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ICD-10/T80.51XD

T80.51XD ICD-10-CM Code: Anaphylactic reaction due to administration of blood and blood products, subsequent encounter

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0, Appendix B.

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Official Registry Overview & Definition

Anaphylactic reaction due to administration of blood and blood products, subsequent encounter is a billable ICD-10-CM diagnosis code (T80.51D).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for T80.51XD in the official ICD-10-CM tabular list.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • complications following perfusion

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • Use additional code(s) to identify the specified condition resulting from the complication
  • Use additional code to identify devices involved and details of circumstances (Y62-Y82)

Change history

No changes recorded for this code — unchanged since the FY2016 baseline of the change ledger.

Verify Before Coding

  • Billable — reportable as written.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Referenced by Other Codes

Clinical classification (AHRQ CCSR):INJ072 — Complication of other surgical or medical care, injury, subsequent encounter (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Potential MS-DRG Relationships (FY2026)

Not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity.

Named in the grouper logic of 2 MS-DRGs: DRG 949 (MDC 23), DRG 950 (MDC 23).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Official ICD-10-CM tabular notes on other codes that name T80.51XD or its code family.

6 Excludes1 notes across 2 chapters: R57 (via T80.5.-), T78.2 (via T80.5.-), T79.4 (via T80.5.-), T81.1 (via T80.5.-), T88.6 (via T80.5.-), T88.7 (via T80.-).

6 Excludes2 notes: T45.8 (via T80.-), T78 (via T80.-), T79 (via T80.-), T81 (via T80.-), T88 (via T80.-), T88.1 (via T80.5.-).

Frequently Asked Questions (FAQ) & Clinical Guidance

Does T80.51XD require a 7th character?

Yes. The appropriate 7th character is to be added to each code from category T80.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to T80.51XD in its code family, with their registry titles.

  • T80.49XD — Other Rh incompatibility reaction due to transfusion of blood or blood products, subsequent encounter
  • T80.49XS — Other Rh incompatibility reaction due to transfusion of blood or blood products, sequela
  • T80.5 — Anaphylactic reaction due to serum
  • T80.51 — Anaphylactic reaction due to administration of blood and blood products
  • T80.51XA — Anaphylactic reaction due to administration of blood and blood products, initial encounter
  • T80.51XS — Anaphylactic reaction due to administration of blood and blood products, sequela
  • T80.52 — Anaphylactic reaction due to vaccination
  • T80.52XA — Anaphylactic reaction due to vaccination, initial encounter
  • T80.52XD — Anaphylactic reaction due to vaccination, subsequent encounter
  • T80.52XS — Anaphylactic reaction due to vaccination, sequela

View all codes in the T80 family