Z92.21 ICD-10-CM Code: Personal history of antineoplastic chemotherapy
Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.
Inpatient Payment Groups (MS-DRG)
MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0 (FY2026), Appendix B.
- MS-DRG 949 — AFTERCARE WITH CC/MCC (MDC 23)
- MS-DRG 950 — AFTERCARE WITHOUT CC/MCC (MDC 23)
A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.
Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.
Official Registry Overview & Definition
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for Z92.21 in the official ICD-10-CM tabular list.
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- long term (current) drug therapy (Z79.-)
- postprocedural states (Z98.-)
Code Also
Additional codes that may be required to fully describe the encounter.
- any follow-up examination (Z08-Z09)
Nearest Codes in This Family
Official ICD-10-CM classifications closest to Z92.21 in its code family, with their registry titles.
- Z92 — Personal history of medical treatment
- Z92.0 — Personal history of contraception
- Z92.2 — Personal history of drug therapy
- Z92.22 — Personal history of monoclonal drug therapy
- Z92.23 — Personal history of estrogen therapy
- Z92.24 — Personal history of steroid therapy
- Z92.240 — Personal history of inhaled steroid therapy
- Z92.241 — Personal history of systemic steroid therapy
- Z92.25 — Personal history of immunosuppression therapy
- Z92.26 — Personal history of immune checkpoint inhibitor therapy
Indexed Clinical Terms (2)
Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.
- History, personal (of), chemotherapy for neoplastic condition
- History, personal (of), drug therapy, antineoplastic chemotherapy