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E85.8 ICD-10-CM Code: Other amyloidosis

Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.

Coding at a Glance

Tabular directives
5 Excludes1 · 2 Excludes2

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for E85.8 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on E85.8 itself; “inherited from” names the category or block whose note applies here.

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Source: inherited from E70-E88

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Coder workflow for E85.8

MedCoder structured workflow — derived from this code’s own official record

Before you code E85.8

  1. E85.8 is not reportable as written. Select the more specific code beneath it that the documentation supports. Codes are reported to the highest level of specificity the classification provides (Guidelines I.B.2).

    ReviewE85.81, E85.82, E85.89

    See the relationships section · Guide: How to choose an ICD-10-CM code →

  2. “Other” (NEC) means the condition is specified in the record but no dedicated code captures it. Confirm the documented form is not one a sibling code names before settling on E85.8; if the record states no specifics at all, the unspecified sibling applies instead. “Other” codes are for documented conditions the classification gives no specific code; “unspecified” codes are for records lacking the detail (Guidelines I.A.9.a, I.A.9.b).

    ReviewE85.0, E85.1, E85.3, E85.4

    See the relationships section · Guide: Other vs unspecified (NEC vs NOS) →

  3. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with E85.8. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support one of the more specific codes beneath E85.8?
    Yes → Select that code and continue the checks below on its own page.
    No → E85.8 cannot be reported as written; query for the specificity its subcategory needs.

    ReviewE85.81, E85.82, E85.89

  2. Does the documentation support a condition named in E85.8’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewE34.5, E25.0, D55, Q87.4, E29.1

Consider E85.8. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
Any detail beyond this code’s title
What the record states that a more specific sibling code would capture — or its absence, which itself supports the unspecified code.

Official instructions as workflow

  • Excludes1 — check before selecting E85.8(5 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with E85.8: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareE34.5, E25.0, D55, Q87.4, E29.1

    See the official tabular notes · Guidelines I.A.12.a

  • Excludes2 — not part of E85.8(2 notes)

    Coding workflow: The conditions named in this note are not included in E85.8. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    CompareG30.0, Q79.6

    See the official tabular notes · Guidelines I.A.12.b

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition E85.8 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewE34.5, E25.0, D55, Q87.4, E29.1

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Other amyloidosis is a non-billable ICD-10-CM category code (E85.8). A more specific billable subcode must be selected for claims submission.

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Verify Before Coding

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name E85.8 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 7 Excludes1 notes across 3 chapters: E27.1 — Primary adrenocortical insufficiency (via E85.-), M60 — Myositis (via E85.-), M60-M63 — Disorders of muscles (M60-M63) (via E85.-), M61 — Calcification and ossification of muscle (via E85.-), M62 — Other disorders of muscle (via E85.-), M63 — Disorders of muscle in diseases classified elsewhere (via E85.-), P59 — Neonatal jaundice from other and unspecified causes (via E85.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 6 Excludes2 notes across 3 chapters: G11 — Hereditary ataxia (via E85.-), G71 — Primary disorders of muscles (via E85.-), K76 — Other diseases of liver (via E85.-), N07 — Hereditary nephropathy, not elsewhere classified (via E85.-), N25.0 — Renal osteodystrophy (via E85.-), N25.81 — Secondary hyperparathyroidism of renal origin (via E85.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 15 Code First instructions across 9 chapters: D77 — Other disorders of blood and blood-forming organs in diseases classified elsewhere (via E85.-), G32.8 — Other specified degenerative disorders of nervous system in diseases classified elsewhere (via E85.-), G63 — Polyneuropathy in diseases classified elsewhere (via E85.-), G99.0 — Autonomic neuropathy in diseases classified elsewhere (via E85.-), G99.8 — Other specified disorders of nervous system in diseases classified elsewhere (via E85.-), H42 — Glaucoma in diseases classified elsewhere (via E85.-), I43 — Cardiomyopathy in diseases classified elsewhere (via E85.-), I68.0 — Cerebral amyloid angiopathy (via E85.-), I79.8 — Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere (via E85.-), J99 — Respiratory disorders in diseases classified elsewhere (via E85.-), K77 — Liver disorders in diseases classified elsewhere (via E85.-), L99 — Other disorders of skin and subcutaneous tissue in diseases classified elsewhere (via E85.-), M14.8 — Arthropathies in other specified diseases classified elsewhere (via E85.-), N08 — Glomerular disorders in diseases classified elsewhere (via E85.-), N29 — Other disorders of kidney and ureter in diseases classified elsewhere (via E85.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

Clinical classification (AHRQ CCSR):END016 — Other specified and unspecified nutritional and metabolic disorders (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Other specified and unspecified nutritional and metabolic disorders).

E83.823 — ABCC6 deficiency causing generalized arterial calcification of infancy, E83.824 — ABCC6 deficiency causing pseudoxanthoma elasticum, E83.825 — CD73 deficiency causing arterial calcification, E83.89 — Other disorders of mineral metabolism, E83.9 — Disorder of mineral metabolism, unspecified, E85.0 — Non-neuropathic heredofamilial amyloidosis, E85.1 — Neuropathic heredofamilial amyloidosis, E85.2 — Heredofamilial amyloidosis, unspecified, E85.3 — Secondary systemic amyloidosis, E85.4 — Organ-limited amyloidosis, E85.81 — Light chain (AL) amyloidosis, E85.82 — Wild-type transthyretin-related (ATTR) amyloidosis, E85.89 — Other amyloidosis, E85.9 — Amyloidosis, unspecified, E88.01 — Alpha-1-antitrypsin deficiency, E88.02 — Plasminogen deficiency, E88.09 — Other disorders of plasma-protein metabolism, not elsewhere classified, E88.1 — Lipodystrophy, not elsewhere classified, E88.10 — Lipodystrophy, unspecified, E88.11 — Partial lipodystrophy, +258 more

Contextual Map

Every relationship of E85.8 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run E85.8 with these 21 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Excludes2 notes

Referenced by Code First instructions (15)

Clinical classification (CCSR)

Nearest codes (10)

Change history (2)

Common coding questions

Can E85.8 be billed directly?

No. E85.8 (Other amyloidosis) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "E85.8 — Other amyloidosis." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/e85.8-other-amyloidosis

Change history

  • FY2018 — October 1, 2017
    Became a non-billable header
    FY2018 changes
  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Other amyloidosis

Nearest Codes in This Family

Official ICD-10-CM classifications closest to E85.8 in its code family, with their registry titles.

View all codes in the E85 family