I67.3 ICD-10-CM Code: Progressive vascular leukoencephalopathy

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for I67.3 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on I67.3 itself; “inherited from” names the category or block whose note applies here.

Coder workflow for I67.3

MedCoder structured workflow — derived from this code’s own official record

Before you code I67.3

1. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with I67.3. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

   See the official tabular notes

Choose the right path

1. Does the documentation support a condition named in I67.3’s Excludes1 note?
   Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
   No → Continue.

   ReviewI63.2, S06

Consider I67.3. Then work the Use Additional Code note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement

Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

The conditions the Use Additional Code note names

Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.

Official instructions as workflow

• Excludes1 — check before selecting I67.3(3 notes)

  Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with I67.3: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

  CompareI63.2, S06

  See the official tabular notes · Guidelines I.A.12.a

• Excludes2 — not part of I67.3(1 note)

  Coding workflow: The conditions named in this note are not included in I67.3. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

  CompareI69.8

  See the official tabular notes · Guidelines I.A.12.b

• Use Additional Code — after identifying I67.3(8 notes)

  Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with I67.3 when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.

  ReviewF10, Z77.22, Z87.891, Z57.31, F17, Z72.0

  See the official tabular notes · Guidelines I.A.13

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Indexed Clinical Terms (3)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

• Binswanger's disease
• Leukoencephalopathy, Binswanger's
• Leukoencephalopathy, vascular, progressive

Official Coding Guidelines

Official source data — quoted verbatim from the CMS/NCHS Official Guidelines

Official source data — quoted verbatim from the CMS/NCHS Official Guidelines

Verbatim excerpts from the ICD-10-CM Official Guidelines for Coding and Reporting (CMS/NCHS) that govern this code.

Don’t confuse I67.3 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of I67.3 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

• I63.3— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of Occlusion and stenosis of cerebral artery causing cerebral infarction moves the case to I63.3; the two are not reported together unless documented as unrelated.

  Full comparison: I67.3 vs I63.3 →

• I63.5— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of Occlusion and stenosis of cerebral artery causing cerebral infarction moves the case to I63.5; the two are not reported together unless documented as unrelated.

  Full comparison: I67.3 vs I63.5 →

• I63.2— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of Occlusion and stenosis of precerebral artery causing cerebral infarction moves the case to I63.2; the two are not reported together unless documented as unrelated.

  Full comparison: I67.3 vs I63.2 →

• S06— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of traumatic intracranial hemorrhage moves the case to S06; the two are not reported together unless documented as unrelated.

  Full comparison: I67.3 vs S06 →

• I67.9— Specificity relationship (Review)

  Overlapping diagnoses in the same category.

  Overlapping codes in the same category — the documentation decides which is the more specific fit.

  What moves you there: A record that documents no more than “Cerebrovascular disease, unspecified” takes I67.9; specificity in the record moves it back here.

  Full comparison: I67.3 vs I67.9 →

• I69.8— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of sequelae of the listed conditions adds I69.8; it is not part of this code and both may be reported when both are documented.

  Full comparison: I67.3 vs I69.8 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Decision Points

The directives on this code's own record, as a pre-claim checklist.

1. 8 Use Additional Code instructions — report the named additional code(s) when the documentation supports them. See the Use Additional Code notes
2. 3 Excludes1 entries — codes named there are generally not reported together with this code (Guidelines I.A.12.a). See the Excludes1 notes
3. 1 Excludes2 entry — those conditions are not part of this code and may be reported additionally when documented. See the Excludes2 notes

Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.

Verify Before Coding

• CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name I67.3 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 1 Excludes1 note: G31.84 — Mild cognitive impairment of uncertain or unknown etiology (via I67.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 2 Excludes2 notes: I10 — Essential (primary) hypertension (via I67.-), I15 — Secondary hypertension (via I67.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 1 Code First instruction: G46 — Vascular syndromes of brain in cerebrovascular diseases (via I67.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 175 clinically related codes on its CMS exclusion list. Does not count toward severity when the stay groups to DRGs 974-976 (HIV with Major Related Condition).

