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D89.1 ICD-10-CM Code: Cryoglobulinemia

Compare with another code for D89.1Check this code on a claim

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Official instructions
10 inclusion terms · 4 Excludes1 · 2 Excludes2
Risk adjustment
CMS-HCC V22 category 23 · RxHCC V08 category 99

What these terms mean →

Billable · FY2027A valid, specific ICD-10-CM code, reportable for dates of service in FY2027.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too, and is marked with where it comes from.

Excludes1Not reported with this code unless documented as unrelated
  • hyperglobulinemia NOS (R77.1) (from D89)
  • monoclonal gammopathy (of undetermined significance) (D47.2) (from D89)
  • autoimmune disease (systemic) NOS (M35.9) (from D80-D89)
  • functional disorders of polymorphonuclear neutrophils (D71-) (from D80-D89)
Excludes2Not included here; may be reported together
  • transplant failure and rejection (T86.-) (from D89)
  • human immunodeficiency virus [HIV] disease (B20) (from D80-D89)
IncludesWhat this code covers
  • defects in the complement system (from D80-D89)
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease (from D80-D89)
  • sarcoidosis (from D80-D89)
  • Cryoglobulinemic purpura

+6 more in Instructions

Where it sits Source: CMS/NCHS

Under:Chapter 3: Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune MechanismD80-D89 Certain disorders involving the immune mechanismD89 Other disorders involving the immune mechanism, not elsewhere classified

Most relevant related codes MedCoder-derived

Read off the official notes above and this code’s own position in the tabular list. Which to report is a documentation question; Compare shows the two side by side.

CompareCheck ClaimView Related Codes

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 820 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH MCC (MDC 17)
  • MS-DRG 821 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH CC (MDC 17)
  • MS-DRG 822 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITHOUT CC/MCC (MDC 17)
  • MS-DRG 823 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITH MCC (MDC 17)
  • MS-DRG 824 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITH CC (MDC 17)
  • MS-DRG 825 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITHOUT CC/MCC (MDC 17)
  • MS-DRG 840 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH MCC (MDC 17)
  • MS-DRG 841 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH CC (MDC 17)
  • MS-DRG 842 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITHOUT CC/MCC (MDC 17)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for D89.1 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Notes without a marker are published on D89.1 itself; “inherited from” names the category or block whose note applies here.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • defects in the complement system
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
  • sarcoidosis

Source: inherited from D80-D89

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Cryoglobulinemic purpura
  • Cryoglobulinemic vasculitis
  • Essential cryoglobulinemia
  • Idiopathic cryoglobulinemia
  • Mixed cryoglobulinemia
  • Primary cryoglobulinemia
  • Secondary cryoglobulinemia

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Coder workflow for D89.1

MedCoder structured workflow — derived from this code’s own official record

Before you code D89.1

  1. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with D89.1. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support a condition named in D89.1’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewR77.1, D47.2, M35.9, D71

Consider D89.1. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Official instructions as workflow

  • Excludes1 — check before selecting D89.1(4 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with D89.1: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareR77.1, D47.2, M35.9, D71

    See the official tabular notes · Guidelines I.A.12.a

  • Excludes2 — not part of D89.1(2 notes)

    Coding workflow: The conditions named in this note are not included in D89.1. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    CompareT86, B20

    See the official tabular notes · Guidelines I.A.12.b

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition D89.1 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewR77.1, D47.2, M35.9, D71

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Don’t confuse D89.1 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of D89.1 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • R77.1— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of hyperglobulinemia NOS moves the case to R77.1; the two are not reported together unless documented as unrelated.

    Full comparison: D89.1 vs R77.1 →

  • D47.2— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of monoclonal gammopathy (of undetermined significance) moves the case to D47.2; the two are not reported together unless documented as unrelated.

    Full comparison: D89.1 vs D47.2 →

  • M35.9— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of autoimmune disease (systemic) NOS moves the case to M35.9; the two are not reported together unless documented as unrelated.

    Full comparison: D89.1 vs M35.9 →

  • D71— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of functional disorders of polymorphonuclear neutrophils moves the case to D71; the two are not reported together unless documented as unrelated.

    Full comparison: D89.1 vs D71 →

  • D89.2— Specificity relationship (Review)

    Overlapping diagnoses in the same category.

    Overlapping codes in the same category — the documentation decides which is the more specific fit.

    What moves you there: A record that documents no more than “Hypergammaglobulinemia, unspecified” takes D89.2; specificity in the record moves it back here.

    Full comparison: D89.1 vs D89.2 →

  • T86— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of transplant failure and rejection adds T86; it is not part of this code and both may be reported when both are documented.

    Full comparison: D89.1 vs T86 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Cryoglobulinemia is a billable ICD-10-CM diagnosis code (D89.1).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Official Coding Guidelines

No excerpt in the ICD-10-CM Official Guidelines names this code specifically. Its chapter carries only this chapter-wide note:

Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Reserved for future guideline expansion

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name D89.1 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 2 Excludes1 notes: D69 — Purpura and other hemorrhagic conditions, D72 — Other disorders of white blood cells (via D89.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 3 Code First instructions across 2 chapters: J99 — Respiratory disorders in diseases classified elsewhere, N08 — Glomerular disorders in diseases classified elsewhere, N16 — Renal tubulo-interstitial disorders in diseases classified elsewhere.

