D57.412 vs D58

D57.412 (Sickle-cell thalassemia, unspecified, with splenic sequestration) compared with D58 (Other hereditary hemolytic anemias), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.

Relationship

Conflict

Excludes1 conflict

D57.412

Sickle-cell thalassemia, unspecified, with splenic sequestration

↔

D58

Other hereditary hemolytic anemias

Not coded here — these two are mutually exclusive.

“other hemoglobinopathies (D58.-)”

An Excludes1 note means the two conditions cannot occur together, so the pair should not be reported for the same encounter. The sole exception is when the conditions are documented as unrelated to each other.

Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a

Can these codes be reported together?

No — do not report together. D57.412 carries an Excludes1 note covering D58: “other hemoglobinopathies (D58.-)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Side by side

	D57.412Sickle-cell thalassemia, unspecified, with splenic sequestration	D58Other hereditary hemolytic anemias
Billing status	Billable	Non-billable header Report instead: D58.0, D58.1, D58.2, D58.8, D58.9
Classification	D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89)	D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89)
Definition	Sickle-cell thalassemia, unspecified, with splenic sequestration is a billable ICD-10-CM diagnosis code (D57.412).	Other hereditary hemolytic anemias is a non-billable ICD-10-CM category code (D58).
Use additional code	code for any associated fever (R50.81)	—

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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources