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N25.1 ICD-10-CM Code: Nephrogenic diabetes insipidus

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
1 Excludes1 · 1 Excludes2
Risk adjustment
CMS-HCC V22 category 23 · RxHCC V08 category 43

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 698 — OTHER KIDNEY AND URINARY TRACT DIAGNOSES WITH MCC (MDC 11)
  • MS-DRG 699 — OTHER KIDNEY AND URINARY TRACT DIAGNOSES WITH CC (MDC 11)
  • MS-DRG 700 — OTHER KIDNEY AND URINARY TRACT DIAGNOSES WITHOUT CC/MCC (MDC 11)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for N25.1 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Notes without a marker are published on N25.1 itself; “inherited from” names the category or block whose note applies here.

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Source: inherited from N25-N29

Coder workflow for N25.1

MedCoder structured workflow — derived from this code’s own official record

Before you code N25.1

  1. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with N25.1. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support a condition named in N25.1’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewE23.2

Consider N25.1. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Official instructions as workflow

  • Excludes1 — check before selecting N25.1(1 note)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with N25.1: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareE23.2

    See the official tabular notes · Guidelines I.A.12.a

  • Excludes2 — not part of N25.1(1 note)

    Coding workflow: The conditions named in this note are not included in N25.1. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    See the official tabular notes · Guidelines I.A.12.b

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition N25.1 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewE23.2

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Don’t confuse N25.1 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of N25.1 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • E23.2— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of diabetes insipidus NOS moves the case to E23.2; the two are not reported together unless documented as unrelated.

    Full comparison: N25.1 vs E23.2 →

  • N25.9— Specificity relationship (Review)

    Overlapping diagnoses in the same category.

    Overlapping codes in the same category — the documentation decides which is the more specific fit.

    What moves you there: A record that documents no more than “Disorder resulting from impaired renal tubular function, unspecified” takes N25.9; specificity in the record moves it back here.

    Full comparison: N25.1 vs N25.9 →

  • N20— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of disorders of kidney and ureter with urolithiasis adds N20; it is not part of this code and both may be reported when both are documented.

    Full comparison: N25.1 vs N20 →

  • N23— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of disorders of kidney and ureter with urolithiasis adds N23; it is not part of this code and both may be reported when both are documented.

    Full comparison: N25.1 vs N23 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Code Overview

Nephrogenic diabetes insipidus is a billable ICD-10-CM diagnosis code (N25.1).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (2)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Verify Before Coding

  • CC as a secondary diagnosis (FY2027). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name N25.1 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 1 Excludes1 note: E23.2 — Diabetes insipidus.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 273 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 3 MS-DRGs: DRG 698 (MDC 11), DRG 699 (MDC 11), DRG 700 (MDC 11).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):GEN006 — Other specified and unspecified diseases of kidney and ureters (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

N17.1 — Acute kidney failure with acute cortical necrosis, N17.2 — Acute kidney failure with medullary necrosis, N17.8 — Other acute kidney failure, N17.9 — Acute kidney failure, unspecified, N18.32 — Chronic kidney disease, stage 3b, N18.4 — Chronic kidney disease, stage 4 (severe), N18.5 — Chronic kidney disease, stage 5, N18.6 — End stage renal disease, N19 — Unspecified kidney failure, N25.0 — Renal osteodystrophy, N25.81 — Secondary hyperparathyroidism of renal origin, N25.89 — Other disorders resulting from impaired renal tubular function, N25.9 — Disorder resulting from impaired renal tubular function, unspecified, N26.1 — Atrophy of kidney (terminal), N26.9 — Renal sclerosis, unspecified, N27.0 — Small kidney, unilateral, N27.1 — Small kidney, bilateral, N27.9 — Small kidney, unspecified, N28.1 — Cyst of kidney, acquired, N28.81 — Hypertrophy of kidney, +252 more

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Other specified and unspecified diseases of kidney and ureters).

