M04 ICD-10-CM Code: Autoinflammatory syndromes
Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.
Coding at a Glance
- Tabular directives
- 1 Excludes2
Coding instructions
Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for M04 in the official ICD-10-CM tabular list, quoted as published.
Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025
Notes without a marker are published on M04 itself; “inherited from” names the category or block whose note applies here.
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- Crohn's disease (K50.-) Compare M04 vs K50 →
Coder workflow for M04
MedCoder structured workflow — derived from this code’s own official record
Before you code M04
- M04 is not reportable as written. Select the more specific code beneath it that the documentation supports. Codes are reported to the highest level of specificity the classification provides (Guidelines I.B.2).
ReviewM04.1, M04.2, M04.3, M04.8, M04.9
See the relationships section · Guide: How to choose an ICD-10-CM code →
Choose the right path
- Does the documentation support one of the more specific codes beneath M04?
Yes → Select that code and continue the checks below on its own page.
No → M04 cannot be reported as written; query for the specificity its subcategory needs.
Consider M04. Then confirm the code is valid for the date of service in the Verify section.
Documentation check
- The provider’s diagnostic statement
- Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
Official instructions as workflow
Excludes2 — not part of M04(1 note)
Coding workflow: The conditions named in this note are not included in M04. When the record documents both, both may be reported; the note is a boundary, not a prohibition.
CompareK50
See the official tabular notes · Guidelines I.A.12.b
Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.
Code Overview
MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.
Verify Before Coding
From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.
Relationships & Classification
MedCoder structured relationships — computed from published CMS and AHRQ datasets
Other codes that name M04 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.
Referenced by 1 Code Also instruction: E85.0 — Non-neuropathic heredofamilial amyloidosis.
These codes suggest coding this condition alongside when both are present.
Contextual Map
Every relationship of M04 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.
Run M04 with these 2 related codes in Claim Check
Hierarchy
- M00-M99 — Chapter 13: Diseases of the Musculoskeletal System and Connective Tissue (M00-M99) (M00-M99)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- M00-M25 — Arthropathies[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- M04-M04 — Autoinflammatory syndromes[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
Excludes2
- K50 — Crohn's disease [regional enteritis][Excludes2]: “Crohn's disease (K50.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Referenced by Code Also instructions
- E85.0 — Non-neuropathic heredofamilial amyloidosis[Code Also]: “autoinflammatory syndromes (M04.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Nearest codes
- M04.1 — Periodic fever syndromes[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- M04.2 — Cryopyrin-associated periodic syndromes[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- M04.3 — VEXAS syndrome[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- M04.8 — Other autoinflammatory syndromes[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- M04.9 — Autoinflammatory syndrome, unspecified[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
Change history
- FY2017 — Added to the code set[Change history]— CMS release files (code change ledger) · icd10cm-fy2017
Common coding questions
Can M04 be billed directly?
No. M04 (Autoinflammatory syndromes) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.
Sources for this page
Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.
- Code, title, tabular notes and index terms Official source data
- CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
- Claim edits Official source data
- CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
- Change history and date-of-service validity Official source data
- CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
- Comparisons, relationships and the contextual map MedCoder structured relationship
- Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
- Summary and FAQ answers MedCoder explanation
- Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.
Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates
Cite this page
Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.
MedCoder.ai. "M04 — Autoinflammatory syndromes." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/m04-autoinflammatory-syndromes
Change history
- FY2017 — October 1, 2016Added to the code setAutoinflammatory syndromesFY2017 changes
Nearest Codes in This Family
Official ICD-10-CM classifications closest to M04 in its code family, with their registry titles.