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E08.43 ICD-10-CM Code: Diabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathy

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
1 inclusion term · 8 Excludes1 · 5 use-additional codes · 7 code-first instructions
Risk adjustment
CMS-HCC V28: 1 category · CMS-HCC V22 category 18 · RxHCC V08 category 30

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

  • MS-DRG 008 — SIMULTANEOUS PANCREAS AND KIDNEY TRANSPLANT (MDC PRE)
  • MS-DRG 010 — PANCREAS TRANSPLANT (MDC PRE)
  • MS-DRG 019 — SIMULTANEOUS PANCREAS AND KIDNEY TRANSPLANT WITH HEMODIALYSIS (MDC PRE)
  • MS-DRG 073 — CRANIAL AND PERIPHERAL NERVE DISORDERS WITH MCC (MDC 01)
  • MS-DRG 074 — CRANIAL AND PERIPHERAL NERVE DISORDERS WITHOUT MCC (MDC 01)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

  • HCC 37 — Diabetes with Chronic Complications (supersedes HCC 38)

Other models: CMS-HCC V22 HCC 18 · RxHCC V08 HCC 30

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for E08.43 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on E08.43 itself; “inherited from” names the category or block whose note applies here.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Diabetes mellitus due to underlying condition with diabetic gastroparesis

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Source: inherited from E08

Code First

Underlying conditions that must be sequenced before this code.

  • the underlying condition, such as:
  • congenital rubella (P35.0)
  • Cushing's syndrome (E24.-)
  • cystic fibrosis (E84.-)
  • malignant neoplasm (C00-C96)
  • malnutrition (E40-E46)
  • pancreatitis and other diseases of the pancreas (K85-K86.-)

Source: inherited from E08

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code to identify control using:
  • injectable non-insulin antidiabetic drugs (Z79.85)
  • insulin (Z79.4)
  • oral antidiabetic drugs (Z79.84)
  • oral hypoglycemic drugs (Z79.84)

Source: inherited from E08

Coder workflow for E08.43

MedCoder structured workflow — derived from this code’s own official record

Before you code E08.43

  1. E08.43’s title joins a condition with an associated condition or complication. Confirm each component is documented. Where the classification presumes the link through the “with” convention, only a provider statement that the conditions are unrelated defeats it. A combination code is assigned only when it fully identifies the documented conditions; a required second code for the stage, type or manifestation is still reported when the notes ask for it (Guidelines I.B.9, I.A.15).

    Guide: Combination codes →

  2. Confirm the documented diabetes type or cause (the E08–E13 categories are separated by it) and every documented complication or manifestation; the code is built from the type first and the complication second. Then work the category’s Use Additional Code notes for medication and control status. Type 2 is the default only when the type is not documented, and insulin or other medication use does not by itself establish the type (Guidelines I.C.4.a.2, I.C.4.a.3).

    Guide: Secondary diabetes (E08, E09, E13) →

  3. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with E08.43. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support a condition named in E08.43’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewE09, O24.4, P70.2, E13, E10, E11

  2. Is the underlying (etiologic) condition the Code First note names documented?
    Yes → Sequence the underlying condition first, then E08.43.
    No → Continue; do not add an underlying condition the record does not document.

    ReviewP35.0, E24, E84

Consider E08.43. Then work the Use Additional Code note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
The associated condition or complication
Whether the associated condition the title names is documented; the “with” convention presumes some links, and a provider statement that the conditions are unrelated defeats it (Guidelines I.A.15).
The underlying (etiologic) condition
Named in the Code First note; sequenced before this code when documented (Guidelines I.A.13).
The conditions the Use Additional Code note names
Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.
Diabetes type or cause, each complication, and medication use
The type is documented, not inferred from medication (Guidelines I.C.4.a.3); each documented complication takes its own combination code.

Official instructions as workflow

  • Excludes1 — check before selecting E08.43(8 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with E08.43: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareE09, O24.4, P70.2, E13, E10, E11

    See the official tabular notes · Guidelines I.A.12.a

  • Code First — sequencing check(7 notes)

    Coding workflow: Check whether the underlying or etiologic condition the note names is documented. When it is, sequence it before E08.43. Do not add an underlying condition the record does not document.

    ReviewP35.0, E24, E84

    See the official tabular notes · Guidelines I.A.13

  • Use Additional Code — after identifying E08.43(5 notes)

    Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with E08.43 when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.

    ReviewZ79.85, Z79.4, Z79.84

    See the official tabular notes · Guidelines I.A.13

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition E08.43 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewE09, O24.4, P70.2, E13, E10, E11

Documentation: Only one of the components this code’s title joins is documented.

Coding question: Is E08.43 supported?

Path: Review the code for the documented component on its own.

Reason: A combination code is assigned only when it fully identifies the documented conditions; otherwise the documented component takes its own code (Guidelines I.B.9).

Documentation: The underlying condition the Code First note names is documented alongside this condition.

Coding question: How are the two sequenced?

Path: Review the Code First note.

Reason: The underlying condition is sequenced first and the manifestation follows (Guidelines I.A.13).

ReviewP35.0, E24, E84

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Diabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathy is a billable ICD-10-CM diagnosis code (E08.43).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (3)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Official Coding Guidelines

Official source data — quoted verbatim from the CMS/NCHS Official Guidelines

Official source data — quoted verbatim from the CMS/NCHS Official Guidelines

Verbatim excerpts from the ICD-10-CM Official Guidelines for Coding and Reporting (CMS/NCHS) that govern this code.

Chapter 4: Endocrine, Nutritional, and Metabolic Diseases (E00 -E89)

a. Diabetes mellitus The diabetes mellitus codes are combination codes that include the type of diabetes mellitus, the body system affected, and the complications affecting that body system. As many codes within a particular category as are necessary to describe all of the complications of the disease may be used. They should be sequenced based on the reason for a particular encounter. Assign as many codes from categories E08 – E13 as needed to identify all of the associated conditions that the patient has.

Chapter 4: Endocrine, Nutritional, and Metabolic Diseases (E00 -E89)

6) Secondary diabetes mellitus Codes under categories E08, Diabetes mellitus due to underlying condition, E09, Drug or chemical induced diabetes mellitus, and E13, Other specified diabetes mellitus, identify complications/manifestations associated with secondary diabetes mellitus. Secondary diabetes is always caused by another condition or event (e.g., cystic fibrosis, malignant neoplasm of pancreas, pancreatectomy, adverse effect of drug, or poisoning).

Chapter 4: Endocrine, Nutritional, and Metabolic Diseases (E00 -E89)

(b) Assigning and sequencing secondary diabetes codes and its causes The sequencing of the secondary diabetes codes in relationship to codes for the cause of the diabetes is based on the Tabular List instructions for categories E08, E09 and E13.

Chapter 15: Pregnancy, Childbirth, and the Puerperium (O00-O9A)

g. Diabetes mellitus in pregnancy Diabetes mellitus is a significant complicating factor in pregnancy. Pregnant patients who are diabetic should be assigned a code from category O24, Diabetes mellitus in pregnancy, childbirth, and the puerperium, first, followed by the appropriate diabetes code(s) (E08-E13) from Chapter 4.

Decision Points

The directives on this code's own record, as a pre-claim checklist.

  1. Sequencing: 7 Code First instructions — the underlying condition is sequenced before this code when present. See the Code First notes
  2. 5 Use Additional Code instructions — report the named additional code(s) when the documentation supports them. See the Use Additional Code notes
  3. 8 Excludes1 entries — codes named there are generally not reported together with this code (Guidelines I.A.12.a). See the Excludes1 notes

Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.

Verify Before Coding

  • Principal-diagnosis restriction. This is a manifestation code: the Medicare Code Editor requires the underlying condition (etiology) to be sequenced first, with this code reported after it.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name E08.43 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 23 Excludes1 notes across 8 chapters: E09 — Drug or chemical induced diabetes mellitus (via E08.-), E10 — Type 1 diabetes mellitus (via E08.-), E11 — Type 2 diabetes mellitus (via E08.-), E13 — Other specified diabetes mellitus (via E08.-), E74 — Other disorders of carbohydrate metabolism (via E08.-), E87.2 — Acidosis (via E08.-), G54.5 — Neuralgic amyotrophy (via E08.-), G59 — Mononeuropathy in diseases classified elsewhere (via E08.-), G63 — Polyneuropathy in diseases classified elsewhere (via E08.-), G99.0 — Autonomic neuropathy in diseases classified elsewhere (via E08.-), H20.0 — Acute and subacute iridocyclitis (via E08.-), I73.8 — Other specified peripheral vascular diseases (via E08.-), I79.8 — Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere (via E08.-), L92.1 — Necrobiosis lipoidica, not elsewhere classified (via E08.-), L99 — Other disorders of skin and subcutaneous tissue in diseases classified elsewhere (via E08.-), M14 — Arthropathies in other diseases classified elsewhere (via E08.-), M14.6 — Charcôt's joint (via E08.-), M90 — Osteopathies in diseases classified elsewhere (via E08.-), N08 — Glomerular disorders in diseases classified elsewhere (via E08.-), N16 — Renal tubulo-interstitial disorders in diseases classified elsewhere (via E08.-), +3 more.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 4 Excludes2 notes across 4 chapters: H35 — Other retinal disorders (via E08.-), I96 — Gangrene, not elsewhere classified (via E08.-), K31 — Other diseases of stomach and duodenum, R11.15 — Cyclical vomiting syndrome unrelated to migraine (via E08.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 2 Code First instructions across 2 chapters: D84.81 — Immunodeficiency due to conditions classified elsewhere (via E08.-), K31.84 — Gastroparesis.

