D57.453 vs D58
D57.453 (Sickle-cell thalassemia beta plus with cerebral vascular involvement) compared with D58 (Other hereditary hemolytic anemias), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. D57.453 carries an Excludes1 note covering D58: “other hemoglobinopathies (D58.-)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvement | D58Other hereditary hemolytic anemias | |
|---|---|---|
| Billing status | Billable | Non-billable header |
| Classification | D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) | D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) |
| Definition | Sickle-cell thalassemia beta plus with cerebral vascular involvement is a billable ICD-10-CM diagnosis code (D57.453). | Other hereditary hemolytic anemias is a non-billable ICD-10-CM category code (D58). |
| Includes | HbS-beta plus with cerebral vascular involvement Sickle-cell beta plus with cerebral vascular involvement | — |
| Use additional code | code for any associated fever (R50.81) | — |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources