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I25.10 ICD-10-CM Code: Atherosclerotic heart disease of native coronary artery without angina pectoris

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
1 inclusion term · 3 Excludes2 · 10 use-additional codes · 1 code-also instruction
Risk adjustment
RxHCC V08 category 188

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for I25.10 in the official ICD-10-CM tabular list, quoted as published.

Notes without a marker are published on I25.10 itself; “inherited from” names the category or block whose note applies here.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Atherosclerotic heart disease NOS

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Code Also

Additional codes that may be required to fully describe the encounter.

  • the presence of hypertension (I10-I1A)

Source: inherited from I20-I25

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code, if applicable, to identify:
  • coronary atherosclerosis due to calcified coronary lesion (I25.84) inherited from I25.1
  • coronary atherosclerosis due to lipid rich plaque (I25.83) inherited from I25.1
  • Use additional code to identify:
  • chronic total occlusion of coronary artery (I25.82) inherited from I25
  • exposure to environmental tobacco smoke (Z77.22) inherited from I25
  • history of tobacco dependence (Z87.891) inherited from I25
  • occupational exposure to environmental tobacco smoke (Z57.31) inherited from I25
  • tobacco dependence (F17.-) inherited from I25
  • tobacco use (Z72.0) inherited from I25

Code Overview

Atherosclerotic heart disease of native coronary artery without angina pectoris is a billable ICD-10-CM diagnosis code (I25.10).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (7)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Decision Points

The directives on this code's own record, as a pre-claim checklist.

  1. 10 Use Additional Code instructions — report the named additional code(s) when the documentation supports them. See the Use Additional Code notes
  2. 1 Code Also note — a second code may apply; the guidelines leave its sequencing to the circumstances of the encounter. See the Code Also notes
  3. 3 Excludes2 entries — those conditions are not part of this code and may be reported additionally when documented. See the Excludes2 notes

Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.

Verify Before Coding

  • Age-restricted: the Medicare Code Editor lists this as an adult (age 15-124) diagnosis; other ages are presumed incorrect.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

Other codes that name I25.10 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 2 Excludes1 notes: I20 — Angina pectoris (via I25.1.-), I24.0 — Acute coronary thrombosis not resulting in myocardial infarction (via I25.1.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 5 Excludes2 notes: I25.5 — Ischemic cardiomyopathy (via I25.1.-), I25.81 — Atherosclerosis of other coronary vessels without angina pectoris, I70 — Atherosclerosis (via I25.1.-), I74 — Arterial embolism and thrombosis (via I25.-), I82 — Other venous embolism and thrombosis (via I25.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 3 Code First instructions: I25.82 — Chronic total occlusion of coronary artery (via I25.1.-), I25.83 — Coronary atherosclerosis due to lipid rich plaque (via I25.1.-), I25.84 — Coronary atherosclerosis due to calcified coronary lesion (via I25.1.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2026)

Not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity.

Potential MS-DRG participation — not a DRG assignment.

Named in the grouper logic of 2 MS-DRGs: DRG 302 (MDC 05), DRG 303 (MDC 05).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):CIR011 — Coronary atherosclerosis and other heart disease (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Coronary atherosclerosis and other heart disease).

I20.2 — Refractory angina pectoris, I20.8 — Other forms of angina pectoris, I20.81 — Angina pectoris with coronary microvascular dysfunction, I20.89 — Other forms of angina pectoris, I20.9 — Angina pectoris, unspecified, I24.0 — Acute coronary thrombosis not resulting in myocardial infarction, I24.8 — Other forms of acute ischemic heart disease, I24.81 — Acute coronary microvascular dysfunction, I24.89 — Other forms of acute ischemic heart disease, I24.9 — Acute ischemic heart disease, unspecified, I25.110 — Atherosclerotic heart disease of native coronary artery with unstable angina pectoris, I25.111 — Atherosclerotic heart disease of native coronary artery with angina pectoris with documented spasm, I25.112 — Atherosclerotic heart disease of native coronary artery with refractory angina pectoris, I25.118 — Atherosclerotic heart disease of native coronary artery with other forms of angina pectoris, I25.119 — Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris, I25.2 — Old myocardial infarction, I25.5 — Ischemic cardiomyopathy, I25.6 — Silent myocardial ischemia, I25.700 — Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris, I25.701 — Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris with documented spasm, +47 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Sclerosis, sclerotic”, “Atheroma, atheromatous”, “Arteriosclerosis, arteriosclerotic”; these codes share that main term but sit in a different category of the Tabular List.

G37.0 — Diffuse sclerosis of central nervous system (diffuse), G37.5 — Concentric sclerosis [Balo] of central nervous system (concentric), G37.9 — Demyelinating disease of central nervous system, unspecified (brain), G61.0 — Guillain-Barre syndrome (spinal, ascending), G93.81 — Temporal sclerosis (temporal), G95.19 — Other vascular myelopathies (spinal), G95.89 — Other specified diseases of spinal cord (spinal), H35.00 — Unspecified background retinopathy (retina), I05.8 — Other rheumatic mitral valve diseases (mitral), I07.8 — Other rheumatic tricuspid valve diseases (tricuspid), I27.0 — Primary pulmonary hypertension (pulmonary, artery), I34.89 — Other nonrheumatic mitral valve disorders (mitral), I35.8 — Other nonrheumatic aortic valve disorders (aorta, aortic, valve), I36.8 — Other nonrheumatic tricuspid valve disorders (tricuspid), I37.8 — Other nonrheumatic pulmonary valve disorders (pulmonary valve), I42.4 — Endocardial fibroelastosis (subendocardial, congenital), I44.39 — Other atrioventricular block (bundle of His), I51.4 — Myocarditis, unspecified (myocarditis), I65.2 — Occlusion and stenosis of carotid artery (carotid), I67.2 — Cerebral atherosclerosis (carotid), +288 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Blood Glucose Test, Lipid Panel, Prothrombin Time Test and INR (PT/INR)

Contextual Map

Every relationship of I25.10 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run I25.10 with these 10 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Excludes2 notes

Referenced by Code First instructions

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 05 — Diseases and Disorders of the Circulatory System[MDC crossing]: “Diseases and Disorders of the Circulatory System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 17,209 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

  • Arteriosclerosis, arteriosclerotic (diffuse) (obliterans) (of) (senile) (with calcification), coronary (artery)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Atheroma, atheromatous, coronary (artery)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Atherosclerosis, coronary, artery[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Disease, diseased, artery, coronary[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Disease, diseased, cardiovascular (atherosclerotic)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Disease, diseased, heart (organic), ischemic (chronic or with a stated duration of over 4 weeks), atherosclerotic (of)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Sclerosis, sclerotic, coronary (artery)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (40)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Atherosclerotic heart disease of native coronary artery without angina pectoris

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to I25.10 in its code family, with their registry titles.

View all codes in the I25 family