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

Referenced by 1 Code Also instruction: N76.82 — Fournier disease of vagina and vulva (via E08.-).

These codes suggest coding this condition alongside when both are present.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 5 MS-DRGs: DRG 008 (MDC PRE), DRG 010 (MDC PRE), DRG 019 (MDC PRE), DRG 073 (MDC 01), DRG 074 (MDC 01).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):END003 — Diabetes mellitus with complication; END006 — Diabetes mellitus, due to underlying condition, drug or chemical induced, or other specified type; NVS015 — Polyneuropathies.

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Principal diagnosis restriction (Medicare Code Editor)

Manifestation code — the underlying condition is sequenced first.

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Diabetes with Chronic Complications) for risk-adjusted payment.

E08.3599 — Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy without macular edema, unspecified eye, E08.36 — Diabetes mellitus due to underlying condition with diabetic cataract, E08.37X1 — Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatment, right eye, E08.37X2 — Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatment, left eye, E08.37X3 — Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatment, bilateral, E08.37X9 — Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatment, unspecified eye, E08.39 — Diabetes mellitus due to underlying condition with other diabetic ophthalmic complication, E08.40 — Diabetes mellitus due to underlying condition with diabetic neuropathy, unspecified, E08.41 — Diabetes mellitus due to underlying condition with diabetic mononeuropathy, E08.42 — Diabetes mellitus due to underlying condition with diabetic polyneuropathy, E08.44 — Diabetes mellitus due to underlying condition with diabetic amyotrophy, E08.49 — Diabetes mellitus due to underlying condition with other diabetic neurological complication, E08.51 — Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy without gangrene, E08.52 — Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene, E08.59 — Diabetes mellitus due to underlying condition with other circulatory complications, E08.610 — Diabetes mellitus due to underlying condition with diabetic neuropathic arthropathy, E08.618 — Diabetes mellitus due to underlying condition with other diabetic arthropathy, E08.620 — Diabetes mellitus due to underlying condition with diabetic dermatitis, E08.621 — Diabetes mellitus due to underlying condition with foot ulcer, E08.622 — Diabetes mellitus due to underlying condition with other skin ulcer, +287 more

Related risk categories

These categories interact through CMS's HCC hierarchy — one can suppress the other's risk-adjustment weight when both are present on a claim.

Pancreas Transplant Status, Diabetes with Severe Acute Complications, Diabetes with Glycemic, Unspecified, or No Complications

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical categories (Diabetes mellitus with complication, Diabetes mellitus, due to underlying condition, drug or chemical induced, or other specified type, Polyneuropathies).

E08.3599 — Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy without macular edema, unspecified eye, E08.36 — Diabetes mellitus due to underlying condition with diabetic cataract, E08.37X1 — Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatment, right eye, E08.37X2 — Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatment, left eye, E08.37X3 — Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatment, bilateral, E08.37X9 — Diabetes mellitus due to underlying condition with diabetic macular edema, resolved following treatment, unspecified eye, E08.39 — Diabetes mellitus due to underlying condition with other diabetic ophthalmic complication, E08.40 — Diabetes mellitus due to underlying condition with diabetic neuropathy, unspecified, E08.41 — Diabetes mellitus due to underlying condition with diabetic mononeuropathy, E08.42 — Diabetes mellitus due to underlying condition with diabetic polyneuropathy, E08.44 — Diabetes mellitus due to underlying condition with diabetic amyotrophy, E08.49 — Diabetes mellitus due to underlying condition with other diabetic neurological complication, E08.51 — Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy without gangrene, E08.52 — Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene, E08.59 — Diabetes mellitus due to underlying condition with other circulatory complications, E08.610 — Diabetes mellitus due to underlying condition with diabetic neuropathic arthropathy, E08.618 — Diabetes mellitus due to underlying condition with other diabetic arthropathy, E08.620 — Diabetes mellitus due to underlying condition with diabetic dermatitis, E08.621 — Diabetes mellitus due to underlying condition with foot ulcer, E08.622 — Diabetes mellitus due to underlying condition with other skin ulcer, +498 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Diabetes, diabetic”; these codes share that main term but sit in a different category of the Tabular List.

