E72 vs R80

E72 (Other disorders of amino-acid metabolism) compared with R80 (Proteinuria), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.

Can these codes be reported together?

No — do not report together. R80 carries an Excludes1 note covering E72: “specific findings indicating disorder of amino-acid metabolism (E70-E72)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Side by side

	E72Other disorders of amino-acid metabolism	R80Proteinuria
Billing status	Non-billable header Report instead: E72.00, E72.01, E72.02, E72.03, E72.04	Non-billable header Report instead: R80.0, R80.1, R80.2, R80.3, R80.8
Classification	E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89)	R00-R99 — Symptoms, Signs and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99)
Definition	Other disorders of amino-acid metabolism is a non-billable ICD-10-CM category code (E72).	Proteinuria is a non-billable ICD-10-CM category code (R80).

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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources