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Compare/D70 vs R78

D70 vs R78

D70 (Neutropenia) compared with R78 (Findings of drugs and other substances, not normally found in blood), from the official CMS tabular data. Both may be reported when both conditions are documented (Excludes2).

Can these codes be reported together?

Yes, when both are documented. R78 carries an Excludes2 note covering D70: “abnormalities of white blood cells classified elsewhere (D70-D72)”

Excludes2 marks distinct conditions — both may be reported when both are documented.

Side by side

D70NeutropeniaR78Findings of drugs and other substances, not normally found in blood
Billing statusNon-billable header

Report instead: D70.0, D70.1, D70.2, D70.3, D70.4

Non-billable header

Report instead: R78.0, R78.1, R78.2, R78.3, R78.4

ClassificationD50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89)R00-R99 — Symptoms, Signs and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99)
DefinitionNeutropenia is a non-billable ICD-10-CM category code (D70).Findings of drugs and other substances, not normally found in blood is a non-billable ICD-10-CM category code (R78).
Includes
agranulocytosis
decreased absolute neurophile count (ANC)
Use additional code
code for any associated:
fever (R50.81)
code to identify any retained foreign body, if applicable (Z18.-)

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources