P58.4 ICD-10-CM Code: Neonatal jaundice due to drugs or toxins transmitted from mother or given to newborn
Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.
Coding at a Glance
- Tabular directives
- 6 Excludes1 · 1 use-additional code · 1 code-first instruction
Coding instructions
Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for P58.4 in the official ICD-10-CM tabular list, quoted as published.
Notes without a marker are published on P58.4 itself; “inherited from” names the category or block whose note applies here.
Excludes1 — Not Coded Here
Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
- jaundice due to isoimmunization (P55-P57) inherited from P58Compare P58.4 vs P55 →
- congenital stenosis and stricture of bile ducts (Q44.3) inherited from P50-P61Compare P58.4 vs Q44.3 →
- Crigler-Najjar syndrome (E80.5) inherited from P50-P61Compare P58.4 vs E80.5 →
- Dubin-Johnson syndrome (E80.6) inherited from P50-P61Compare P58.4 vs E80.6 →
- Gilbert syndrome (E80.4) inherited from P50-P61Compare P58.4 vs E80.4 →
- hereditary hemolytic anemias (D55-D58) inherited from P50-P61Compare P58.4 vs D55 →
Code First
Underlying conditions that must be sequenced before this code.
- poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)
Use Additional Code
Supplementary codes the tabular list directs you to add.
- Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
Coder workflow for P58.4
MedCoder structured workflow — derived from this code’s own official record
Before you code P58.4
- P58.4 is not reportable as written. Select the more specific code beneath it that the documentation supports. Codes are reported to the highest level of specificity the classification provides (Guidelines I.B.2).
See the relationships section · Guide: How to choose an ICD-10-CM code →
- P58.4’s title joins a condition with an associated condition or complication. Confirm each component is documented. Where the classification presumes the link through the “with” convention, only a provider statement that the conditions are unrelated defeats it. A combination code is assigned only when it fully identifies the documented conditions; a required second code for the stage, type or manifestation is still reported when the notes ask for it (Guidelines I.B.9, I.A.15).
- Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with P58.4. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).
Choose the right path
- Does the documentation support one of the more specific codes beneath P58.4?
Yes → Select that code and continue the checks below on its own page.
No → P58.4 cannot be reported as written; query for the specificity its subcategory needs. - Does the documentation support a condition named in P58.4’s Excludes1 note?
Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
No → Continue. - Is the underlying (etiologic) condition the Code First note names documented?
Yes → Sequence the underlying condition first, then P58.4.
No → Continue; do not add an underlying condition the record does not document.
Consider P58.4. Then work the Use Additional Code note, and confirm the code is valid for the date of service in the Verify section.
Documentation check
- The provider’s diagnostic statement
- Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
- The associated condition or complication
- Whether the associated condition the title names is documented; the “with” convention presumes some links, and a provider statement that the conditions are unrelated defeats it (Guidelines I.A.15).
- The underlying (etiologic) condition
- Named in the Code First note; sequenced before this code when documented (Guidelines I.A.13).
- The conditions the Use Additional Code note names
- Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.
Official instructions as workflow
Excludes1 — check before selecting P58.4(6 notes)
Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with P58.4: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.
CompareQ44.3, E80.5, E80.6, E80.4
See the official tabular notes · Guidelines I.A.12.a
Code First — sequencing check(1 note)
Coding workflow: Check whether the underlying or etiologic condition the note names is documented. When it is, sequence it before P58.4. Do not add an underlying condition the record does not document.
See the official tabular notes · Guidelines I.A.13
Use Additional Code — after identifying P58.4(1 note)
Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with P58.4 when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.
See the official tabular notes · Guidelines I.A.13
Coding decision scenarios
Pattern scenarios for this code’s structure — decision rules, not clinical cases
Documentation: Both the condition P58.4 describes and a condition named in its Excludes1 note are documented for the same encounter.
Coding question: Can both codes be reported?
Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.
Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).
Documentation: Only one of the components this code’s title joins is documented.
Coding question: Is P58.4 supported?
Path: Review the code for the documented component on its own.
Reason: A combination code is assigned only when it fully identifies the documented conditions; otherwise the documented component takes its own code (Guidelines I.B.9).
Documentation: The underlying condition the Code First note names is documented alongside this condition.
Coding question: How are the two sequenced?
Path: Review the Code First note.
Reason: The underlying condition is sequenced first and the manifestation follows (Guidelines I.A.13).
Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.
Code Overview
MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.
Decision Points
The directives on this code's own record, as a pre-claim checklist.
- Sequencing: 1 Code First instruction — the underlying condition is sequenced before this code when present. See the Code First notes
- 1 Use Additional Code instruction — report the named additional code(s) when the documentation supports them. See the Use Additional Code notes
- 6 Excludes1 entries — codes named there are generally not reported together with this code (Guidelines I.A.12.a). See the Excludes1 notes
Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.
Verify Before Coding
From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.
Relationships & Classification
MedCoder structured relationships — computed from published CMS and AHRQ datasets
Other codes that name P58.4 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.
Referenced by 3 Excludes1 notes across 3 chapters: K72 — Hepatic failure, not elsewhere classified (via P58.-), P93 — Reactions and intoxications due to drugs administered to newborn, R17 — Unspecified jaundice (via P58.-).
These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.
Referenced by 11 Excludes2 notes across 2 chapters: P04 — Newborn affected by noxious substances transmitted via placenta or breast milk, R70 — Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity (via P58.-), R70-R79 — Abnormal findings on examination of blood, without diagnosis (R70-R79) (via P58.-), R71 — Abnormality of red blood cells (via P58.-), R73 — Elevated blood glucose level (via P58.-), R74 — Abnormal serum enzyme levels (via P58.-), R75 — Inconclusive laboratory evidence of human immunodeficiency virus [HIV] (via P58.-), R76 — Other abnormal immunological findings in serum (via P58.-), R77 — Other abnormalities of plasma proteins (via P58.-), R78 — Findings of drugs and other substances, not normally found in blood (via P58.-), R79 — Other abnormal findings of blood chemistry (via P58.-).
These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.
Referenced by 1 Code Also instruction: K76.82 — Hepatic encephalopathy (via P58.-).
These codes suggest coding this condition alongside when both are present.
Contextual Map
Every relationship of P58.4 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.
Run P58.4 with these 20 related codes in Claim Check
Hierarchy
- P00-P96 — Chapter 16: Certain Conditions Originating in the Perinatal Period (P00-P96) (P00-P96)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- P50-P61 — Hemorrhagic and hematological disorders of newborn[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
Code First (30)
- T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics[Code First]: “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics[Code First]: “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified[Code First]: “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics[Code First]: “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens][Code First]: “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T41 — Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases[Code First]: “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T42 — Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs[Code First]: “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T43 — Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified[Code First]: “poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- and 22 more
Use Additional Code (15)
- T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens][Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T41 — Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T42 — Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T43 — Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- and 7 more
Referenced by Excludes1 notes
- K72 — Hepatic failure, not elsewhere classified[Excludes1](via P58.-): “icterus of newborn (P55-P59)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- P93 — Reactions and intoxications due to drugs administered to newborn[Excludes1]: “jaundice due to drugs or toxins transmitted from mother or given to newborn (P58.4-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- R17 — Unspecified jaundice[Excludes1](via P58.-): “neonatal jaundice (P55, P57-P59)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Referenced by Excludes2 notes (11)
- P04 — Newborn affected by noxious substances transmitted via placenta or breast milk[Excludes2]: “neonatal jaundice from excessive hemolysis due to drugs or toxins transmitted from mother (P58.4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- R70 — Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity[Excludes2](via P58.-): “hemorrhagic and hematological disorders of newborn (P50-P61)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- R70-R79 — Abnormal findings on examination of blood, without diagnosis (R70-R79)[Excludes2](via P58.-): “hemorrhagic and hematological disorders of newborn (P50-P61)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- R71 — Abnormality of red blood cells[Excludes2](via P58.-): “hemorrhagic and hematological disorders of newborn (P50-P61)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- R73 — Elevated blood glucose level[Excludes2](via P58.-): “hemorrhagic and hematological disorders of newborn (P50-P61)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- R74 — Abnormal serum enzyme levels[Excludes2](via P58.-): “hemorrhagic and hematological disorders of newborn (P50-P61)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- R75 — Inconclusive laboratory evidence of human immunodeficiency virus [HIV][Excludes2](via P58.-): “hemorrhagic and hematological disorders of newborn (P50-P61)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- R76 — Other abnormal immunological findings in serum[Excludes2](via P58.-): “hemorrhagic and hematological disorders of newborn (P50-P61)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- and 3 more
Referenced by Code Also instructions
- K76.82 — Hepatic encephalopathy[Code Also](via P58.-): “icterus of newborn (P55-P59)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Nearest codes (10)
- P58 — Neonatal jaundice due to other excessive hemolysis[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- P58.0 — Neonatal jaundice due to bruising[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- P58.1 — Neonatal jaundice due to bleeding[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- P58.2 — Neonatal jaundice due to infection[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- P58.3 — Neonatal jaundice due to polycythemia[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- P58.41 — Neonatal jaundice due to drugs or toxins transmitted from mother[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- P58.42 — Neonatal jaundice due to drugs or toxins given to newborn[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- P58.5 — Neonatal jaundice due to swallowed maternal blood[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- and 2 more
Change history
- FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016
Common coding questions
Can P58.4 be billed directly?
No. P58.4 (Neonatal jaundice due to drugs or toxins transmitted from mother or given to newborn) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.
Sources for this page
Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.
- Code, title, tabular notes and index terms Official source data
- CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
- Claim edits Official source data
- CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
- Change history and date-of-service validity Official source data
- CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
- Comparisons, relationships and the contextual map MedCoder structured relationship
- Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
- Summary and FAQ answers MedCoder explanation
- Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.
Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates
Change history
- FY2016 — October 1, 2015In the code set at ICD-10-CM adoptionNeonatal jaundice due to drugs or toxins transmitted from mother or given to newborn
No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.
Nearest Codes in This Family
Official ICD-10-CM classifications closest to P58.4 in its code family, with their registry titles.
- P58 — Neonatal jaundice due to other excessive hemolysis
- P58.0 — Neonatal jaundice due to bruising
- P58.1 — Neonatal jaundice due to bleeding
- P58.2 — Neonatal jaundice due to infection
- P58.3 — Neonatal jaundice due to polycythemia
- P58.41 — Neonatal jaundice due to drugs or toxins transmitted from mother
- P58.42 — Neonatal jaundice due to drugs or toxins given to newborn
- P58.5 — Neonatal jaundice due to swallowed maternal blood
- P58.8 — Neonatal jaundice due to other specified excessive hemolysis
- P58.9 — Neonatal jaundice due to excessive hemolysis, unspecified