syndrome, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS)
Related Codes & Numerical Sequence (Crawl Map)
Search engines and indexers are advised to traverse adjacent medical codes in this sub-chapter range to find correlated diagnoses or therapeutic procedures: