E88.0 vs R77
E88.0 (Disorders of plasma-protein metabolism, not elsewhere classified) compared with R77 (Other abnormalities of plasma proteins), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. R77 carries an Excludes1 note covering E88.0: “disorders of plasma-protein metabolism (E88.0-)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| E88.0Disorders of plasma-protein metabolism, not elsewhere classified | R77Other abnormalities of plasma proteins | |
|---|---|---|
| Billing status | Non-billable header | Non-billable header |
| Classification | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) | R00-R99 — Symptoms, Signs and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99) |
| Definition | Disorders of plasma-protein metabolism, not elsewhere classified is a non-billable ICD-10-CM category code (E88.0). | Other abnormalities of plasma proteins is a non-billable ICD-10-CM category code (R77). |
| Use additional code | codes for associated conditions | — |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources