D89.810 is the authoritative medical code for Acute graft-versus-host disease. This classification is used in medical billing and clinical recording to specify the clinical criteria for acute graft-versus-host disease (ICD-10-CM D89.810), ensuring healthcare documentation aligns with 2026 federal coding standards.
Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.
Official Registry Overview & Definition
Acute graft-versus-host disease is a billable ICD-10-CM diagnosis code D89.810. Includes: defects in the complement system; immunodeficiency disorders, except human immunodeficiency virus HIV disease; sarcoidosis. Excludes1 (not coded here): hyperglobulinemia NOS R77.1; monoclonal gammopathy (of undetermined significance) D47.2; autoimmune disease systemic NOS M35.9; functional disorders of polymorphonuclear neutrophils D71-; human immunodeficiency virus HIV disease B20. Excludes2 (not included here): transplant failure and rejection T86.-. Code first: underlying cause, such as:; complications of transplanted organs and tissue T86.-; complications of blood transfusion T80.89. Use additional code: code to identify associated manifestations, such as:; desquamative dermatitis L30.8; diarrhea R19.7; elevated bilirubin R17; hair loss L65.9.
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for D89.810 in the official ICD-10-CM tabular list.
Includes
Conditions the official ICD-10-CM tabular list includes under this code.
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus HIV disease
- sarcoidosis
Excludes1 — Not Coded Here
Conditions that can never be reported with this code; the two are mutually exclusive.
- hyperglobulinemia NOS R77.1
- monoclonal gammopathy (of undetermined significance) D47.2
- autoimmune disease systemic NOS M35.9
- functional disorders of polymorphonuclear neutrophils D71-
- human immunodeficiency virus HIV disease B20
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- transplant failure and rejection T86.-
Code First
Underlying conditions that must be sequenced before this code.
- underlying cause, such as:
- complications of transplanted organs and tissue T86.-
- complications of blood transfusion T80.89
Use Additional Code
Supplementary codes the tabular list directs you to add.
- code to identify associated manifestations, such as:
- desquamative dermatitis L30.8
- diarrhea R19.7
- elevated bilirubin R17
- hair loss L65.9
Frequently Asked Questions (FAQ) & Clinical Guidance
What can't be coded together with D89.810?
Per Excludes1 instructions, D89.810 must not be reported with: hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2); autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71-).
Can D89.810 be reported alongside related conditions?
Per Excludes2 instructions, D89.810 and the following may both be reported when both are present: transplant failure and rejection (T86.-).
Does D89.810 need to be sequenced after another code?
Yes. Code first: underlying cause, such as:; complications of transplanted organs and tissue (T86.-); complications of blood transfusion (T80.89).
Is an additional code needed with D89.810?
Use additional code(s) to specify: code to identify associated manifestations, such as:; desquamative dermatitis (L30.8); diarrhea (R19.7); elevated bilirubin (R17).
Codes in This Family (28)
Official ICD-10-CM classifications in the same code family as D89.810, with their registry titles.
- D89 — Other disorders involving the immune mechanism, not elsewhere classified
- D89.0 — Polyclonal hypergammaglobulinemia
- D89.1 — Cryoglobulinemia
- D89.2 — Hypergammaglobulinemia, unspecified
- D89.3 — Immune reconstitution syndrome
- D89.4 — Mast cell activation syndrome and related disorders
- D89.40 — Mast cell activation, unspecified
- D89.41 — Monoclonal mast cell activation syndrome
- D89.42 — Idiopathic mast cell activation syndrome
- D89.43 — Secondary mast cell activation
- D89.44 — Hereditary alpha tryptasemia
- D89.49 — Other mast cell activation disorder
- D89.8 — Other specified disorders involving the immune mechanism, not elsewhere classified
- D89.81 — Graft-versus-host disease
- D89.811 — Chronic graft-versus-host disease
- D89.812 — Acute on chronic graft-versus-host disease
- D89.813 — Graft-versus-host disease, unspecified
- D89.82 — Autoimmune lymphoproliferative syndrome [ALPS]
- D89.83 — Cytokine release syndrome
- D89.831 — Cytokine release syndrome, grade 1
- D89.832 — Cytokine release syndrome, grade 2
- D89.833 — Cytokine release syndrome, grade 3
- D89.834 — Cytokine release syndrome, grade 4
- D89.835 — Cytokine release syndrome, grade 5
- D89.839 — Cytokine release syndrome, grade unspecified
- D89.84 — IgG4-related disease
- D89.89 — Other specified disorders involving the immune mechanism, not elsewhere classified
- D89.9 — Disorder involving the immune mechanism, unspecified
Indexed Clinical Terms (3)
Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.
- Disease, diseased, graft-versus-host (GVH), acute
- Disease, diseased, host-versus-graft, acute
- Graft-versus-host disease, acute
Related Codes & Numerical Sequence (Crawl Map)
Search engines and indexers are advised to traverse adjacent medical codes in this sub-chapter range to find correlated diagnoses or therapeutic procedures: