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F48.1 ICD-10-CM Code: Depersonalization-derealization syndrome

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Risk adjustment
CMS-HCC V28: 1 category · RxHCC V08 category 133

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 882 — NEUROSES EXCEPT DEPRESSIVE (MDC 19)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

  • HCC 153 — Personality Disorders; Anorexia/Bulimia Nervosa (supersedes HCC 154, HCC 155)

Other models: RxHCC V08 HCC 133

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Don’t confuse F48.1 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of F48.1 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • F48.9— Specificity relationship (Review)

    Overlapping diagnoses in the same category.

    Overlapping codes in the same category — the documentation decides which is the more specific fit.

    What moves you there: A record that documents no more than “Nonpsychotic mental disorder, unspecified” takes F48.9; specificity in the record moves it back here.

    Full comparison: F48.1 vs F48.9 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Code Overview

Depersonalization-derealization syndrome is a billable ICD-10-CM diagnosis code (F48.1).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (10)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name F48.1 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 1 Excludes2 note: F93.0 — Separation anxiety disorder of childhood (via F48.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 1 MS-DRG: DRG 882 (MDC 19).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):MBD007 — Trauma- and stressor-related disorders (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Personality Disorders; Anorexia/Bulimia Nervosa) for risk-adjusted payment.

F21 — Schizotypal disorder, F44.0 — Dissociative amnesia, F44.1 — Dissociative fugue, F44.81 — Dissociative identity disorder, F50.00 — Anorexia nervosa, unspecified, F50.010 — Anorexia nervosa, restricting type, mild, F50.011 — Anorexia nervosa, restricting type, moderate, F50.012 — Anorexia nervosa, restricting type, severe, F50.013 — Anorexia nervosa, restricting type, extreme, F50.014 — Anorexia nervosa, restricting type, in remission, F50.019 — Anorexia nervosa, restricting type, unspecified, F50.020 — Anorexia nervosa, binge eating/purging type, mild, F50.021 — Anorexia nervosa, binge eating/purging type, moderate, F50.022 — Anorexia nervosa, binge eating/purging type, severe, F50.023 — Anorexia nervosa, binge eating/purging type, extreme, F50.024 — Anorexia nervosa, binge eating/purging type, in remission, F50.029 — Anorexia nervosa, binge eating/purging type, unspecified, F50.20 — Bulimia nervosa, unspecified, F50.21 — Bulimia nervosa, mild, F50.22 — Bulimia nervosa, moderate, +14 more

Related risk categories

These categories interact through CMS's HCC hierarchy — one can suppress the other's risk-adjustment weight when both are present on a claim.

Schizophrenia, Psychosis, Except Schizophrenia, Bipolar Disorders without Psychosis, Major Depression, Moderate or Severe, without Psychosis

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Trauma- and stressor-related disorders).

F43.23 — Adjustment disorder with mixed anxiety and depressed mood, F43.24 — Adjustment disorder with disturbance of conduct, F43.25 — Adjustment disorder with mixed disturbance of emotions and conduct, F43.29 — Adjustment disorder with other symptoms, F43.8 — Other reactions to severe stress, F43.81 — Prolonged grief disorder, F43.89 — Other reactions to severe stress, F43.9 — Reaction to severe stress, unspecified, F44.0 — Dissociative amnesia, F44.1 — Dissociative fugue, F44.2 — Dissociative stupor, F44.4 — Conversion disorder with motor symptom or deficit, F44.5 — Conversion disorder with seizures or convulsions, F44.6 — Conversion disorder with sensory symptom or deficit, F44.7 — Conversion disorder with mixed symptom presentation, F44.81 — Dissociative identity disorder, F44.89 — Other dissociative and conversion disorders, F44.9 — Dissociative and conversion disorder, unspecified, F94.1 — Reactive attachment disorder of childhood, F94.2 — Disinhibited attachment disorder of childhood, +7 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “State”, “Reaction”, “Psychoneurosis, psychoneurotic”, …; these codes share that main term but sit in a different category of the Tabular List.

F43.11 — Post-traumatic stress disorder, acute (traumatic, acute), F43.12 — Post-traumatic stress disorder, chronic (traumatic, chronic), F43.89 — Other reactions to severe stress (stress, specified NEC), F43.9 — Reaction to severe stress, unspecified (stress), F44.4 — Conversion disorder with motor symptom or deficit (larynx, hysterical), F44.89 — Other dissociative and conversion disorders (confusional), F44.9 — Dissociative and conversion disorder, unspecified (dissociative), F45.20 — Hypochondriacal disorder, unspecified (hypochondriacal), F45.21 — Hypochondriasis (hypochondriacal), F45.8 — Other somatoform disorders (colon), F60.2 — Antisocial personality disorder (psychopathic), F60.7 — Dependent personality disorder (passive dependency), F60.89 — Other specific personality disorders (personality NEC), F60.9 — Personality disorder, unspecified (character), F65.9 — Paraphilia, unspecified (sexual), F68.10 — Factitious disorder imposed on self, unspecified (compensation), F93.8 — Other childhood emotional disorders (fear, child), F94.0 — Selective mutism (adjustment, with, mutism, elective), F99 — Mental disorder, not otherwise specified (psychogenic), G83.5 — Locked-in state (locked-in), +85 more

Contextual Map

Every relationship of F48.1 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run F48.1 with this related code in Claim Check

Hierarchy

Referenced by Excludes2 notes

Clinical classification (CCSR)

Risk adjustment (CMS-HCC)

  • HCC 153 — Personality Disorders; Anorexia/Bulimia Nervosa [CMS-HCC]: “Personality Disorders; Anorexia/Bulimia Nervosa — supersedes HCC 154 (Bipolar Disorders without Psychosis), HCC 155 (Major Depression, Moderate or Severe, without Psychosis)”— CMS-HCC V28 · 2026

MS-DRG Grouper

MDC crossing

  • MDC 19 — Mental Diseases and Disorders[MDC crossing]: “Mental Diseases and Disorders — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”— CMS MS-DRG Definitions Manual · FY2027

Index entries (10)

  • Depersonalization (in neurotic state) (neurotic) (syndrome)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Derealization (neurotic)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Disorder (of), depersonalization[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Episode, depersonalization (in neurotic state)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Neurosis, neurotic, depersonalization[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Neurosis, neurotic, state, with depersonalization episode[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Psychoneurosis, psychoneurotic, depersonalization[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Reaction, psychoneurotic, depersonalization[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • and 2 more

Nearest codes

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Risk adjustment Official source data
2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "F48.1 — Depersonalization-derealization syndrome." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/f48.1-depersonalization-derealization-syndrome

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Depersonalization-derealization syndrome

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to F48.1 in its code family, with their registry titles.

View all codes in the F48 family