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ICD-10/E21.1

E21.1 ICD-10-CM Code: Secondary hyperparathyroidism, not elsewhere classified

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0 (FY2026), Appendix B.

  • MS-DRG 643 — ENDOCRINE DISORDERS WITH MCC (MDC 10)
  • MS-DRG 644 — ENDOCRINE DISORDERS WITH CC (MDC 10)
  • MS-DRG 645 — ENDOCRINE DISORDERS WITHOUT CC/MCC (MDC 10)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.

Official Registry Overview & Definition

Secondary hyperparathyroidism, not elsewhere classified is a billable ICD-10-CM diagnosis code (E21.1).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for E21.1 in the official ICD-10-CM tabular list.

Excludes1 — Not Coded Here

Conditions that can never be reported with this code; the two are mutually exclusive.

  • secondary hyperparathyroidism of renal origin (N25.81)
  • adult osteomalacia (M83.-)
  • ectopic hyperparathyroidism (E34.2)
  • hungry bone syndrome (E83.81)
  • infantile and juvenile osteomalacia (E55.0)
  • galactorrhea (N64.3)
  • gynecomastia (N62)

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

  • familial hypocalciuric hypercalcemia (E83.52)

Nearest Codes in This Family

Official ICD-10-CM classifications closest to E21.1 in its code family, with their registry titles.

  • E21 — Hyperparathyroidism and other disorders of parathyroid gland
  • E21.0 — Primary hyperparathyroidism
  • E21.2 — Other hyperparathyroidism
  • E21.3 — Hyperparathyroidism, unspecified
  • E21.4 — Other specified disorders of parathyroid gland
  • E21.5 — Disorder of parathyroid gland, unspecified

View all codes in the E21 family

Indexed Clinical Terms (2)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Hyperparathyroidism, secondary (renal), non-renal
  • Osteodystrophy, parathyroid, secondary