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T80.82XA ICD-10-CM Code: Complication of immune effector cellular therapy, initial encounter

Compare with another codeCheck this code on a claim

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

7th character
Required — see the character table on this page
Tabular directives
3 inclusion terms · 31 Excludes2 · 6 use-additional codes

Billable · FY2027A valid, specific ICD-10-CM code, reportable for dates of service in FY2027.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too; the Instructions section marks which is which.

Use additional codeReport with this code when documented
  • code to identify the specific complication, such as:
  • cytokine release syndrome (D89.83-)
  • immune effector cell-associated neurotoxicity syndrome (G92.0-)
  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

+2 more in Instructions

Excludes2Not included here; may be reported together
  • adverse effect of immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
  • complication of bone marrow transplant (T86.0)
  • complication of stem cell transplant (T86.5)
  • bone marrow transplant rejection (T86.01)

+27 more in Instructions

IncludesWhat this code covers
  • complications following perfusion
  • Complication of chimeric antigen receptor (CAR-T) cell therapy
  • Complication of IEC therapy

Most relevant related codes MedCoder-derived

Read off the official notes above and this code’s own position in the tabular list. Which to report is a documentation question; Compare shows the two side by side.

CompareCheck ClaimView Related Codes

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 791 — PREMATURITY WITH MAJOR PROBLEMS (MDC 15)
  • MS-DRG 793 — FULL TERM NEONATE WITH MAJOR PROBLEMS (MDC 15)
  • MS-DRG 814 — RETICULOENDOTHELIAL AND IMMUNITY DISORDERS WITH MCC (MDC 16)
  • MS-DRG 815 — RETICULOENDOTHELIAL AND IMMUNITY DISORDERS WITH CC (MDC 16)
  • MS-DRG 816 — RETICULOENDOTHELIAL AND IMMUNITY DISORDERS WITHOUT CC/MCC (MDC 16)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for T80.82XA in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Notes without a marker are published on T80.82XA itself; “inherited from” names the category or block whose note applies here.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • complications following perfusion

Source: inherited from T80

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Complication of chimeric antigen receptor (CAR-T) cell therapy
  • Complication of IEC therapy

Source: inherited from T80.82

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code to identify the specific complication, such as:
  • cytokine release syndrome (D89.83-) inherited from T80.82
  • immune effector cell-associated neurotoxicity syndrome (G92.0-) inherited from T80.82
  • Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5) inherited from T80-T88
  • Use additional code(s) to identify the specified condition resulting from the complication inherited from T80-T88
  • Use additional code to identify devices involved and details of circumstances (Y62-Y82) inherited from T80-T88

7th Character Guide

"The appropriate 7th character is to be added to each code from category T80"

  • A — initial encounter (this page’s code)
  • D — subsequent encounter
  • S — sequela

How the encounter character is assigned. “Initial encounter” means the patient is receiving active treatment for the condition — it is not limited to the first visit, and a different or new provider giving active treatment still assigns it. “Subsequent encounter” covers care during the healing or recovery phase after active treatment. “Sequela” is for complications or conditions that arise as a direct result of the original condition.

ICD-10-CM Official Guidelines for Coding and Reporting, Section I.C.19.a (paraphrased by MedCoder).

Variant codes in this family

T80.82XA, T80.82XD, T80.82XS

Character meanings are CMS's official 7th-character extensions for this family, as carried in each variant code's official description; variant codes are registry rows. The explanation of how the encounter character is assigned is MedCoder editorial, distinct from the official content above it.

Coder workflow for T80.82XA

MedCoder structured workflow — derived from this code’s own official record

Before you code T80.82XA

  1. A 7th character is required in this family. Confirm the documented encounter: initial (active treatment), subsequent (healing or recovery phase), or sequela. This page’s code carries “A”. “Initial” means active treatment, not the first visit (Guidelines I.C.19.a).

    See the 7th Character Guide · Guide: 7th characters: initial, subsequent, sequela →

Choose the right path

  1. Is the encounter phase documented — active treatment, healing or recovery, or a sequela?
    Yes → Assign the matching 7th character; the variant codes are in the 7th Character Guide.
    No → The code is invalid without its 7th character — query for the missing element.

Consider T80.82XA. Then work the Use Additional Code note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
Encounter type
Active treatment, healing or recovery phase, or sequela — the basis of the 7th character (Guidelines I.C.19.a).
The conditions the Use Additional Code note names
Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.

Official instructions as workflow

  • Excludes2 — not part of T80.82XA(31 notes)

    Coding workflow: The conditions named in this note are not included in T80.82XA. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    CompareT45.AX5, T86.0, T86.5, T86.01, R50.84, E87.71

    See the official tabular notes · Guidelines I.A.12.b

  • Use Additional Code — after identifying T80.82XA(6 notes)

    Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with T80.82XA when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.

    ReviewD89.83, G92.0

    See the official tabular notes · Guidelines I.A.13

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: The patient returns during the healing or recovery phase after active treatment of the same condition.

Coding question: Which 7th character applies?

Path: Review the official 7th-character definitions for this family in the 7th Character Guide.

Reason: “Initial encounter” means active treatment, not the first visit; care during recovery takes “subsequent encounter”, and a complication arising from the original condition takes “sequela” (Guidelines I.C.19.a).

Documentation: A condition the Use Additional Code note names is documented.

Coding question: Is a second code reported with T80.82XA?

Path: Review the Use Additional Code note and the code it names.

Reason: The additional code is reported when the record documents the condition; a conditional instruction applies only when its condition is met (Guidelines I.A.13).

