E85 vs Q87.4

E85 (Amyloidosis) compared with Q87.4 (Marfan syndrome), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.

Can these codes be reported together?

No — do not report together. E85 carries an Excludes1 note covering Q87.4: “Marfan syndrome (Q87.4-)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Side by side

	E85Amyloidosis	Q87.4Marfan syndrome
Billing status	Non-billable header Report instead: E85.0, E85.1, E85.2, E85.3, E85.4	Non-billable header Report instead: Q87.40, Q87.410, Q87.418, Q87.42, Q87.43
Classification	E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89)	Q00-Q99 — Congenital Malformations, Deformations and Chromosomal Abnormalities (Q00-Q99)
Definition	Amyloidosis is a non-billable ICD-10-CM category code (E85).	Marfan syndrome is a non-billable ICD-10-CM category code (Q87.4).
Use additional code	—	code(s) to identify all associated manifestations

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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources