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E80.4 ICD-10-CM Code: Gilbert syndrome

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
1 inclusion term · 5 Excludes1 · 1 Excludes2

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

  • MS-DRG 441 — DISORDERS OF LIVER EXCEPT MALIGNANCY, CIRRHOSIS OR ALCOHOLIC HEPATITIS WITH MCC (MDC 07)
  • MS-DRG 442 — DISORDERS OF LIVER EXCEPT MALIGNANCY, CIRRHOSIS OR ALCOHOLIC HEPATITIS WITH CC (MDC 07)
  • MS-DRG 443 — DISORDERS OF LIVER EXCEPT MALIGNANCY, CIRRHOSIS OR ALCOHOLIC HEPATITIS WITHOUT CC/MCC (MDC 07)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for E80.4 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on E80.4 itself; “inherited from” names the category or block whose note applies here.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • defects of catalase and peroxidase

Source: inherited from E80

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Source: inherited from E70-E88

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Source: inherited from E70-E88

Coder workflow for E80.4

MedCoder structured workflow — derived from this code’s own official record

Before you code E80.4

  1. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with E80.4. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support a condition named in E80.4’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewE34.5, E25.0, D55, Q87.4, E29.1

Consider E80.4. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Official instructions as workflow

  • Excludes1 — check before selecting E80.4(5 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with E80.4: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareE34.5, E25.0, D55, Q87.4, E29.1

    See the official tabular notes · Guidelines I.A.12.a

  • Excludes2 — not part of E80.4(1 note)

    Coding workflow: The conditions named in this note are not included in E80.4. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    CompareQ79.6

    See the official tabular notes · Guidelines I.A.12.b

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition E80.4 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewE34.5, E25.0, D55, Q87.4, E29.1

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Gilbert syndrome is a billable ICD-10-CM diagnosis code (E80.4).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (7)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name E80.4 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 14 Excludes1 notes: P50 — Newborn affected by intrauterine (fetal) blood loss, P50-P61 — Hemorrhagic and hematological disorders of newborn (P50-P61), P51 — Umbilical hemorrhage of newborn, P52 — Intracranial nontraumatic hemorrhage of newborn, P53 — Hemorrhagic disease of newborn, P54 — Other neonatal hemorrhages, P55 — Hemolytic disease of newborn, P56 — Hydrops fetalis due to hemolytic disease, P57 — Kernicterus, P58 — Neonatal jaundice due to other excessive hemolysis, P59 — Neonatal jaundice from other and unspecified causes (via E80.-), P59 — Neonatal jaundice from other and unspecified causes, P60 — Disseminated intravascular coagulation of newborn, P61 — Other perinatal hematological disorders.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 4 Excludes2 notes across 2 chapters: G11 — Hereditary ataxia (via E80.-), G71 — Primary disorders of muscles (via E80.-), N25.0 — Renal osteodystrophy (via E80.-), N25.81 — Secondary hyperparathyroidism of renal origin (via E80.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 2 Code First instructions across 2 chapters: G63 — Polyneuropathy in diseases classified elsewhere (via E80.-), H42 — Glaucoma in diseases classified elsewhere (via E80.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 3 MS-DRGs: DRG 441 (MDC 07), DRG 442 (MDC 07), DRG 443 (MDC 07).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):END016 — Other specified and unspecified nutritional and metabolic disorders (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Other specified and unspecified nutritional and metabolic disorders).

E79.81 — Aicardi-Goutières syndrome, E79.82 — Hereditary xanthinuria, E79.89 — Other specified disorders of purine and pyrimidine metabolism, E79.9 — Disorder of purine and pyrimidine metabolism, unspecified, E80.0 — Hereditary erythropoietic porphyria, E80.1 — Porphyria cutanea tarda, E80.20 — Unspecified porphyria, E80.21 — Acute intermittent (hepatic) porphyria, E80.29 — Other porphyria, E80.3 — Defects of catalase and peroxidase, E80.5 — Crigler-Najjar syndrome, E80.6 — Other disorders of bilirubin metabolism, E80.7 — Disorder of bilirubin metabolism, unspecified, E83.00 — Disorder of copper metabolism, unspecified, E83.01 — Wilson's disease, E83.09 — Other disorders of copper metabolism, E83.10 — Disorder of iron metabolism, unspecified, E83.110 — Hereditary hemochromatosis, E83.111 — Hemochromatosis due to repeated red blood cell transfusions, E83.118 — Other hemochromatosis, +258 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Jaundice”; these codes share that main term but sit in a different category of the Tabular List.

A27.0 — Leptospirosis icterohemorrhagica (leptospiral), B15.0 — Hepatitis A with hepatic coma (febrile, with hepatic coma), B15.9 — Hepatitis A without hepatic coma (febrile), D58.0 — Hereditary spherocytosis (newborn, spherocytosis), D59.8 — Other acquired hemolytic anemias (acholuric, acquired), D59.9 — Acquired hemolytic anemia, unspecified (hemolytic), E03.1 — Congenital hypothyroidism without goiter (newborn, due to or associated with, hypothyroidism, congenital), E74.21 — Galactosemia (newborn, due to or associated with, galactosemia), E84.9 — Cystic fibrosis, unspecified (newborn, due to or associated with, mucoviscidosis), K72.90 — Hepatic failure, unspecified without coma (malignant), K72.91 — Hepatic failure, unspecified with coma (malignant, with coma), K83.1 — Obstruction of bile duct (obstructive), P55.0 — Rh isoimmunization of newborn (newborn, due to or associated with, Rh, antibodies), P55.1 — ABO isoimmunization of newborn (newborn, due to or associated with, ABO, antibodies), P55.8 — Other hemolytic diseases of newborn (newborn, due to or associated with, hemolytic disease, specified NEC), P55.9 — Hemolytic disease of newborn, unspecified (newborn, due to or associated with, hemolytic disease), P57.9 — Kernicterus, unspecified (nuclear, newborn), P58.0 — Neonatal jaundice due to bruising (newborn, due to or associated with, bruising), P58.1 — Neonatal jaundice due to bleeding (newborn, due to or associated with, bleeding), P58.2 — Neonatal jaundice due to infection (newborn, due to or associated with, infection), +14 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Gamma-glutamyl Transferase (GGT) Test

Contextual Map

Every relationship of E80.4 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run E80.4 with these 14 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes (14)

Referenced by Excludes2 notes

Referenced by Code First instructions

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 07 — Diseases and Disorders of the Hepatobiliary System and Pancreas[MDC crossing]: “Diseases and Disorders of the Hepatobiliary System and Pancreas — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 2,481 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

  • Bilirubinemia, familial nonhemolytic[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Cholemia, familial (simple) (congenital)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Cholemia, Gilbert's[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Gilbert's disease or syndrome[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Jaundice (yellow), familial nonhemolytic (congenital) (Gilbert)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Jaundice (yellow), newborn, due to or associated with, Gilbert syndrome[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Jaundice (yellow), nonhemolytic congenital familial (Gilbert)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (11)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "E80.4 — Gilbert syndrome." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/e80.4-gilbert-syndrome

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Gilbert syndrome

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to E80.4 in its code family, with their registry titles.

View all codes in the E80 family