G61.81 ICD-10-CM Code: Chronic inflammatory demyelinating polyneuritis

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for G61.81 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on G61.81 itself; “inherited from” names the category or block whose note applies here.

Coder workflow for G61.81

MedCoder structured workflow — derived from this code’s own official record

Before you code G61.81

1. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with G61.81. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

   See the official tabular notes

Choose the right path

1. Does the documentation support a condition named in G61.81’s Excludes1 note?
   Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
   No → Continue.

   ReviewM79.2, O26.82, M54.10

Consider G61.81. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement

Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Acuity

Acute or chronic as documented; when both are documented and separate codes exist, both are reported with the acute code first (Guidelines I.B.8).

Official instructions as workflow

• Excludes1 — check before selecting G61.81(4 notes)

  Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with G61.81: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

  CompareM79.2, O26.82, M54.10

  See the official tabular notes · Guidelines I.A.12.a

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Indexed Clinical Terms (5)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

• CIDP (chronic inflammatory demyelinating polyneuropathy )
• Polyneuritis, polyneuritic, demyelinating, chronic inflammatory (CIDP)
• Polyneuritis, polyneuritic, inflammatory, chronic demyelinating (CIDP)
• Polyneuropathy (peripheral), demyelinating, chronic inflammatory (CIDP)
• Polyneuropathy (peripheral), inflammatory, chronic demyelinating (CIDP)

Don’t confuse G61.81 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of G61.81 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

• M79.2— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of neuralgia NOS moves the case to M79.2; the two are not reported together unless documented as unrelated.

  Full comparison: G61.81 vs M79.2 →

• O26.82— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of peripheral neuritis in pregnancy moves the case to O26.82; the two are not reported together unless documented as unrelated.

  Full comparison: G61.81 vs O26.82 →

• M54.10— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of radiculitis NOS moves the case to M54.10; the two are not reported together unless documented as unrelated.

  Full comparison: G61.81 vs M54.10 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Verify Before Coding

• CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 108 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 2 MS-DRGs: DRG 073 (MDC 01), DRG 074 (MDC 01).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):NVS015 — Polyneuropathies (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

G57.83 — Other specified mononeuropathies of bilateral lower limbs, G57.90 — Unspecified mononeuropathy of unspecified lower limb, G57.91 — Unspecified mononeuropathy of right lower limb, G57.92 — Unspecified mononeuropathy of left lower limb, G57.93 — Unspecified mononeuropathy of bilateral lower limbs, G58.0 — Intercostal neuropathy, G58.7 — Mononeuritis multiplex, G58.8 — Other specified mononeuropathies, G58.9 — Mononeuropathy, unspecified, G60.0 — Hereditary motor and sensory neuropathy, G60.1 — Refsum's disease, G60.2 — Neuropathy in association with hereditary ataxia, G60.3 — Idiopathic progressive neuropathy, G60.8 — Other hereditary and idiopathic neuropathies, G60.9 — Hereditary and idiopathic neuropathy, unspecified, G61.82 — Multifocal motor neuropathy, G61.89 — Other inflammatory polyneuropathies, G62.81 — Critical illness polyneuropathy, G62.89 — Other specified polyneuropathies, G64 — Other disorders of peripheral nervous system, +87 more

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Chronic Inflammatory Demyelinating Polyneuritis and Multifocal Motor Neuropathy) for risk-adjusted payment.

G61.82 — Multifocal motor neuropathy

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Polyneuropathies).

E13.42 — Other specified diabetes mellitus with diabetic polyneuropathy, E13.43 — Other specified diabetes mellitus with diabetic autonomic (poly)neuropathy, G60.0 — Hereditary motor and sensory neuropathy, G60.1 — Refsum's disease, G60.2 — Neuropathy in association with hereditary ataxia, G60.3 — Idiopathic progressive neuropathy, G60.8 — Other hereditary and idiopathic neuropathies, G60.9 — Hereditary and idiopathic neuropathy, unspecified, G61.0 — Guillain-Barre syndrome, G61.1 — Serum neuropathy, G61.82 — Multifocal motor neuropathy, G61.89 — Other inflammatory polyneuropathies, G61.9 — Inflammatory polyneuropathy, unspecified, G62.0 — Drug-induced polyneuropathy, G62.1 — Alcoholic polyneuropathy, G62.2 — Polyneuropathy due to other toxic agents, G62.81 — Critical illness polyneuropathy, G62.82 — Radiation-induced polyneuropathy, G62.89 — Other specified polyneuropathies, G62.9 — Polyneuropathy, unspecified, +42 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Polyneuropathy”, “Polyneuritis, polyneuritic”; these codes share that main term but sit in a different category of the Tabular List.

