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T80.82 ICD-10-CM Code: Complication of immune effector cellular therapy

Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.

Official Registry Overview & Definition

Complication of immune effector cellular therapy is a non-billable ICD-10-CM category code (T80.82). A more specific billable subcode must be selected for claims submission.

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for T80.82 in the official ICD-10-CM tabular list.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • complications following perfusion

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Complication of chimeric antigen receptor (CAR-T) cell therapy
  • Complication of IEC therapy

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code to identify the specific complication, such as:
  • cytokine release syndrome (D89.83-)
  • immune effector cell-associated neurotoxicity syndrome (G92.0-)
  • Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • Use additional code(s) to identify the specified condition resulting from the complication
  • Use additional code to identify devices involved and details of circumstances (Y62-Y82)

Indexed Clinical Terms (3)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Complication (s) (from) (of), chimeric antigen receptorcell therapy (CAR-T)
  • Complication (s) (from) (of), IECtherapy (immune effector cellular)
  • Complication (s) (from) (of), immune effector cellulartherapy (IEC)

Frequently Compared Codes

The official Excludes notes on T80.82 name these codes. Each comparison page covers when the two can — or must not — be reported together.

Change history

  • FY2022 — 2021-10-01
    Added to the code set
    Complication of immune effector cellular therapy
    FY2022 changes

Verify Before Coding

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Relationships & Classification

Official ICD-10-CM tabular notes on other codes that name T80.82 or its code family.

1 Excludes1 notes: T88.7 (via T80.-).

5 Excludes2 notes: T45.8 (via T80.-), T78 (via T80.-), T79 (via T80.-), T81 (via T80.-), T88 (via T80.-).

1 Code First instructions: G92.0.

Contextual Map

Every relationship of T80.82 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

  • S00-T88 — Chapter 19: Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88) (S00-T88) [Hierarchy]

Excludes2

  • T45.AX5 — Adverse effect of immune checkpoint inhibitors and immunostimulant drugs [Excludes2]: “adverse effect of immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)” · check together
  • T86.0 — Complications of bone marrow transplant [Excludes2]: “complication of bone marrow transplant (T86.0)” · check together
  • T86.5 — Complications of stem cell transplant [Excludes2]: “complication of stem cell transplant (T86.5)” · check together

Use Additional Code

  • D89.83 — Cytokine release syndrome [Use Additional Code]: “cytokine release syndrome (D89.83-)” · check together
  • G92.0 — Immune effector cell-associated neurotoxicity syndrome [Use Additional Code]: “immune effector cell-associated neurotoxicity syndrome (G92.0-)” · check together

Referenced by Excludes1 notes

  • T88.7 — Unspecified adverse effect of drug or medicament [Excludes1](via T80.-): “specified adverse effects of drugs and medicaments (A00-R94 and T80-T88.6, T88.8)” · check together

Referenced by Excludes2 notes

  • T45.8 — Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents [Excludes2](via T80.-): “transfusion reactions (T80.-)” · check together
  • T78 — Adverse effects, not elsewhere classified [Excludes2](via T80.-): “complications of surgical and medical care NEC (T80-T88)” · check together
  • T79 — Certain early complications of trauma, not elsewhere classified [Excludes2](via T80.-): “complications occurring during or following medical procedures (T80-T88)” · check together
  • T81 — Complications of procedures, not elsewhere classified [Excludes2](via T80.-): “complications following infusion, transfusion and therapeutic injection (T80.-)” · check together
  • T88 — Other complications of surgical and medical care, not elsewhere classified [Excludes2](via T80.-): “complication following infusion, transfusion and therapeutic injection (T80.-)” · check together

Referenced by Code First instructions

  • G92.0 — Immune effector cell-associated neurotoxicity syndrome [Code First]: “complications of immune effector cellular therapy (T80.82)” · check together

Index entries

  • Complication (s) (from) (of), chimeric antigen receptorcell therapy (CAR-T)[Index term]
  • Complication (s) (from) (of), IECtherapy (immune effector cellular)[Index term]
  • Complication (s) (from) (of), immune effector cellulartherapy (IEC)[Index term]

Nearest codes (40)

  • T80 — Complications following infusion, transfusion and therapeutic injection [Sibling]
  • T80.61XD — Other serum reaction due to administration of blood and blood products, subsequent encounter [Sibling]
  • T80.61XS — Other serum reaction due to administration of blood and blood products, sequela [Sibling]
  • T80.62 — Other serum reaction due to vaccination [Sibling]
  • T80.62XA — Other serum reaction due to vaccination, initial encounter [Sibling]
  • T80.62XD — Other serum reaction due to vaccination, subsequent encounter [Sibling]
  • T80.62XS — Other serum reaction due to vaccination, sequela [Sibling]
  • T80.69 — Other serum reaction due to other serum [Sibling]
  • and 32 more

Change history

  • FY2022 — Added to the code set [Change history]

Frequently Asked Questions (FAQ) & Clinical Guidance

Can T80.82 be billed directly?

No. T80.82 (Complication of immune effector cellular therapy) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.

Does T80.82 require a 7th character?

Yes. The appropriate 7th character is to be added to each code from category T80.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to T80.82 in its code family, with their registry titles.

  • T80.810S — Extravasation of vesicant antineoplastic chemotherapy, sequela
  • T80.818 — Extravasation of other vesicant agent
  • T80.818A — Extravasation of other vesicant agent, initial encounter
  • T80.818D — Extravasation of other vesicant agent, subsequent encounter
  • T80.818S — Extravasation of other vesicant agent, sequela
  • T80.82XA — Complication of immune effector cellular therapy, initial encounter
  • T80.82XD — Complication of immune effector cellular therapy, subsequent encounter
  • T80.82XS — Complication of immune effector cellular therapy, sequela
  • T80.89 — Other complications following infusion, transfusion and therapeutic injection
  • T80.89XA — Other complications following infusion, transfusion and therapeutic injection, initial encounter

View all codes in the T80 family