N13.1 — Hydronephrosis with ureteral stricture, not elsewhere classified, N13.2 — Hydronephrosis with renal and ureteral calculous obstruction, N13.30 — Unspecified hydronephrosis, N13.39 — Other hydronephrosis, N13.4 — Hydroureter, N13.5 — Crossing vessel and stricture of ureter without hydronephrosis, N13.8 — Other obstructive and reflux uropathy, N13.9 — Obstructive and reflux uropathy, unspecified, N23 — Unspecified renal colic, N25.0 — Renal osteodystrophy, N25.81 — Secondary hyperparathyroidism of renal origin, N25.89 — Other disorders resulting from impaired renal tubular function, N25.9 — Disorder resulting from impaired renal tubular function, unspecified, N26.1 — Atrophy of kidney (terminal), N26.2 — Page kidney, N27.0 — Small kidney, unilateral, N27.1 — Small kidney, bilateral, N27.9 — Small kidney, unspecified, N28.0 — Ischemia and infarction of kidney, N28.1 — Cyst of kidney, acquired, +16 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Diabetes, diabetic”; these codes share that main term but sit in a different category of the Tabular List.

E13.638 — Other specified diabetes mellitus with other oral complications (specified type NEC, with, oral complication NEC), E13.641 — Other specified diabetes mellitus with hypoglycemia with coma (specified type NEC, with, hypoglycemia, with coma), E13.649 — Other specified diabetes mellitus with hypoglycemia without coma (specified type NEC, with, hypoglycemia), E13.65 — Other specified diabetes mellitus with hyperglycemia (specified type NEC, with, hyperglycemia), E13.69 — Other specified diabetes mellitus with other specified complication (specified type NEC, with, complication, specified NEC), E13.8 — Other specified diabetes mellitus with unspecified complications (specified type NEC, with, complication), E13.9 — Other specified diabetes mellitus without complications (hepatogenous), E23.2 — Diabetes insipidus (insipidus), E83.110 — Hereditary hemochromatosis (bronzed), E83.39 — Other disorders of phosphorus metabolism (phosphate), O24.410 — Gestational diabetes mellitus in pregnancy, diet controlled (gestational, diet controlled), O24.414 — Gestational diabetes mellitus in pregnancy, insulin controlled (gestational, insulincontrolled), O24.415 — Gestational diabetes mellitus in pregnancy, controlled by oral hypoglycemic drugs (gestational, oral drug controlled), O24.419 — Gestational diabetes mellitus in pregnancy, unspecified control (gestational), O24.420 — Gestational diabetes mellitus in childbirth, diet controlled (gestational, in childbirth, diet controlled), O24.424 — Gestational diabetes mellitus in childbirth, insulin controlled (gestational, in childbirth, insulincontrolled), O24.425 — Gestational diabetes mellitus in childbirth, controlled by oral hypoglycemic drugs (gestational, in childbirth, oral drug controlled), O24.429 — Gestational diabetes mellitus in childbirth, unspecified control (gestational, in childbirth), O24.430 — Gestational diabetes mellitus in the puerperium, diet controlled (gestational, puerperal, diet controlled), O24.434 — Gestational diabetes mellitus in the puerperium, insulin controlled (gestational, puerperal, insulincontrolled), +238 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Gamma-glutamyl Transferase (GGT) Test, Lipid Panel

Contextual Map

Every relationship of N25.1 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run N25.1 with this related code in Claim Check

Hierarchy

Excludes1

  • E23.2 — Diabetes insipidus[Excludes1]: “diabetes insipidus NOS (E23.2)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Excludes1 notes

  • E23.2 — Diabetes insipidus[Excludes1]: “nephrogenic diabetes insipidus (N25.1)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 11 — Diseases and Disorders of the Kidney and Urinary Tract[MDC crossing]: “Diseases and Disorders of the Kidney and Urinary Tract — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 3,578 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Index entries

  • Diabetes, diabetic (mellitus) (sugar), insipidus, nephrogenic[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Diabetes, diabetic (mellitus) (sugar), insipidus, vasopressin resistant[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "N25.1 — Nephrogenic diabetes insipidus." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/n25.1-nephrogenic-diabetes-insipidus

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Nephrogenic diabetes insipidus

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to N25.1 in its code family, with their registry titles.

View all codes in the N25 family