E56.9 — Vitamin deficiency, unspecified (in, avitaminosis NEC), E63.9 — Nutritional deficiency, unspecified (nutritional NEC), E80.20 — Unspecified porphyria (in, porphyria), E85.1 — Neuropathic heredofamilial amyloidosis (amyloid), E88.9 — Metabolic disorder, unspecified (in, metabolic disease NEC), G52.7 — Disorders of multiple cranial nerves (cranialis), G60.1 — Refsum's disease (hereditary ataxic), G60.3 — Idiopathic progressive neuropathy (progressive), G60.8 — Other hereditary and idiopathic neuropathies (sensory), G60.9 — Hereditary and idiopathic neuropathy, unspecified (idiopathic), G62.0 — Drug-induced polyneuropathy (drug-induced), G62.1 — Alcoholic polyneuropathy (alcoholic), G62.2 — Polyneuropathy due to other toxic agents (lead), G62.81 — Critical illness polyneuropathy (critical illness), G62.82 — Radiation-induced polyneuropathy (in, radiation), G62.89 — Other specified polyneuropathies (specified NEC), G62.9 — Polyneuropathy, unspecified, G65.1 — Sequelae of other inflammatory polyneuropathy (inflammatory, sequelae), G65.2 — Sequelae of toxic polyneuropathy (lead, sequelae), M30.0 — Polyarteritis nodosa (in, polyarteritis nodosa), +26 more

Contextual Map

Every relationship of G61.81 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

• G00-G99 — Chapter 6: Diseases of the Nervous System (G00-G99) (G00-G99)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Clinical classification (CCSR)

• NVS015 — Polyneuropathies[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)

Risk adjustment (CMS-HCC)

• HCC 193 — Chronic Inflammatory Demyelinating Polyneuritis and Multifocal Motor Neuropathy [CMS-HCC]— CMS-HCC V28 · 2026

MS-DRG Grouper

• CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”— CMS MS-DRG Definitions Manual (Appendix C) · FY2026
• DRG 073 — CRANIAL AND PERIPHERAL NERVE DISORDERS WITH MCC[MS-DRG]: “CRANIAL AND PERIPHERAL NERVE DISORDERS WITH MCC (MDC 01)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 074 — CRANIAL AND PERIPHERAL NERVE DISORDERS WITHOUT MCC[MS-DRG]: “CRANIAL AND PERIPHERAL NERVE DISORDERS WITHOUT MCC (MDC 01)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026

MDC crossing

• MDC 01 — Diseases and Disorders of the Nervous System[MDC crossing]: “Diseases and Disorders of the Nervous System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 8,892 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

• CIDP (chronic inflammatory demyelinating polyneuropathy )[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Polyneuritis, polyneuritic, demyelinating, chronic inflammatory (CIDP)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Polyneuritis, polyneuritic, inflammatory, chronic demyelinating (CIDP)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Polyneuropathy (peripheral), demyelinating, chronic inflammatory (CIDP)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Polyneuropathy (peripheral), inflammatory, chronic demyelinating (CIDP)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes

• G61 — Inflammatory polyneuropathy[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• G61.0 — Guillain-Barre syndrome[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• G61.1 — Serum neuropathy[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• G61.8 — Other inflammatory polyneuropathies[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• G61.82 — Multifocal motor neuropathy[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• G61.89 — Other inflammatory polyneuropathies[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• G61.9 — Inflammatory polyneuropathy, unspecified[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Change history

• FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data

CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page

Claim edits Official source data

CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page

Inpatient payment groups Official source data

CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page

Risk adjustment Official source data

2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page

Change history and date-of-service validity Official source data

CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page

Comparisons, relationships and the contextual map MedCoder structured relationship

Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears

Summary and FAQ answers MedCoder explanation

Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Nearest Codes in This Family

Official ICD-10-CM classifications closest to G61.81 in its code family, with their registry titles.

• G61 — Inflammatory polyneuropathy
• G61.0 — Guillain-Barre syndrome
• G61.1 — Serum neuropathy
• G61.8 — Other inflammatory polyneuropathies
• G61.82 — Multifocal motor neuropathy
• G61.89 — Other inflammatory polyneuropathies
• G61.9 — Inflammatory polyneuropathy, unspecified

View all codes in the G61 family