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K21.00 ICD-10-CM Code: Gastro-esophageal reflux disease with esophagitis, without bleeding

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0, Appendix B.

  • MS-DRG 391 — ESOPHAGITIS, GASTROENTERITIS AND MISCELLANEOUS DIGESTIVE DISORDERS WITH MCC (MDC 06)
  • MS-DRG 392 — ESOPHAGITIS, GASTROENTERITIS AND MISCELLANEOUS DIGESTIVE DISORDERS WITHOUT MCC (MDC 06)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Official Registry Overview & Definition

Gastro-esophageal reflux disease with esophagitis, without bleeding is a billable ICD-10-CM diagnosis code (K21.00).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for K21.00 in the official ICD-10-CM tabular list.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Reflux esophagitis

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Frequently Compared Codes

The official Excludes notes on K21.00 name these codes. Each comparison page covers when the two can — or must not — be reported together.

Change history

  • FY2021 — 2020-10-01
    Added to the code set
    Gastro-esophageal reflux disease with esophagitis, without bleeding
    FY2021 changes

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Contextual Map

Every relationship of K21.00 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

  • K00-K95 — Chapter 11: Diseases of the Digestive System (K00-K95) (K00-K95) [Hierarchy]
  • K20-K31 — Diseases of esophagus, stomach and duodenum [Hierarchy]

Referenced by Excludes1 notes

  • K20 — Esophagitis [Excludes1](via K21.0.-): “esophagitis with gastro-esophageal reflux disease (K21.0-)” · check together

Referenced by Code Also instructions

  • R63.31 — Pediatric feeding disorder, acute [Code Also](via K21.-): “gastro-esophageal reflux disease (K21.-)” · check together
  • R63.32 — Pediatric feeding disorder, chronic [Code Also](via K21.-): “gastro-esophageal reflux disease (K21.-)” · check together

Clinical classification (CCSR)

  • DIG004 — Esophageal disorders [CCSR]

Potential MS-DRG

  • DRG 391 — ESOPHAGITIS, GASTROENTERITIS AND MISCELLANEOUS DIGESTIVE DISORDERS WITH MCC [MS-DRG]: “ESOPHAGITIS, GASTROENTERITIS AND MISCELLANEOUS DIGESTIVE DISORDERS WITH MCC (MDC 06)”
  • DRG 392 — ESOPHAGITIS, GASTROENTERITIS AND MISCELLANEOUS DIGESTIVE DISORDERS WITHOUT MCC [MS-DRG]: “ESOPHAGITIS, GASTROENTERITIS AND MISCELLANEOUS DIGESTIVE DISORDERS WITHOUT MCC (MDC 06)”

MDC crossing · procedures (5744)

  • MDC 06 — Diseases and Disorders of the Digestive System [MDC crossing]: “Diseases and Disorders of the Digestive System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”
  • 008Q0ZZ — Division of Vagus Nerve, Open Approach [Same-MDC procedure]: “Division of Vagus Nerve, Open Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • 008Q3ZZ — Division of Vagus Nerve, Percutaneous Approach [Same-MDC procedure]: “Division of Vagus Nerve, Percutaneous Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • 008Q4ZZ — Division of Vagus Nerve, Percutaneous Endoscopic Approach [Same-MDC procedure]: “Division of Vagus Nerve, Percutaneous Endoscopic Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • 02BP3ZZ — Excision of Pulmonary Trunk, Percutaneous Approach [Same-MDC procedure]: “Excision of Pulmonary Trunk, Percutaneous Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • 02BQ3ZZ — Excision of Right Pulmonary Artery, Percutaneous Approach [Same-MDC procedure]: “Excision of Right Pulmonary Artery, Percutaneous Approach — grouped in MDC 06, the procedure side of this code's crossing.” · check together
  • and 5739 more

Index entries

  • Allergy, allergic (reaction) (to), milk protein, gastroesophageal reflux, with esophagitis (without bleeding)[Index term]
  • Disease, diseased, gastroesophageal reflux (GERD), with esophagitis (without bleeding)[Index term]
  • Esophagitis (acute) (alkaline) (chemical) (chronic) (infectional) (necrotic) (peptic) (postoperative) (without bleeding), due to gastrointestinal reflux disease (without bleeding)[Index term]
  • Esophagitis (acute) (alkaline) (chemical) (chronic) (infectional) (necrotic) (peptic) (postoperative) (without bleeding), reflux[Index term]
  • Reflux, esophageal, with esophagitis (without bleeding)[Index term]
  • Reflux, gastroesophageal, with esophagitis (without bleeding)[Index term]
  • Ulcer, ulcerated, ulcerating, ulceration, ulcerative, esophagus (peptic), due to, gastrointestinal reflux disease (without bleeding)[Index term]

Nearest codes

  • K21 — Gastro-esophageal reflux disease [Sibling]
  • K21.0 — Gastro-esophageal reflux disease with esophagitis [Sibling]
  • K21.01 — Gastro-esophageal reflux disease with esophagitis, with bleeding [Sibling]
  • K21.9 — Gastro-esophageal reflux disease without esophagitis [Sibling]

Change history

  • FY2021 — Added to the code set [Change history]

Referenced by Other Codes

Clinical classification (AHRQ CCSR):DIG004 — Esophageal disorders (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Potential MS-DRG Relationships (FY2026)

Not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity.

Named in the grouper logic of 2 MS-DRGs: DRG 391 (MDC 06), DRG 392 (MDC 06).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Official ICD-10-CM tabular notes on other codes that name K21.00 or its code family.

1 Excludes1 notes: K20 (via K21.0.-).

2 Code Also instructions: R63.31 (via K21.-), R63.32 (via K21.-).

Nearest Codes in This Family

Official ICD-10-CM classifications closest to K21.00 in its code family, with their registry titles.

  • K21 — Gastro-esophageal reflux disease
  • K21.0 — Gastro-esophageal reflux disease with esophagitis
  • K21.01 — Gastro-esophageal reflux disease with esophagitis, with bleeding
  • K21.9 — Gastro-esophageal reflux disease without esophagitis

View all codes in the K21 family

Indexed Clinical Terms (7)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Allergy, allergic (reaction) (to), milk protein, gastroesophageal reflux, with esophagitis (without bleeding)
  • Disease, diseased, gastroesophageal reflux (GERD), with esophagitis (without bleeding)
  • Esophagitis (acute) (alkaline) (chemical) (chronic) (infectional) (necrotic) (peptic) (postoperative) (without bleeding), due to gastrointestinal reflux disease (without bleeding)
  • Esophagitis (acute) (alkaline) (chemical) (chronic) (infectional) (necrotic) (peptic) (postoperative) (without bleeding), reflux
  • Reflux, esophageal, with esophagitis (without bleeding)
  • Reflux, gastroesophageal, with esophagitis (without bleeding)
  • Ulcer, ulcerated, ulcerating, ulceration, ulcerative, esophagus (peptic), due to, gastrointestinal reflux disease (without bleeding)