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T80.59XS ICD-10-CM Code: Anaphylactic reaction due to other serum, sequela

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0, Appendix B.

  • MS-DRG 922 — OTHER INJURY, POISONING AND TOXIC EFFECT DIAGNOSES WITH MCC (MDC 21)
  • MS-DRG 923 — OTHER INJURY, POISONING AND TOXIC EFFECT DIAGNOSES WITHOUT MCC (MDC 21)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Official Registry Overview & Definition

Anaphylactic reaction due to other serum, sequela is a billable ICD-10-CM diagnosis code (T80.59S).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for T80.59XS in the official ICD-10-CM tabular list.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • complications following perfusion

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • Use additional code(s) to identify the specified condition resulting from the complication
  • Use additional code to identify devices involved and details of circumstances (Y62-Y82)

Frequently Compared Codes

The official Excludes notes on T80.59XS name these codes. Each comparison page covers when the two can — or must not — be reported together.

Change history

No changes recorded for this code — unchanged since the FY2016 baseline of the change ledger.

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Contextual Map

Every relationship of T80.59XS in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

  • S00-T88 — Chapter 19: Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88) (S00-T88) [Hierarchy]
  • T80-T88 — Complications of surgical and medical care, not elsewhere classified [Hierarchy]

Referenced by Excludes1 notes

  • R57 — Shock, not elsewhere classified [Excludes1](via T80.5.-): “anaphylactic shock due to serum (T80.5-)” · check together
  • T78.2 — Anaphylactic shock, unspecified [Excludes1](via T80.5.-): “anaphylactic reaction or shock due to serum (T80.5-)” · check together
  • T79.4 — Traumatic shock [Excludes1](via T80.5.-): “anaphylactic shock due to serum (T80.5-)” · check together
  • T81.1 — Postprocedural shock [Excludes1](via T80.5.-): “anaphylactic shock due to serum (T80.5-)” · check together
  • T88.6 — Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered [Excludes1](via T80.5.-): “anaphylactic reaction due to serum (T80.5-)” · check together
  • T88.7 — Unspecified adverse effect of drug or medicament [Excludes1](via T80.-): “specified adverse effects of drugs and medicaments (A00-R94 and T80-T88.6, T88.8)” · check together

Referenced by Excludes2 notes

  • T45.8 — Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents [Excludes2](via T80.-): “transfusion reactions (T80.-)” · check together
  • T78 — Adverse effects, not elsewhere classified [Excludes2](via T80.-): “complications of surgical and medical care NEC (T80-T88)” · check together
  • T79 — Certain early complications of trauma, not elsewhere classified [Excludes2](via T80.-): “complications occurring during or following medical procedures (T80-T88)” · check together
  • T81 — Complications of procedures, not elsewhere classified [Excludes2](via T80.-): “complications following infusion, transfusion and therapeutic injection (T80.-)” · check together
  • T88 — Other complications of surgical and medical care, not elsewhere classified [Excludes2](via T80.-): “complication following infusion, transfusion and therapeutic injection (T80.-)” · check together
  • T88.1 — Other complications following immunization, not elsewhere classified [Excludes2](via T80.5.-): “anaphylactic shock due to serum (T80.5-)” · check together

Clinical classification (CCSR)

  • INJ076 — Complication, sequela [CCSR]

Potential MS-DRG

  • DRG 922 — OTHER INJURY, POISONING AND TOXIC EFFECT DIAGNOSES WITH MCC [MS-DRG]: “OTHER INJURY, POISONING AND TOXIC EFFECT DIAGNOSES WITH MCC (MDC 21)”
  • DRG 923 — OTHER INJURY, POISONING AND TOXIC EFFECT DIAGNOSES WITHOUT MCC [MS-DRG]: “OTHER INJURY, POISONING AND TOXIC EFFECT DIAGNOSES WITHOUT MCC (MDC 21)”

MDC crossing · procedures (32029)

  • MDC 21 — Injuries, Poisonings and Toxic Effects of Drugs [MDC crossing]: “Injuries, Poisonings and Toxic Effects of Drugs — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”
  • 0016070 — Bypass Cerebral Ventricle to Nasopharynx with Autologous Tissue Substitute, Open Approach [Same-MDC procedure]: “Bypass Cerebral Ventricle to Nasopharynx with Autologous Tissue Substitute, Open Approach — grouped in MDC 21, the procedure side of this code's crossing.” · check together
  • 0016071 — Bypass Cerebral Ventricle to Mastoid Sinus with Autologous Tissue Substitute, Open Approach [Same-MDC procedure]: “Bypass Cerebral Ventricle to Mastoid Sinus with Autologous Tissue Substitute, Open Approach — grouped in MDC 21, the procedure side of this code's crossing.” · check together
  • 0016072 — Bypass Cerebral Ventricle to Atrium with Autologous Tissue Substitute, Open Approach [Same-MDC procedure]: “Bypass Cerebral Ventricle to Atrium with Autologous Tissue Substitute, Open Approach — grouped in MDC 21, the procedure side of this code's crossing.” · check together
  • 0016073 — Bypass Cerebral Ventricle to Blood Vessel with Autologous Tissue Substitute, Open Approach [Same-MDC procedure]: “Bypass Cerebral Ventricle to Blood Vessel with Autologous Tissue Substitute, Open Approach — grouped in MDC 21, the procedure side of this code's crossing.” · check together
  • 0016074 — Bypass Cerebral Ventricle to Pleural Cavity with Autologous Tissue Substitute, Open Approach [Same-MDC procedure]: “Bypass Cerebral Ventricle to Pleural Cavity with Autologous Tissue Substitute, Open Approach — grouped in MDC 21, the procedure side of this code's crossing.” · check together
  • and 32024 more

Nearest codes (40)

  • T80 — Complications following infusion, transfusion and therapeutic injection [Sibling]
  • T80.419 — Rh incompatibility with hemolytic transfusion reaction, unspecified [Sibling]
  • T80.419A — Rh incompatibility with hemolytic transfusion reaction, unspecified, initial encounter [Sibling]
  • T80.419D — Rh incompatibility with hemolytic transfusion reaction, unspecified, subsequent encounter [Sibling]
  • T80.419S — Rh incompatibility with hemolytic transfusion reaction, unspecified, sequela [Sibling]
  • T80.49 — Other Rh incompatibility reaction due to transfusion of blood or blood products [Sibling]
  • T80.49XA — Other Rh incompatibility reaction due to transfusion of blood or blood products, initial encounter [Sibling]
  • T80.49XD — Other Rh incompatibility reaction due to transfusion of blood or blood products, subsequent encounter [Sibling]
  • and 32 more

Referenced by Other Codes

Clinical classification (AHRQ CCSR):INJ076 — Complication, sequela (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Potential MS-DRG Relationships (FY2026)

Not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity.

Named in the grouper logic of 2 MS-DRGs: DRG 922 (MDC 21), DRG 923 (MDC 21).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Official ICD-10-CM tabular notes on other codes that name T80.59XS or its code family.

6 Excludes1 notes across 2 chapters: R57 (via T80.5.-), T78.2 (via T80.5.-), T79.4 (via T80.5.-), T81.1 (via T80.5.-), T88.6 (via T80.5.-), T88.7 (via T80.-).

6 Excludes2 notes: T45.8 (via T80.-), T78 (via T80.-), T79 (via T80.-), T81 (via T80.-), T88 (via T80.-), T88.1 (via T80.5.-).

Frequently Asked Questions (FAQ) & Clinical Guidance

Does T80.59XS require a 7th character?

Yes. The appropriate 7th character is to be added to each code from category T80.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to T80.59XS in its code family, with their registry titles.

  • T80.52XD — Anaphylactic reaction due to vaccination, subsequent encounter
  • T80.52XS — Anaphylactic reaction due to vaccination, sequela
  • T80.59 — Anaphylactic reaction due to other serum
  • T80.59XA — Anaphylactic reaction due to other serum, initial encounter
  • T80.59XD — Anaphylactic reaction due to other serum, subsequent encounter
  • T80.6 — Other serum reactions
  • T80.61 — Other serum reaction due to administration of blood and blood products
  • T80.61XA — Other serum reaction due to administration of blood and blood products, initial encounter
  • T80.61XD — Other serum reaction due to administration of blood and blood products, subsequent encounter
  • T80.61XS — Other serum reaction due to administration of blood and blood products, sequela

View all codes in the T80 family