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P25.0 ICD-10-CM Code: Interstitial emphysema originating in the perinatal period

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Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Billable · FY2027A valid, specific ICD-10-CM code, reportable for dates of service in FY2027.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too, and is marked with where it comes from.

The tabular list publishes no instructional note for this code itself.

Where it sits Source: CMS/NCHS

Under:Chapter 16: Certain Conditions Originating in the Perinatal PeriodP19-P29 Respiratory and cardiovascular disorders specific to the perinatal periodP25 Interstitial emphysema and related conditions originating in the perinatal period

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Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 791 — PREMATURITY WITH MAJOR PROBLEMS (MDC 15)
  • MS-DRG 793 — FULL TERM NEONATE WITH MAJOR PROBLEMS (MDC 15)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Interstitial emphysema originating in the perinatal period is a billable ICD-10-CM diagnosis code (P25.0).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Verify Before Coding

  • MCC as a secondary diagnosis (FY2027). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name P25.0 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 2 Excludes1 notes: J43 — Emphysema, J98.2 — Interstitial emphysema.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: MCC — Major Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 78 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 2 MS-DRGs: DRG 791 (MDC 15), DRG 793 (MDC 15).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):PNL006 — Respiratory perinatal condition (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as MCC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

P24.01 — Meconium aspiration with respiratory symptoms, P24.10 — Neonatal aspiration of (clear) amniotic fluid and mucus without respiratory symptoms, P24.11 — Neonatal aspiration of (clear) amniotic fluid and mucus with respiratory symptoms, P24.20 — Neonatal aspiration of blood without respiratory symptoms, P24.21 — Neonatal aspiration of blood with respiratory symptoms, P24.30 — Neonatal aspiration of milk and regurgitated food without respiratory symptoms, P24.31 — Neonatal aspiration of milk and regurgitated food with respiratory symptoms, P24.80 — Other neonatal aspiration without respiratory symptoms, P24.81 — Other neonatal aspiration with respiratory symptoms, P24.9 — Neonatal aspiration, unspecified, P25.1 — Pneumothorax originating in the perinatal period, P25.2 — Pneumomediastinum originating in the perinatal period, P25.3 — Pneumopericardium originating in the perinatal period, P25.8 — Other conditions related to interstitial emphysema originating in the perinatal period, P26.0 — Tracheobronchial hemorrhage originating in the perinatal period, P26.1 — Massive pulmonary hemorrhage originating in the perinatal period, P26.8 — Other pulmonary hemorrhages originating in the perinatal period, P26.9 — Unspecified pulmonary hemorrhage originating in the perinatal period, P27.0 — Wilson-Mikity syndrome, P27.1 — Bronchopulmonary dysplasia originating in the perinatal period, +57 more

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Respiratory perinatal condition).

P24.01 — Meconium aspiration with respiratory symptoms, P24.10 — Neonatal aspiration of (clear) amniotic fluid and mucus without respiratory symptoms, P24.11 — Neonatal aspiration of (clear) amniotic fluid and mucus with respiratory symptoms, P24.20 — Neonatal aspiration of blood without respiratory symptoms, P24.21 — Neonatal aspiration of blood with respiratory symptoms, P24.30 — Neonatal aspiration of milk and regurgitated food without respiratory symptoms, P24.31 — Neonatal aspiration of milk and regurgitated food with respiratory symptoms, P24.80 — Other neonatal aspiration without respiratory symptoms, P24.81 — Other neonatal aspiration with respiratory symptoms, P24.9 — Neonatal aspiration, unspecified, P25.1 — Pneumothorax originating in the perinatal period, P25.2 — Pneumomediastinum originating in the perinatal period, P25.3 — Pneumopericardium originating in the perinatal period, P25.8 — Other conditions related to interstitial emphysema originating in the perinatal period, P26.0 — Tracheobronchial hemorrhage originating in the perinatal period, P26.1 — Massive pulmonary hemorrhage originating in the perinatal period, P26.8 — Other pulmonary hemorrhages originating in the perinatal period, P26.9 — Unspecified pulmonary hemorrhage originating in the perinatal period, P27.0 — Wilson-Mikity syndrome, P27.1 — Bronchopulmonary dysplasia originating in the perinatal period, +33 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Emphysema”; these codes share that main term but sit in a different category of the Tabular List.

E32.8 — Other diseases of thymus (thymus), H11.89 — Other specified disorders of conjunctiva (conjunctiva), J43.0 — Unilateral pulmonary emphysema [MacLeod's syndrome] (unilateral), J43.1 — Panlobular emphysema (panacinar), J43.2 — Centrilobular emphysema (centrilobular), J43.8 — Other emphysema (specified NEC), J43.9 — Emphysema, unspecified, J98.2 — Interstitial emphysema (mediastinal), J98.3 — Compensatory emphysema (compensatory), T79.7 — Traumatic subcutaneous emphysema (traumatic), T81.82 — Emphysema (subcutaneous) resulting from a procedure (surgical)

Contextual Map

Every relationship of P25.0 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run P25.0 with these 2 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

  • J43 — Emphysema[Excludes1]: “neonatal interstitial emphysema (P25.0)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2027
  • J98.2 — Interstitial emphysema[Excludes1]: “emphysema in newborn (P25.0)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2027

Clinical classification (CCSR)

MS-DRG Grouper

  • MCC — Major Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (MCC).”— CMS MS-DRG Definitions Manual (Appendix C) · FY2027
  • DRG 791 — PREMATURITY WITH MAJOR PROBLEMS[MS-DRG]: “PREMATURITY WITH MAJOR PROBLEMS (MDC 15)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
  • DRG 793 — FULL TERM NEONATE WITH MAJOR PROBLEMS[MS-DRG]: “FULL TERM NEONATE WITH MAJOR PROBLEMS (MDC 15)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027

MDC crossing

Index entries

  • Emphysema (atrophic) (bullous) (chronic) (interlobular) (lung) (obstructive) (pulmonary) (senile) (vesicular), congenital (interstitial)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Emphysema (atrophic) (bullous) (chronic) (interlobular) (lung) (obstructive) (pulmonary) (senile) (vesicular), interstitial, congenital[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Emphysema (atrophic) (bullous) (chronic) (interlobular) (lung) (obstructive) (pulmonary) (senile) (vesicular), interstitial, perinatal period[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027

Nearest codes

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Indexed Clinical Terms (3)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "P25.0 — Interstitial emphysema originating in the perinatal period." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/p25.0-interstitial-emphysema-originating-in-the-perinatal-period

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Interstitial emphysema originating in the perinatal period

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to P25.0 in its code family, with their registry titles.

View all codes in the P25 family