E21.1 ICD-10-CM Code: Secondary hyperparathyroidism, not elsewhere classified
Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.
Inpatient Payment Groups (MS-DRG)
MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0 (FY2026), Appendix B.
- MS-DRG 643 — ENDOCRINE DISORDERS WITH MCC (MDC 10)
- MS-DRG 644 — ENDOCRINE DISORDERS WITH CC (MDC 10)
- MS-DRG 645 — ENDOCRINE DISORDERS WITHOUT CC/MCC (MDC 10)
A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.
Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.
Official Registry Overview & Definition
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for E21.1 in the official ICD-10-CM tabular list.
Excludes1 — Not Coded Here
Conditions that can never be reported with this code; the two are mutually exclusive.
- secondary hyperparathyroidism of renal origin (N25.81)
- adult osteomalacia (M83.-)
- ectopic hyperparathyroidism (E34.2)
- hungry bone syndrome (E83.81)
- infantile and juvenile osteomalacia (E55.0)
- galactorrhea (N64.3)
- gynecomastia (N62)
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- familial hypocalciuric hypercalcemia (E83.52)
Nearest Codes in This Family
Official ICD-10-CM classifications closest to E21.1 in its code family, with their registry titles.
Indexed Clinical Terms (2)
Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.
- Hyperparathyroidism, secondary (renal), non-renal
- Osteodystrophy, parathyroid, secondary