Named in the grouper logic of 5 MS-DRGs: DRG 056 (MDC 01), DRG 057 (MDC 01), DRG 974 (MDC 25), DRG 975 (MDC 25), DRG 976 (MDC 25).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):CIR024 — Other and ill-defined cerebrovascular disease (default); NVS020 — Other nervous system disorders (neither hereditary nor degenerative).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

G04.00 — Acute disseminated encephalitis and encephalomyelitis, unspecified, G04.01 — Postinfectious acute disseminated encephalitis and encephalomyelitis (postinfectious ADEM), G04.31 — Postinfectious acute necrotizing hemorrhagic encephalopathy, G04.81 — Other encephalitis and encephalomyelitis, G04.89 — Other myelitis, G04.90 — Encephalitis and encephalomyelitis, unspecified, G04.91 — Myelitis, unspecified, G37.0 — Diffuse sclerosis of central nervous system, G37.4 — Subacute necrotizing myelitis of central nervous system, G37.5 — Concentric sclerosis [Balo] of central nervous system, J09.X3 — Influenza due to identified novel influenza A virus with gastrointestinal manifestations, J09.X9 — Influenza due to identified novel influenza A virus with other manifestations, J10.2 — Influenza due to other identified influenza virus with gastrointestinal manifestations, J10.81 — Influenza due to other identified influenza virus with encephalopathy, J10.82 — Influenza due to other identified influenza virus with myocarditis, J10.83 — Influenza due to other identified influenza virus with otitis media, J10.89 — Influenza due to other identified influenza virus with other manifestations, J11.2 — Influenza due to unidentified influenza virus with gastrointestinal manifestations, J11.81 — Influenza due to unidentified influenza virus with encephalopathy, J11.82 — Influenza due to unidentified influenza virus with myocarditis, +154 more

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Dementia, Mild or Unspecified) for risk-adjusted payment.

F03.A3 — Unspecified dementia, mild, with mood disturbance, F03.A4 — Unspecified dementia, mild, with anxiety, G30.0 — Alzheimer's disease with early onset, G30.1 — Alzheimer's disease with late onset, G30.8 — Other Alzheimer's disease, G30.9 — Alzheimer's disease, unspecified, G31.01 — Pick's disease, G31.09 — Other frontotemporal neurocognitive disorder, G31.81 — Alpers disease, G31.82 — Leigh's disease, G31.83 — Neurocognitive disorder with Lewy bodies, G31.86 — Alexander disease, G91.0 — Communicating hydrocephalus, G91.1 — Obstructive hydrocephalus, G91.2 — (Idiopathic) normal pressure hydrocephalus, G91.3 — Post-traumatic hydrocephalus, unspecified, G91.4 — Hydrocephalus in diseases classified elsewhere, G91.8 — Other hydrocephalus, G91.9 — Hydrocephalus, unspecified, G93.7 — Reye's syndrome, +44 more

Related risk categories

These categories interact through CMS's HCC hierarchy — one can suppress the other's risk-adjustment weight when both are present on a claim.

Dementia, Severe, Dementia, Moderate

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical categories (Other and ill-defined cerebrovascular disease, Other nervous system disorders (neither hereditary nor degenerative)).

G96.810 — Intracranial hypotension, unspecified, G96.811 — Intracranial hypotension, spontaneous, G96.819 — Other intracranial hypotension, G96.89 — Other specified disorders of central nervous system, G96.9 — Disorder of central nervous system, unspecified, G98.0 — Neurogenic arthritis, not elsewhere classified, G98.8 — Other disorders of nervous system, G99.8 — Other specified disorders of nervous system in diseases classified elsewhere, I67.1 — Cerebral aneurysm, nonruptured, I67.2 — Cerebral atherosclerosis, I67.4 — Hypertensive encephalopathy, I67.5 — Moyamoya disease, I67.6 — Nonpyogenic thrombosis of intracranial venous system, I67.7 — Cerebral arteritis, not elsewhere classified, I67.81 — Acute cerebrovascular insufficiency, I67.82 — Cerebral ischemia, I67.83 — Posterior reversible encephalopathy syndrome, I67.841 — Reversible cerebrovascular vasoconstriction syndrome, I67.848 — Other cerebrovascular vasospasm and vasoconstriction, I67.850 — Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, +116 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Leukoencephalopathy”; these codes share that main term but sit in a different category of the Tabular List.

A81.1 — Subacute sclerosing panencephalitis (van Bogaert's), A81.2 — Progressive multifocal leukoencephalopathy (multifocal), E75.25 — Metachromatic leukodystrophy (metachromatic), E88.43 — Disorders of mitochondrial tRNA synthetases (with, thalamus - brainstem involvement - high lactate), G04.02 — Postimmunization acute disseminated encephalitis, myelitis and encephalomyelitis (postimmunization and postvaccinal), G92.8 — Other toxic encephalopathy (heroin vapor), G93.42 — Megalencephalic leukoencephalopathy with subcortical cysts (megalencephalic, with subcortical cysts), G93.43 — Leukoencephalopathy with calcifications and cysts (with, calcifications and cysts), G93.44 — Adult-onset leukodystrophy with axonal spheroids (adult-onset, with axonal spheroids), G93.49 — Other encephalopathy, G93.6 — Cerebral edema (reversible, posterior)

