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G35.B2 ICD-10-CM Code: Non-active primary progressive multiple sclerosis

Compare with another code for G35.B2Check this code on a claim

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Official instructions
1 inclusion term
Risk adjustment
CMS-HCC V28: 1 category · CMS-HCC V22 category 77 · RxHCC V08 category 159

What these terms mean →

Billable · FY2027A valid, specific ICD-10-CM code, reportable for dates of service in FY2027.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too, and is marked with where it comes from.

IncludesWhat this code covers
  • Primary progressive multiple sclerosis without evidence of inflammatory disease activity

Where it sits Source: CMS/NCHS

Under:Chapter 6: Diseases of the Nervous SystemG35-G37 Demyelinating diseases of the central nervous systemG35 Multiple sclerosisG35.B Primary progressive multiple sclerosis

CompareCheck ClaimView Related Codes

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 058 — MULTIPLE SCLEROSIS AND CEREBELLAR ATAXIA WITH MCC (MDC 01)
  • MS-DRG 059 — MULTIPLE SCLEROSIS AND CEREBELLAR ATAXIA WITH CC (MDC 01)
  • MS-DRG 060 — MULTIPLE SCLEROSIS AND CEREBELLAR ATAXIA WITHOUT CC/MCC (MDC 01)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

  • HCC 198 — Multiple Sclerosis

Other models: CMS-HCC V22 HCC 77 · RxHCC V08 HCC 159

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for G35.B2 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Primary progressive multiple sclerosis without evidence of inflammatory disease activity

Don’t confuse G35.B2 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of G35.B2 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • G35.B0— Specificity relationship (Review)

    Overlapping diagnoses in the same category.

    Overlapping codes in the same category — the documentation decides which is the more specific fit.

    What moves you there: A record that documents no more than “Primary progressive multiple sclerosis, unspecified” takes G35.B0; specificity in the record moves it back here.

    Full comparison: G35.B2 vs G35.B0 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Non-active primary progressive multiple sclerosis is a billable ICD-10-CM diagnosis code (G35.B2).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name G35.B2 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 1 Excludes1 note: G37.3 — Acute transverse myelitis in demyelinating disease of central nervous system (via G35.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 1 Excludes2 note: G04 — Encephalitis, myelitis and encephalomyelitis (via G35.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 2 Code First instructions: F02 — Dementia in other diseases classified elsewhere (via G35.-), F48.2 — Pseudobulbar affect (via G35.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 3 MS-DRGs: DRG 058 (MDC 01), DRG 059 (MDC 01), DRG 060 (MDC 01).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):NVS005 — Multiple sclerosis (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Multiple Sclerosis) for risk-adjusted payment.

G35 — Multiple sclerosis, G35.A — Relapsing-remitting multiple sclerosis, G35.B0 — Primary progressive multiple sclerosis, unspecified, G35.B1 — Active primary progressive multiple sclerosis, G35.C0 — Secondary progressive multiple sclerosis, unspecified, G35.C1 — Active secondary progressive multiple sclerosis, G35.C2 — Non-active secondary progressive multiple sclerosis, G35.D — Multiple sclerosis, unspecified, G36.0 — Neuromyelitis optica [Devic], G36.1 — Acute and subacute hemorrhagic leukoencephalitis [Hurst], G36.8 — Other specified acute disseminated demyelination, G36.9 — Acute disseminated demyelination, unspecified, G37.0 — Diffuse sclerosis of central nervous system, G37.1 — Central demyelination of corpus callosum, G37.2 — Central pontine myelinolysis, G37.5 — Concentric sclerosis [Balo] of central nervous system, G37.81 — Myelin oligodendrocyte glycoprotein antibody disease, G37.89 — Other specified demyelinating diseases of central nervous system, G37.9 — Demyelinating disease of central nervous system, unspecified

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Multiple sclerosis).

G35 — Multiple sclerosis, G35.A — Relapsing-remitting multiple sclerosis, G35.B0 — Primary progressive multiple sclerosis, unspecified, G35.B1 — Active primary progressive multiple sclerosis, G35.C0 — Secondary progressive multiple sclerosis, unspecified, G35.C1 — Active secondary progressive multiple sclerosis, G35.C2 — Non-active secondary progressive multiple sclerosis, G35.D — Multiple sclerosis, unspecified

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Sclerosis, sclerotic”; these codes share that main term but sit in a different category of the Tabular List.

A52.11 — Tabes dorsalis (spinal, posterior), E27.8 — Other specified disorders of adrenal gland (adrenal), E31.8 — Other polyglandular dysfunction (polyglandular), E72.09 — Other disorders of amino-acid transport (renal, with, cystine storage disease), E75.23 — Krabbe disease (brain, Krabbe's), G11.11 — Friedreich ataxia (Friedreich's), G11.9 — Hereditary ataxia, unspecified (hereditary, cerebellar), G12.21 — Amyotrophic lateral sclerosis (lateral), G12.23 — Primary lateral sclerosis (primary, lateral), G25.9 — Extrapyramidal and movement disorder, unspecified (extrapyramidal), G37.0 — Diffuse sclerosis of central nervous system (diffuse), G37.5 — Concentric sclerosis [Balo] of central nervous system (concentric), G37.9 — Demyelinating disease of central nervous system, unspecified (brain), G61.0 — Guillain-Barre syndrome (spinal, ascending), G93.81 — Temporal sclerosis (temporal), G95.89 — Other specified diseases of spinal cord (spinal), H35.00 — Unspecified background retinopathy (retina), I05.8 — Other rheumatic mitral valve diseases (mitral), I07.8 — Other rheumatic tricuspid valve diseases (tricuspid), I25.10 — Atherosclerotic heart disease of native coronary artery without angina pectoris (coronary), +29 more

Contextual Map

Every relationship of G35.B2 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run G35.B2 with these 4 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Excludes2 notes

Referenced by Code First instructions

Clinical classification (CCSR)

Risk adjustment (CMS-HCC)

  • HCC 198 — Multiple Sclerosis [CMS-HCC]— CMS-HCC V28 · 2026

MS-DRG Grouper

MDC crossing

  • MDC 01 — Diseases and Disorders of the Nervous System[MDC crossing]: “Diseases and Disorders of the Nervous System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 8,919 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Index entries

  • Sclerosis, sclerotic, multiple (brain stem) (cerebral) (disseminated) (generalized) (spinal cord), progressive, primary, non-active[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Sclerosis, sclerotic, multiple (brain stem) (cerebral) (disseminated) (generalized) (spinal cord), progressive, primary, without evidence of inflammatory disease activity[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027

Nearest codes (10)

Change history

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Indexed Clinical Terms (2)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Risk adjustment Official source data
2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "G35.B2 — Non-active primary progressive multiple sclerosis." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/g35.b2-non-active-primary-progressive-multiple-sclerosis

Change history

  • FY2026 — October 1, 2025
    Added to the code set
    Non-active primary progressive multiple sclerosis
    FY2026 changes

Nearest Codes in This Family

Official ICD-10-CM classifications closest to G35.B2 in its code family, with their registry titles.

View all codes in the G35 family