ReviewD89.83, G92.0

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Don’t confuse T80.82XA with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of T80.82XA — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • T80.82XD— Encounter relationship (Review)

    Same underlying diagnosis, different encounter phase.

    The same diagnosis at a different phase of care; one encounter takes one 7th character.

    What moves you there: Documentation of a subsequent encounter moves the case to T80.82XD.

    Full comparison: T80.82XA vs T80.82XD →

  • T80.82XS— Encounter relationship (Review)

    Same underlying diagnosis, different encounter phase.

    The same diagnosis at a different phase of care; one encounter takes one 7th character.

    What moves you there: Documentation of a sequela moves the case to T80.82XS.

    Full comparison: T80.82XA vs T80.82XS →

  • T45.AX5— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of adverse effect of immune checkpoint inhibitors and immunostimulant drugs adds T45.AX5; it is not part of this code and both may be reported when both are documented.

    Full comparison: T80.82XA vs T45.AX5 →

  • T86.0— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of complication of bone marrow transplant adds T86.0; it is not part of this code and both may be reported when both are documented.

    Full comparison: T80.82XA vs T86.0 →

  • T86.5— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of complication of stem cell transplant adds T86.5; it is not part of this code and both may be reported when both are documented.

    Full comparison: T80.82XA vs T86.5 →

  • T86.01— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of bone marrow transplant rejection adds T86.01; it is not part of this code and both may be reported when both are documented.

    Full comparison: T80.82XA vs T86.01 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Complication of immune effector cellular therapy, initial encounter is a billable ICD-10-CM diagnosis code (T80.82XA).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Decision Points

The directives on this code's own record, as a pre-claim checklist.

  1. A 7th character applies in this family. Confirm the documented encounter matches the character assigned. See the official 7th-character definitions and this code’s variants
  2. 6 Use Additional Code instructions — report the named additional code(s) when the documentation supports them. See the Use Additional Code notes
  3. 31 Excludes2 entries — those conditions are not part of this code and may be reported additionally when documented. See the Excludes2 notes

Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name T80.82XA or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 1 Excludes1 note: T88.7 — Unspecified adverse effect of drug or medicament (via T80.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 5 Excludes2 notes: T45.8 — Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents (via T80.-), T78 — Adverse effects, not elsewhere classified (via T80.-), T79 — Certain early complications of trauma, not elsewhere classified (via T80.-), T81 — Complications of procedures, not elsewhere classified (via T80.-), T88 — Other complications of surgical and medical care, not elsewhere classified (via T80.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 5 MS-DRGs: DRG 791 (MDC 15), DRG 793 (MDC 15), DRG 814 (MDC 16), DRG 815 (MDC 16), DRG 816 (MDC 16).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):INJ037 — Complication of other surgical or medical care, injury, initial encounter (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same injury, other encounter phase

Same injury, coded at a different phase of treatment via the 7th character.

T80.82XD — Complication of immune effector cellular therapy, subsequent encounterCompare T80.82XA vs T80.82XD →, T80.82XS — Complication of immune effector cellular therapy, sequelaCompare T80.82XA vs T80.82XS →

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Complication of other surgical or medical care, injury, initial encounter).

T80.419A — Rh incompatibility with hemolytic transfusion reaction, unspecified, initial encounter, T80.49XA — Other Rh incompatibility reaction due to transfusion of blood or blood products, initial encounter, T80.51XA — Anaphylactic reaction due to administration of blood and blood products, initial encounter, T80.52XA — Anaphylactic reaction due to vaccination, initial encounter, T80.59XA — Anaphylactic reaction due to other serum, initial encounter, T80.61XA — Other serum reaction due to administration of blood and blood products, initial encounter, T80.62XA — Other serum reaction due to vaccination, initial encounter, T80.69XA — Other serum reaction due to other serum, initial encounter, T80.810A — Extravasation of vesicant antineoplastic chemotherapy, initial encounter, T80.818A — Extravasation of other vesicant agent, initial encounter, T80.89XA — Other complications following infusion, transfusion and therapeutic injection, initial encounter, T80.90XA — Unspecified complication following infusion and therapeutic injection, initial encounter, T80.910A — Acute hemolytic transfusion reaction, unspecified incompatibility, initial encounter, T80.911A — Delayed hemolytic transfusion reaction, unspecified incompatibility, initial encounter, T80.919A — Hemolytic transfusion reaction, unspecified incompatibility, unspecified as acute or delayed, initial encounter, T80.92XA — Unspecified transfusion reaction, initial encounter, T80.A0XA — Non-ABO incompatibility reaction due to transfusion of blood or blood products, unspecified, initial encounter, T80.A10A — Non-ABO incompatibility with acute hemolytic transfusion reaction, initial encounter, T80.A11A — Non-ABO incompatibility with delayed hemolytic transfusion reaction, initial encounter, T80.A19A — Non-ABO incompatibility with hemolytic transfusion reaction, unspecified, initial encounter, +230 more

Contextual Map

Every relationship of T80.82XA in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run T80.82XA with these 6 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Excludes2 notes

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

Nearest codes (40)

Change history

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Common coding questions

MedCoder editorial

Does T80.82XA require a 7th character?

Yes. The appropriate 7th character is to be added to each code from category T80.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 20, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "T80.82XA — Complication of immune effector cellular therapy, initial encounter." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/t80.82xa-complication-of-immune-effector-cellular-therapy-initial-encounter

Change history

  • FY2022 — October 1, 2021
    Added to the code set
    Complication of immune effector cellular therapy, initial encounter
    FY2022 changes

Nearest Codes in This Family

Official ICD-10-CM classifications closest to T80.82XA in its code family, with their registry titles.

View all codes in the T80 family