E09.00 — Drug or chemical induced diabetes mellitus with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC) (due to drug or chemical, with, hyperosmolarity), E09.01 — Drug or chemical induced diabetes mellitus with hyperosmolarity with coma (due to drug or chemical, with, hyperosmolarity, with coma), E09.10 — Drug or chemical induced diabetes mellitus with ketoacidosis without coma (due to drug or chemical, with, ketoacidosis), E09.11 — Drug or chemical induced diabetes mellitus with ketoacidosis with coma (due to drug or chemical, with, ketoacidosis, with coma), E09.21 — Drug or chemical induced diabetes mellitus with diabetic nephropathy (due to drug or chemical, with, nephropathy), E09.22 — Drug or chemical induced diabetes mellitus with diabetic chronic kidney disease (due to drug or chemical, with, chronic kidney disease), E09.29 — Drug or chemical induced diabetes mellitus with other diabetic kidney complication (due to drug or chemical, with, renal complication NEC), E09.311 — Drug or chemical induced diabetes mellitus with unspecified diabetic retinopathy with macular edema (due to drug or chemical, with, retinopathy, with macular edema), E09.319 — Drug or chemical induced diabetes mellitus with unspecified diabetic retinopathy without macular edema (due to drug or chemical, with, retinopathy), E09.321 — Drug or chemical induced diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema (due to drug or chemical, with, retinopathy, nonproliferative, with macular edema), E09.329 — Drug or chemical induced diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema (due to drug or chemical, with, retinopathy, nonproliferative), E09.331 — Drug or chemical induced diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema (due to drug or chemical, with, retinopathy, nonproliferative, moderate, with macular edema), E09.339 — Drug or chemical induced diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema (due to drug or chemical, with, retinopathy, nonproliferative, moderate), E09.341 — Drug or chemical induced diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema (due to drug or chemical, with, retinopathy, nonproliferative, severe, with macular edema), E09.349 — Drug or chemical induced diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema (due to drug or chemical, with, retinopathy, nonproliferative, severe), E09.351 — Drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy with macular edema (due to drug or chemical, with, retinopathy, proliferative, with, macular edema), E09.352 — Drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula (due to drug or chemical, with, retinopathy, proliferative, with, traction retinal detachment involving the macula), E09.353 — Drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment not involving the macula (due to drug or chemical, with, retinopathy, proliferative, with, traction retinal detachment not involving the macula), E09.354 — Drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment (due to drug or chemical, with, retinopathy, proliferative, with, combined traction retinal detachment and rhegmatogenous retinal detachment), E09.355 — Drug or chemical induced diabetes mellitus with stable proliferative diabetic retinopathy (due to drug or chemical, with, retinopathy, proliferative, with, stable proliferative diabetic retinopathy), +192 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

HbA1c Test (Glycated Hemoglobin), Blood Glucose Test, Iron Panel, Lipid Panel, Thyroid Stimulating Hormone (TSH)

Contextual Map

Every relationship of E08.43 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run E08.43 with these 15 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes (23)

Referenced by Excludes2 notes

Referenced by Code First instructions

Referenced by Code Also instructions

Clinical classification (CCSR)

Risk adjustment (CMS-HCC)

  • HCC 37 — Diabetes with Chronic Complications [CMS-HCC]: “Diabetes with Chronic Complications — supersedes HCC 38 (Diabetes with Glycemic, Unspecified, or No Complications)”— CMS-HCC V28 · 2026

MS-DRG Grouper

MDC crossing

  • Pre-MDC[MDC crossing]: “Pre-MDC — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 153 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026
  • MDC 01 — Diseases and Disorders of the Nervous System[MDC crossing]: “Diseases and Disorders of the Nervous System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 8,892 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

  • Diabetes, diabetic (mellitus) (sugar), due to underlying condition, with, autonomicneuropathy (poly)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Diabetes, diabetic (mellitus) (sugar), due to underlying condition, with, gastroparalysis[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Diabetes, diabetic (mellitus) (sugar), due to underlying condition, with, gastroparesis[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (40)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Common coding questions

Does E08.43 cover diabetic gastroparesis?

Yes — “Diabetes mellitus due to underlying condition with diabetic gastroparesis” is an inclusion term under E08.43 (autonomic polyneuropathy), which is where documented diabetic gastroparesis is coded in this family.

Can E08.43 be a principal diagnosis?

No — it is manifestation-coded and on the MCE edit-06 list; category E08’s Code First note sequences the underlying condition ahead of it. Why a manifestation code never leads the claim covers the rule.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Coding guidelines Official source data
ICD-10-CM Official Guidelines for Coding and Reporting (FY2026), quoted by section Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Risk adjustment Official source data
2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "E08.43 — Diabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathy." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/e08.43-diabetes-mellitus-due-to-underlying-condition-with-diabetic-autonomic-polyneuropathy

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Diabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathy

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to E08.43 in its code family, with their registry titles.

View all codes in the E08 family