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M81.0 vs N95.1

M81.0 (Age-related osteoporosis without current pathological fracture) compared with N95.1 (Menopausal and female climacteric states), from the official CMS tabular data.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Summary

These codes can be reported together when both conditions are documented, because N95.1 lists M81.0 under Excludes2, which marks them as distinct conditions.

Official rule
What is different?

The conditions named and chapter.M81.0 is “Age-related osteoporosis without current pathological fracture”; N95.1 is “Menopausal and female climacteric states”. M81.0 sits in M00-M99 — Diseases of the Musculoskeletal System and Connective Tissue (M00-M99); N95.1 in N00-N99 — Diseases of the Genitourinary System (N00-N99).

Registry fact

Can these codes be reported together?

Yes, when both are documented.N95.1 lists M81.0 under Excludes2: “postmenopausal osteoporosis (M81.0-)”. Excludes2 marks distinct conditions that may both be reported when both are documented.

Official ruleGuide: Excludes1 vs Excludes2

Is there an Excludes1 relationship?

None.Neither entry carries an Excludes1 note that names the other code. M81.0 carries 2 Excludes1 notes and N95.1 carries 6 Excludes1 notes covering other codes; the side-by-side table quotes them.

Official rule

Is there an Excludes2 relationship?

Yes.N95.1’s tabular entry: “postmenopausal osteoporosis (M81.0-)”. The note covers M81.0.

Official ruleGuide: Excludes1 vs Excludes2

Is one more specific?

Not comparable.The codes sit in different categories; specificity is only comparable within one category.

Is one a parent or header code?

No.Both are billable codes, and neither contains the other.

Registry fact

Are there sequencing instructions?

None.Neither entry carries a Code First or Use Additional Code note that names the other.

Official rule

Are there other coding relationships?

None found.No laterality, encounter-phase, Table of Neoplasms, Table of Drugs and Chemicals, or history-versus-active-disease relationship links these codes.

MedCoder-derived

Official rule: a tabular instructional note or a section of the ICD-10-CM Official Guidelines, quoted as published. Registry fact: the codes’ own published attributes (titles, billable status, position in the hierarchy, code set). MedCoder-derived: a reading MedCoder computes from those facts; it is not itself a rule. How to read the labels

Can these codes be reported together?

Informational

Excludes2 relationship

N95.1
Menopausal and female climacteric states
↔
M81.0
Age-related osteoporosis without current pathological fracture

What we found

Yes, when both are documented.N95.1 carries an Excludes2 note covering M81.0: “postmenopausal osteoporosis (M81.0-)”

Excludes2 marks distinct conditions — both may be reported when both are documented.

What to review

Report both only when the documentation supports both conditions; otherwise report the one documented.

Guide: Excludes1 vs Excludes2Check these on a claim

Why it matters

An Excludes2 note means the excluded condition is not part of the code above it, but a patient can have both. Report both when both are documented.

Source / rule

CMS ICD-10-CM tabular instructional notes

Official guidance behind these answers

  • Section I.A.12.b — Excludes2 · applies to: Excludes2

    A type 2 Excludes note represents “Not included here.” An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.

    ICD-10-CM Official Guidelines FY2027

Quoted from the ICD-10-CM Official Guidelines for Coding and Reporting in effect for the release shown. The tabular notes above are the code-level instruction; these sections are the convention that says how such a note is applied. Source document (CMS PDF) · Release and checksum

Side by side

Similar descriptions do not make codes interchangeable. The documentation and the official instructions decide which code applies.

Official descriptionDiffers
M81.0

Age-related osteoporosis without current pathological fracture

N95.1

Menopausal and female climacteric states

StatusSame for both
Billable
Excludes1Differs
M81.0
  • osteoporosis with current pathological fracture (M80.-)
  • Sudeck's atrophy (M89.0)
N95.1
  • asymptomatic menopausal state (Z78.0)
  • symptoms associated with artificial menopause (E89.41)
  • symptoms associated with premature menopause (E28.310)
  • excessive bleeding in the premenopausal period (N92.4)
  • menopausal and perimenopausal disorders due to artificial or premature menopause (E89.4-, E28.31-)
  • premature menopause (E28.31-)
Excludes2Differs
M81.0

None at this code

N95.1
  • postmenopausal osteoporosis (M81.0-)
  • postmenopausal osteoporosis with current pathological fracture (M80.0-)
  • postmenopausal urethritis (N34.2)
Use additional codeDiffers
M81.0
  • code to identify:
  • major osseous defect, if applicable (M89.7-)
  • personal history of (healed) osteoporosis fracture, if applicable (Z87.310)
N95.1
  • code for associated symptoms
CategoryDiffers
M81.0

M81 Osteoporosis without current pathological fracture

N95.1

N95 Menopausal and other perimenopausal disorders

ChapterDiffers
M81.0

M00-M99 — Diseases of the Musculoskeletal System and Connective Tissue (M00-M99)

N95.1

N00-N99 — Diseases of the Genitourinary System (N00-N99)

IncludesDiffers
M81.0
  • Involutional osteoporosis without current pathological fracture
  • Osteoporosis NOS
  • Postmenopausal osteoporosis without current pathological fracture
  • Senile osteoporosis without current pathological fracture
N95.1
  • Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with natural (age-related) menopause

No Code first, Code also and 7th character note at either code.

Notes are the code’s own tabular entry, quoted as published. A note that names the other code is the one the verdict above rests on. In a row that differs, notes every code shares are dimmed.

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Derived from the official CMS ICD-10-CM tabular data (FY2027). A coding-rule comparison, not billing advice: payer-specific edits and medical-necessity policy are outside its scope. All data sources