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ICD-10/R59.0

R59.0 ICD-10-CM Code: Localized enlarged lymph nodes

R59.0 is the authoritative medical code for Localized enlarged lymph nodes. This classification is used in medical billing and clinical recording to specify the clinical criteria for localized enlarged lymph nodes (ICD-10-CM R59.0), ensuring healthcare documentation aligns with current federal coding standards.

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0 (FY2026), Appendix B.

  • MS-DRG 814 — RETICULOENDOTHELIAL AND IMMUNITY DISORDERS WITH MCC (MDC 16)
  • MS-DRG 815 — RETICULOENDOTHELIAL AND IMMUNITY DISORDERS WITH CC (MDC 16)
  • MS-DRG 816 — RETICULOENDOTHELIAL AND IMMUNITY DISORDERS WITHOUT CC/MCC (MDC 16)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.

Official Registry Overview & Definition

Localized enlarged lymph nodes is a billable ICD-10-CM diagnosis code (R59.0). Includes: swollen glands. Excludes1 (not coded here): lymphadenitis NOS (I88.9); acute lymphadenitis (L04.-); chronic lymphadenitis (I88.1); mesenteric (acute) (chronic) lymphadenitis (I88.0).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for R59.0 in the official ICD-10-CM tabular list.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • swollen glands

Excludes1 — Not Coded Here

Conditions that can never be reported with this code; the two are mutually exclusive.

  • lymphadenitis NOS (I88.9)
  • acute lymphadenitis (L04.-)
  • chronic lymphadenitis (I88.1)
  • mesenteric (acute) (chronic) lymphadenitis (I88.0)

Frequently Asked Questions (FAQ) & Clinical Guidance

What can't be coded together with R59.0?

Per official ICD-10-CM Excludes1 instructions, R59.0 must not be reported together with: lymphadenitis NOS (I88.9); acute lymphadenitis (L04.-); chronic lymphadenitis (I88.1); mesenteric (acute) (chronic) lymphadenitis (I88.0).

Nearest Codes in This Family

Official ICD-10-CM classifications closest to R59.0 in its code family, with their registry titles.

  • R59 — Enlarged lymph nodes
  • R59.1 — Generalized enlarged lymph nodes
  • R59.9 — Enlarged lymph nodes, unspecified

View all codes in the R59 family

Indexed Clinical Terms (13)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Adenopathy (lymph gland), inguinal
  • Adenopathy (lymph gland), localized
  • Adenopathy (lymph gland), mediastinal
  • Adenopathy (lymph gland), mesentery
  • Adenopathy (lymph gland), tracheobronchial
  • Enlargement, enlarged, lymph gland or node, localized
  • Hyperplasia, hyperplastic, cervical gland
  • Hypertrophy, hypertrophic, gland, glandular, localized
  • Hypertrophy, hypertrophic, hilus gland
  • Hypertrophy, hypertrophic, lymph, lymphatic gland, localized
  • Lymphadenopathy (generalized), localized
  • Swelling (of), cervical gland
  • Swelling (of), glands, localized