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

HIV Screening Test

Contextual Map

Every relationship of I67.3 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run I67.3 with these 4 related codes in Claim Check

Hierarchy

• I00-I99 — Chapter 9: Diseases of the Circulatory System (I00-I99) (I00-I99)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I60-I69 — Cerebrovascular diseases[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Referenced by Excludes1 notes

• G31.84 — Mild cognitive impairment of uncertain or unknown etiology[Excludes1](via I67.-): “cerebrovascular diseases (I60-I69)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Excludes2 notes

• I10 — Essential (primary) hypertension[Excludes2](via I67.-): “essential (primary) hypertension involving vessels of brain (I60-I69)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• I15 — Secondary hypertension[Excludes2](via I67.-): “secondary hypertension involving vessels of brain (I60-I69)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Code First instructions

• G46 — Vascular syndromes of brain in cerebrovascular diseases[Code First](via I67.-): “underlying cerebrovascular disease (I60-I69)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Clinical classification (CCSR)

• CIR024 — Other and ill-defined cerebrovascular disease[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)
• NVS020 — Other nervous system disorders (neither hereditary nor degenerative)[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)

Risk adjustment (CMS-HCC)

• HCC 127 — Dementia, Mild or Unspecified [CMS-HCC]— CMS-HCC V28 · 2026

MS-DRG Grouper

• CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC). Not counted when the stay groups to DRGs 974-976 (HIV with Major Related Condition).”— CMS MS-DRG Definitions Manual (Appendix C) · FY2026
• DRG 056 — DEGENERATIVE NERVOUS SYSTEM DISORDERS WITH MCC[MS-DRG]: “DEGENERATIVE NERVOUS SYSTEM DISORDERS WITH MCC (MDC 01)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 057 — DEGENERATIVE NERVOUS SYSTEM DISORDERS WITHOUT MCC[MS-DRG]: “DEGENERATIVE NERVOUS SYSTEM DISORDERS WITHOUT MCC (MDC 01)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 974 — HIV WITH MAJOR RELATED CONDITION WITH MCC[MS-DRG]: “HIV WITH MAJOR RELATED CONDITION WITH MCC (MDC 25)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 975 — HIV WITH MAJOR RELATED CONDITION WITH CC[MS-DRG]: “HIV WITH MAJOR RELATED CONDITION WITH CC (MDC 25)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 976 — HIV WITH MAJOR RELATED CONDITION WITHOUT CC/MCC[MS-DRG]: “HIV WITH MAJOR RELATED CONDITION WITHOUT CC/MCC (MDC 25)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026

MDC crossing

• MDC 01 — Diseases and Disorders of the Nervous System[MDC crossing]: “Diseases and Disorders of the Nervous System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 8,892 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026
• MDC 25 — Human Immunodeficiency Virus Infections[MDC crossing]: “Human Immunodeficiency Virus Infections — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

• Binswanger's disease[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Leukoencephalopathy, Binswanger's[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Leukoencephalopathy, vascular, progressive[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (20)

• I67 — Other cerebrovascular diseases[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I67.0 — Dissection of cerebral arteries, nonruptured[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I67.1 — Cerebral aneurysm, nonruptured[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I67.2 — Cerebral atherosclerosis[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I67.4 — Hypertensive encephalopathy[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I67.5 — Moyamoya disease[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I67.6 — Nonpyogenic thrombosis of intracranial venous system[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• I67.7 — Cerebral arteritis, not elsewhere classified[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• and 12 more

Change history

• FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data

CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page

Coding guidelines Official source data

ICD-10-CM Official Guidelines for Coding and Reporting (FY2026), quoted by section Release, file and checksum · Publisher’s page

Claim edits Official source data

CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page

Inpatient payment groups Official source data

CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page

Risk adjustment Official source data

2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page

Change history and date-of-service validity Official source data

CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page

Comparisons, relationships and the contextual map MedCoder structured relationship

Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears

Summary and FAQ answers MedCoder explanation

Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Nearest Codes in This Family

Official ICD-10-CM classifications closest to I67.3 in its code family, with their registry titles.

• I67 — Other cerebrovascular diseases
• I67.0 — Dissection of cerebral arteries, nonruptured
• I67.1 — Cerebral aneurysm, nonruptured
• I67.2 — Cerebral atherosclerosis
• I67.4 — Hypertensive encephalopathy
• I67.5 — Moyamoya disease
• I67.6 — Nonpyogenic thrombosis of intracranial venous system
• I67.7 — Cerebral arteritis, not elsewhere classified
• I67.8 — Other specified cerebrovascular diseases
• I67.81 — Acute cerebrovascular insufficiency

View all codes in the I67 family