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 9 MS-DRGs: DRG 820 (MDC 17), DRG 821 (MDC 17), DRG 822 (MDC 17), DRG 823 (MDC 17), DRG 824 (MDC 17), DRG 825 (MDC 17), DRG 840 (MDC 17), DRG 841 (MDC 17), DRG 842 (MDC 17).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):BLD008 — Immunity disorders (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Immunity disorders).

D86.81 — Sarcoid meningitis, D86.82 — Multiple cranial nerve palsies in sarcoidosis, D86.83 — Sarcoid iridocyclitis, D86.84 — Sarcoid pyelonephritis, D86.85 — Sarcoid myocarditis, D86.86 — Sarcoid arthropathy, D86.87 — Sarcoid myositis, D86.89 — Sarcoidosis of other sites, D86.9 — Sarcoidosis, unspecified, D89.0 — Polyclonal hypergammaglobulinemia, D89.2 — Hypergammaglobulinemia, unspecified, D89.3 — Immune reconstitution syndrome, D89.40 — Mast cell activation, unspecified, D89.41 — Monoclonal mast cell activation syndrome, D89.42 — Idiopathic mast cell activation syndrome, D89.43 — Secondary mast cell activation, D89.44 — Hereditary alpha tryptasemia, D89.49 — Other mast cell activation disorder, D89.810 — Acute graft-versus-host disease, D89.811 — Chronic graft-versus-host disease, +64 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Purpura”, “Pyelonephritis”, “Nephritis, nephritic”, …; these codes share that main term but sit in a different category of the Tabular List.

C95.9 — Leukemia, unspecified (in, leukemia NEC), D65 — Disseminated intravascular coagulation [defibrination syndrome] (gangrenous), D69.0 — Allergic purpura (toxic), D69.2 — Other nonthrombocytopenic purpura, D69.3 — Immune thrombocytopenic purpura (idiopathic), D69.42 — Congenital and hereditary thrombocytopenia purpura (thrombocytopenic, hereditary), D69.49 — Other primary thrombocytopenia (primary), D69.51 — Posttransfusion purpura (posttransfusion), D69.8 — Other specified hemorrhagic conditions (capillary fragility), D86.84 — Sarcoid pyelonephritis (in, sarcoidosis), E54 — Ascorbic acid deficiency (scorbutic), E72.04 — Cystinosis (in, cystinosis), E74.00 — Glycogen storage disease, unspecified (tubulo-interstitial, due to, glycogen storage disease), E74.09 — Other glycogen storage disease (in, glycogen storage disease), E75.21 — Fabry (-Anderson) disease (in, Fabrydisease), E78.6 — Lipoprotein deficiency (in, lecithin cholesterol acyltransferase deficiency), E83.01 — Wilson's disease (in, Wilson's disease), E85.4 — Organ-limited amyloidosis (amyloid), H35.06 — Retinal vasculitis (retina), I33.0 — Acute and subacute infective endocarditis (in, subacute bacterial endocarditis), +100 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Partial Thromboplastin Time (PTT) Test, Prothrombin Time Test and INR (PT/INR)

Contextual Map

Every relationship of D89.1 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run D89.1 with these 5 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Code First instructions

Clinical classification (CCSR)

MS-DRG Grouper (9)

MDC crossing

  • MDC 17 — Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms[MDC crossing]: “Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 4,735 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Index entries (9)

  • Cryoglobulinemia (essential) (idiopathic) (mixed) (primary) (purpura) (secondary) (vasculitis)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Cryoglobulinemia (essential) (idiopathic) (mixed) (primary) (purpura) (secondary) (vasculitis), with lung involvement[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Disorder (of), glomerular (in), cryoglobulinemia[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Disorder (of), tubulo-interstitial (in), mixed cryoglobulinemia[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Glomerulonephritis, in (due to), cryoglobulinemia[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic), tubulo-interstitial (in), due to, cryoglobulinemia[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Purpura, cryoglobulinemic[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Pyelonephritis, in (due to), cryoglobulinemia (mixed)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • and 1 more

Nearest codes (28)

Change history (3)

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Indexed Clinical Terms (9)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Coding guidelines Official source data
ICD-10-CM Official Guidelines for Coding and Reporting (FY2027), quoted by section Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "D89.1 — Cryoglobulinemia." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/d89.1-cryoglobulinemia

Change history

Changed in FY2027, the release in force: Excludes2 note added; Excludes1 note removed.

  • FY2027 — October 1, 2026
    Excludes2 note added
    human immunodeficiency virus [HIV] disease (B20)
    FY2027 changes
  • FY2027 — October 1, 2026
    Excludes1 note removed
    human immunodeficiency virus [HIV] disease (B20)
    FY2027 changes
  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Cryoglobulinemia

Nearest Codes in This Family

Official ICD-10-CM classifications closest to D89.1 in its code family, with their registry titles.

View all codes in the D89 family