Skip to main content

E24.2 ICD-10-CM Code: Drug-induced Cushing's syndrome

Compare with another codeCheck this code on a claim

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
3 Excludes1 · 1 use-additional code
Risk adjustment
CMS-HCC V22 category 23 · RxHCC V08 category 43

Billable · FY2027A valid, specific ICD-10-CM code, reportable for dates of service in FY2027.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too; the Instructions section marks which is which.

Use additional codeReport with this code when documented
  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
Excludes1Never report with this code
  • congenital adrenal hyperplasia (E25.0)
  • galactorrhea (N64.3)
  • gynecomastia (N62)

Most relevant related codes MedCoder-derived

Read off the official notes above and this code’s own position in the tabular list. Which to report is a documentation question; Compare shows the two side by side.

CompareCheck ClaimView Related Codes

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 643 — ENDOCRINE DISORDERS WITH MCC (MDC 10)
  • MS-DRG 644 — ENDOCRINE DISORDERS WITH CC (MDC 10)
  • MS-DRG 645 — ENDOCRINE DISORDERS WITHOUT CC/MCC (MDC 10)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for E24.2 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Notes without a marker are published on E24.2 itself; “inherited from” names the category or block whose note applies here.

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Coder workflow for E24.2

MedCoder structured workflow — derived from this code’s own official record

Before you code E24.2

  1. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with E24.2. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support a condition named in E24.2’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewE25.0, N64.3, N62

Consider E24.2. Then work the Use Additional Code note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
The conditions the Use Additional Code note names
Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.

Official instructions as workflow

  • Excludes1 — check before selecting E24.2(3 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with E24.2: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareE25.0, N64.3, N62

    See the official tabular notes · Guidelines I.A.12.a

  • Use Additional Code — after identifying E24.2(1 note)

    Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with E24.2 when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.

    See the official tabular notes · Guidelines I.A.13

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition E24.2 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewE25.0, N64.3, N62

Documentation: A condition the Use Additional Code note names is documented.

Coding question: Is a second code reported with E24.2?

Path: Review the Use Additional Code note and the code it names.

Reason: The additional code is reported when the record documents the condition; a conditional instruction applies only when its condition is met (Guidelines I.A.13).

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Don’t confuse E24.2 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of E24.2 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • E25.0— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of congenital adrenal hyperplasia moves the case to E25.0; the two are not reported together unless documented as unrelated.

    Full comparison: E24.2 vs E25.0 →

  • N64.3— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of galactorrhea moves the case to N64.3; the two are not reported together unless documented as unrelated.

    Full comparison: E24.2 vs N64.3 →

  • N62— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of gynecomastia moves the case to N62; the two are not reported together unless documented as unrelated.

    Full comparison: E24.2 vs N62 →

  • E24.9— Specificity relationship (Review)

    Overlapping diagnoses in the same category.

    Overlapping codes in the same category — the documentation decides which is the more specific fit.

    What moves you there: A record that documents no more than “Cushing's syndrome, unspecified” takes E24.9; specificity in the record moves it back here.

    Full comparison: E24.2 vs E24.9 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Drug-induced Cushing's syndrome is a billable ICD-10-CM diagnosis code (E24.2).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Verify Before Coding

  • CC as a secondary diagnosis (FY2027). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name E24.2 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 2 Excludes1 notes: E22 — Hyperfunction of pituitary gland (via E24.-), E27.0 — Other adrenocortical overactivity (via E24.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 2 Code First instructions across 2 chapters: E08 — Diabetes mellitus due to underlying condition (via E24.-), G63 — Polyneuropathy in diseases classified elsewhere (via E24.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 23 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 3 MS-DRGs: DRG 643 (MDC 10), DRG 644 (MDC 10), DRG 645 (MDC 10).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):INJ030 — Drug induced or toxic related condition (default); END015 — Other specified and unspecified endocrine disorders.

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

E24.0 — Pituitary-dependent Cushing's disease, E24.3 — Ectopic ACTH syndrome, E24.4 — Alcohol-induced pseudo-Cushing's syndrome, E24.8 — Other Cushing's syndrome, E24.9 — Cushing's syndrome, unspecified, E25.0 — Congenital adrenogenital disorders associated with enzyme deficiency, E25.8 — Other adrenogenital disorders, E25.9 — Adrenogenital disorder, unspecified, E26.01 — Conn's syndrome, E26.02 — Glucocorticoid-remediable aldosteronism, E26.09 — Other primary hyperaldosteronism, E26.1 — Secondary hyperaldosteronism, E26.81 — Bartter's syndrome, E26.89 — Other hyperaldosteronism, E26.9 — Hyperaldosteronism, unspecified, E30.9 — Disorder of puberty, unspecified, E34.1 — Other hypersecretion of intestinal hormones, E34.50 — Androgen insensitivity syndrome, unspecified, E34.51 — Complete androgen insensitivity syndrome, E34.52 — Partial androgen insensitivity syndrome, +2 more

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical categories (Drug induced or toxic related condition, Other specified and unspecified endocrine disorders).

E20.89 — Other specified hypoparathyroidism, E20.9 — Hypoparathyroidism, unspecified, E21.0 — Primary hyperparathyroidism, E21.1 — Secondary hyperparathyroidism, not elsewhere classified, E21.2 — Other hyperparathyroidism, E21.3 — Hyperparathyroidism, unspecified, E21.4 — Other specified disorders of parathyroid gland, E21.5 — Disorder of parathyroid gland, unspecified, E23.1 — Drug-induced hypopituitarism, E24.1 — Nelson's syndrome, E24.3 — Ectopic ACTH syndrome, E24.4 — Alcohol-induced pseudo-Cushing's syndrome, E24.8 — Other Cushing's syndrome, E24.9 — Cushing's syndrome, unspecified, E25.0 — Congenital adrenogenital disorders associated with enzyme deficiency, E25.8 — Other adrenogenital disorders, E25.9 — Adrenogenital disorder, unspecified, E26.01 — Conn's syndrome, E26.02 — Glucocorticoid-remediable aldosteronism, E26.09 — Other primary hyperaldosteronism, +328 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Hyperadrenocorticism”, “Steroid”; these codes share that main term but sit in a different category of the Tabular List.

E25.0 — Congenital adrenogenital disorders associated with enzyme deficiency (congenital), E27.0 — Other adrenocortical overactivity (not associated with Cushing's syndrome), E27.3 — Drug-induced adrenocortical insufficiency (effects, insufficiency), H40.04 — Steroid responder (responder), R50.2 — Drug induced fever (effects, fever)

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Blood Glucose Test, Lipid Panel

Contextual Map

Every relationship of E24.2 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run E24.2 with these 12 related codes in Claim Check

Hierarchy

Use Additional Code (15)

Referenced by Excludes1 notes

Referenced by Code First instructions

Clinical classification (CCSR)

MS-DRG Grouper

  • CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”— CMS MS-DRG Definitions Manual (Appendix C) · FY2027
  • DRG 643 — ENDOCRINE DISORDERS WITH MCC[MS-DRG]: “ENDOCRINE DISORDERS WITH MCC (MDC 10)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
  • DRG 644 — ENDOCRINE DISORDERS WITH CC[MS-DRG]: “ENDOCRINE DISORDERS WITH CC (MDC 10)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
  • DRG 645 — ENDOCRINE DISORDERS WITHOUT CC/MCC[MS-DRG]: “ENDOCRINE DISORDERS WITHOUT CC/MCC (MDC 10)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027

MDC crossing

  • MDC 10 — Endocrine, Nutritional and Metabolic Diseases and Disorders[MDC crossing]: “Endocrine, Nutritional and Metabolic Diseases and Disorders — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 5,013 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Index entries (9)

  • Cushing's, syndrome or disease, drug-induced[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Cushing's, syndrome or disease, iatrogenic[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Cushingoid due to steroid therapy[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Hyperadrenocorticism, iatrogenic[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Hypercorticosteronism[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Hypercortisonism[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Steroid, effects (adverse) (adrenocortical) (iatrogenic), cushingoid[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Syndrome, Cushing's, drug-induced[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • and 1 more

Nearest codes

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Indexed Clinical Terms (9)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 20, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "E24.2 — Drug-induced Cushing's syndrome." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/e24.2-drug-induced-cushings-syndrome

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Drug-induced Cushing's syndrome

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to E24.2 in its code family, with their registry titles.

View all codes in the E24 family