E25 ICD-10-CM Code: Adrenogenital disorders
Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.
Coding at a Glance
- Tabular directives
- 7 inclusion terms · 4 Excludes1
Coding instructions
Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for E25 in the official ICD-10-CM tabular list, quoted as published.
Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025
Notes without a marker are published on E25 itself; “inherited from” names the category or block whose note applies here.
Includes
Conditions the official ICD-10-CM tabular list includes under this code.
- adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesis
- Female adrenal pseudohermaphroditism
- Female heterosexual precocious pseudopuberty
- Male isosexual precocious pseudopuberty
- Male macrogenitosomia praecox
- Male sexual precocity with adrenal hyperplasia
- Male virilization (female)
Excludes1 — Not Coded Here
Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
- indeterminate sex and pseudohermaphroditism (Q56) Compare E25 vs Q56 →
- chromosomal abnormalities (Q90-Q99) Compare E25 vs Q90 →
- galactorrhea (N64.3) inherited from E20-E35Compare E25 vs N64.3 →
- gynecomastia (N62) inherited from E20-E35Compare E25 vs N62 →
Coder workflow for E25
MedCoder structured workflow — derived from this code’s own official record
Before you code E25
- E25 is not reportable as written. Select the more specific code beneath it that the documentation supports. Codes are reported to the highest level of specificity the classification provides (Guidelines I.B.2).
See the relationships section · Guide: How to choose an ICD-10-CM code →
- Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with E25. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).
Choose the right path
- Does the documentation support one of the more specific codes beneath E25?
Yes → Select that code and continue the checks below on its own page.
No → E25 cannot be reported as written; query for the specificity its subcategory needs. - Does the documentation support a condition named in E25’s Excludes1 note?
Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
No → Continue.
Consider E25. Then confirm the code is valid for the date of service in the Verify section.
Documentation check
- The provider’s diagnostic statement
- Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
Official instructions as workflow
Excludes1 — check before selecting E25(4 notes)
Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with E25: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.
See the official tabular notes · Guidelines I.A.12.a
Coding decision scenarios
Pattern scenarios for this code’s structure — decision rules, not clinical cases
Documentation: Both the condition E25 describes and a condition named in its Excludes1 note are documented for the same encounter.
Coding question: Can both codes be reported?
Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.
Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).
Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.
Code Overview
MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.
Verify Before Coding
From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.
Relationships & Classification
MedCoder structured relationships — computed from published CMS and AHRQ datasets
Other codes that name E25 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.
Referenced by 3 Excludes1 notes across 2 chapters: E30.1 — Precocious puberty, Q56 — Indeterminate sex and pseudohermaphroditism, Q89.1 — Congenital malformations of adrenal gland.
These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.
Referenced by 1 Code First instruction: G63 — Polyneuropathy in diseases classified elsewhere.
Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.
Contextual Map
Every relationship of E25 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.
Run E25 with these 11 related codes in Claim Check
Hierarchy
- E00-E89 — Chapter 4: Endocrine, Nutritional and Metabolic Diseases (E00-E89) (E00-E89)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- E20-E35 — Disorders of other endocrine glands[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
Excludes1 (12)
- N62 — Hypertrophy of breast[Excludes1]: “gynecomastia (N62)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- N64.3 — Galactorrhea not associated with childbirth[Excludes1]: “galactorrhea (N64.3)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- Q56 — Indeterminate sex and pseudohermaphroditism[Excludes1]: “indeterminate sex and pseudohermaphroditism (Q56)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- Q90 — Down syndrome[Excludes1]: “chromosomal abnormalities (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- Q91 — Trisomy 18 and Trisomy 13[Excludes1]: “chromosomal abnormalities (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- Q92 — Other trisomies and partial trisomies of the autosomes, not elsewhere classified[Excludes1]: “chromosomal abnormalities (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- Q93 — Monosomies and deletions from the autosomes, not elsewhere classified[Excludes1]: “chromosomal abnormalities (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- Q95 — Balanced rearrangements and structural markers, not elsewhere classified[Excludes1]: “chromosomal abnormalities (Q90-Q99)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- and 4 more
Referenced by Excludes1 notes
- E30.1 — Precocious puberty[Excludes1]: “female heterosexual precocious pseudopuberty (E25.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- Q56 — Indeterminate sex and pseudohermaphroditism[Excludes1]: “female pseudohermaphroditism with adrenocortical disorder (E25.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- Q89.1 — Congenital malformations of adrenal gland[Excludes1]: “adrenogenital disorders (E25.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Referenced by Code First instructions
- G63 — Polyneuropathy in diseases classified elsewhere[Code First]: “endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Nearest codes
- E25.0 — Congenital adrenogenital disorders associated with enzyme deficiency[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- E25.8 — Other adrenogenital disorders[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- E25.9 — Adrenogenital disorder, unspecified[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
Change history
- FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016
Common coding questions
Can E25 be billed directly?
No. E25 (Adrenogenital disorders) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.
Sources for this page
Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.
- Code, title, tabular notes and index terms Official source data
- CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
- Claim edits Official source data
- CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
- Change history and date-of-service validity Official source data
- CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
- Comparisons, relationships and the contextual map MedCoder structured relationship
- Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
- Summary and FAQ answers MedCoder explanation
- Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.
Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates
Change history
- FY2016 — October 1, 2015In the code set at ICD-10-CM adoptionAdrenogenital disorders
No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.
Nearest Codes in This Family
Official ICD-10-CM classifications closest to E25 in its code family, with their registry titles.