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G37.81 ICD-10-CM Code: Myelin oligodendrocyte glycoprotein antibody disease

Compare with another code for G37.81Check this code on a claim

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
1 inclusion term · 3 code-also instructions
Risk adjustment
CMS-HCC V28: 1 category · CMS-HCC V22 category 77

Billable · FY2027A valid, specific ICD-10-CM code, reportable for dates of service in FY2027.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too, and is marked with where it comes from.

Code alsoMay be needed with this code
  • associated manifestations, if known, such as:
  • noninfectious acute disseminated encephalomyelitis (G04.81)
  • neuromyelitis optica (G36.0)
IncludesWhat this code covers
  • MOG antibody disease

Where it sits Source: CMS/NCHS

Under:Chapter 6: Diseases of the Nervous SystemG35-G37 Demyelinating diseases of the central nervous systemG37 Other demyelinating diseases of central nervous systemG37.8 Other specified demyelinating diseases of central nervous system

Most relevant related codes MedCoder-derived

Read off the official notes above and this code’s own position in the tabular list. Which to report is a documentation question; Compare shows the two side by side.

CompareCheck ClaimView Related Codes

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 058 — MULTIPLE SCLEROSIS AND CEREBELLAR ATAXIA WITH MCC (MDC 01)
  • MS-DRG 059 — MULTIPLE SCLEROSIS AND CEREBELLAR ATAXIA WITH CC (MDC 01)
  • MS-DRG 060 — MULTIPLE SCLEROSIS AND CEREBELLAR ATAXIA WITHOUT CC/MCC (MDC 01)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

  • HCC 198 — Multiple Sclerosis

Other models: CMS-HCC V22 HCC 77

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for G37.81 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Inclusion Terms

Alternative terms the tabular list files under this code.

  • MOG antibody disease

Code Also

Additional codes that may be required to fully describe the encounter.

  • associated manifestations, if known, such as:
  • noninfectious acute disseminated encephalomyelitis (G04.81)
  • neuromyelitis optica (G36.0)

Coder workflow for G37.81

MedCoder structured workflow — derived from this code’s own official record

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Official instructions as workflow

  • Code Also — related condition(3 notes)

    Coding workflow: Review the related condition when both are documented and the instruction applies. A Code Also note does not fix sequencing; the order follows the circumstances of the encounter.

    ReviewG04.81, G36.0

    See the official tabular notes · Guidelines I.A.17

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Myelin oligodendrocyte glycoprotein antibody disease is a billable ICD-10-CM diagnosis code (G37.81).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Verify Before Coding

  • CC as a secondary diagnosis (FY2027). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 160 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 3 MS-DRGs: DRG 058 (MDC 01), DRG 059 (MDC 01), DRG 060 (MDC 01).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):NVS020 — Other nervous system disorders (neither hereditary nor degenerative) (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

G35.D — Multiple sclerosis, unspecified, G36.0 — Neuromyelitis optica [Devic], G36.1 — Acute and subacute hemorrhagic leukoencephalitis [Hurst], G36.8 — Other specified acute disseminated demyelination, G36.9 — Acute disseminated demyelination, unspecified, G37.0 — Diffuse sclerosis of central nervous system, G37.1 — Central demyelination of corpus callosum, G37.2 — Central pontine myelinolysis, G37.3 — Acute transverse myelitis in demyelinating disease of central nervous system, G37.5 — Concentric sclerosis [Balo] of central nervous system, G37.89 — Other specified demyelinating diseases of central nervous system, G37.9 — Demyelinating disease of central nervous system, unspecified, G80.0 — Spastic quadriplegic cerebral palsy, G80.1 — Spastic diplegic cerebral palsy, G80.2 — Spastic hemiplegic cerebral palsy, G80.3 — Athetoid cerebral palsy, G80.4 — Ataxic cerebral palsy, G80.8 — Other cerebral palsy, G80.9 — Cerebral palsy, unspecified, G81.00 — Flaccid hemiplegia affecting unspecified side, +139 more

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Multiple Sclerosis) for risk-adjusted payment.

G35 — Multiple sclerosis, G35.A — Relapsing-remitting multiple sclerosis, G35.B0 — Primary progressive multiple sclerosis, unspecified, G35.B1 — Active primary progressive multiple sclerosis, G35.B2 — Non-active primary progressive multiple sclerosis, G35.C0 — Secondary progressive multiple sclerosis, unspecified, G35.C1 — Active secondary progressive multiple sclerosis, G35.C2 — Non-active secondary progressive multiple sclerosis, G35.D — Multiple sclerosis, unspecified, G36.0 — Neuromyelitis optica [Devic], G36.1 — Acute and subacute hemorrhagic leukoencephalitis [Hurst], G36.8 — Other specified acute disseminated demyelination, G36.9 — Acute disseminated demyelination, unspecified, G37.0 — Diffuse sclerosis of central nervous system, G37.1 — Central demyelination of corpus callosum, G37.2 — Central pontine myelinolysis, G37.5 — Concentric sclerosis [Balo] of central nervous system, G37.89 — Other specified demyelinating diseases of central nervous system, G37.9 — Demyelinating disease of central nervous system, unspecified

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Other nervous system disorders (neither hereditary nor degenerative)).

G36.1 — Acute and subacute hemorrhagic leukoencephalitis [Hurst], G36.8 — Other specified acute disseminated demyelination, G36.9 — Acute disseminated demyelination, unspecified, G37.0 — Diffuse sclerosis of central nervous system, G37.1 — Central demyelination of corpus callosum, G37.2 — Central pontine myelinolysis, G37.3 — Acute transverse myelitis in demyelinating disease of central nervous system, G37.4 — Subacute necrotizing myelitis of central nervous system, G37.5 — Concentric sclerosis [Balo] of central nervous system, G37.8 — Other specified demyelinating diseases of central nervous system, G37.89 — Other specified demyelinating diseases of central nervous system, G37.9 — Demyelinating disease of central nervous system, unspecified, G46.0 — Middle cerebral artery syndrome, G46.1 — Anterior cerebral artery syndrome, G46.2 — Posterior cerebral artery syndrome, G46.3 — Brain stem stroke syndrome, G46.4 — Cerebellar stroke syndrome, G46.5 — Pure motor lacunar syndrome, G46.6 — Pure sensory lacunar syndrome, G46.7 — Other lacunar syndromes, +97 more

Contextual Map

Every relationship of G37.81 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run G37.81 with these 2 related codes in Claim Check

Hierarchy

Code Also

Clinical classification (CCSR)

Risk adjustment (CMS-HCC)

  • HCC 198 — Multiple Sclerosis [CMS-HCC]— CMS-HCC V28 · 2026

MS-DRG Grouper

MDC crossing

  • MDC 01 — Diseases and Disorders of the Nervous System[MDC crossing]: “Diseases and Disorders of the Nervous System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 8,919 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Index entries

  • Disease, diseased, MOG antibody[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Disease, diseased, myelin oligodendrocyte glycoprotein antibody[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • MOGAD (myelin oligodendrocyte glycoprotein antibody disease)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027

Nearest codes (10)

Change history

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Indexed Clinical Terms (3)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Risk adjustment Official source data
2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "G37.81 — Myelin oligodendrocyte glycoprotein antibody disease." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/g37.81-myelin-oligodendrocyte-glycoprotein-antibody-disease

Change history

  • FY2024 — October 1, 2023
    Added to the code set
    Myelin oligodendrocyte glycoprotein antibody disease
    FY2024 changes

Nearest Codes in This Family

Official ICD-10-CM classifications closest to G37.81 in its code family, with their registry titles.

View all codes in the G37 family