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Compare/E22 vs E24

E22 vs E24

E22 (Hyperfunction of pituitary gland) compared with E24 (Cushing's syndrome), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.

Can these codes be reported together?

No — do not report together. E22 carries an Excludes1 note covering E24: “Cushing's syndrome (E24.-)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Side by side

E22Hyperfunction of pituitary glandE24Cushing's syndrome
Billing statusNon-billable header

Report instead: E22.0, E22.1, E22.2, E22.8, E22.9

Non-billable header

Report instead: E24.0, E24.1, E24.2, E24.3, E24.4

ClassificationE00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89)E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89)
DefinitionHyperfunction of pituitary gland is a non-billable ICD-10-CM category code (E22).Cushing's syndrome is a non-billable ICD-10-CM category code (E24).
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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources