T80.61XA ICD-10-CM Code: Other serum reaction due to administration of blood and blood products, initial encounter

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for T80.61XA in the official ICD-10-CM tabular list, quoted as published.

Notes without a marker are published on T80.61XA itself; “inherited from” names the category or block whose note applies here.

7th Character Guide

"The appropriate 7th character is to be added to each code from category T80"

• A — initial encounter (this page’s code)
• D — subsequent encounter
• S — sequela

How the encounter character is assigned. “Initial encounter” means the patient is receiving active treatment for the condition — it is not limited to the first visit, and a different or new provider giving active treatment still assigns it. “Subsequent encounter” covers care during the healing or recovery phase after active treatment. “Sequela” is for complications or conditions that arise as a direct result of the original condition.

ICD-10-CM Official Guidelines for Coding and Reporting, Section I.C.19.a (paraphrased by MedCoder).

Variant codes in this family

T80.61XA, T80.61XD, T80.61XS

Character meanings are CMS's official 7th-character extensions for this family, as carried in each variant code's official description; variant codes are registry rows. The explanation of how the encounter character is assigned is MedCoder editorial, distinct from the official content above it.

Coder workflow for T80.61XA

MedCoder structured workflow — derived from this code’s own official record

Before you code T80.61XA

1. “Other” (NEC) means the condition is specified in the record but no dedicated code captures it. Confirm the documented form is not one a sibling code names before settling on T80.61XA; if the record states no specifics at all, the unspecified sibling applies instead. “Other” codes are for documented conditions the classification gives no specific code; “unspecified” codes are for records lacking the detail (Guidelines I.A.9.a, I.A.9.b).

   See the relationships section · Guide: Other vs unspecified (NEC vs NOS) →

2. A 7th character is required in this family. Confirm the documented encounter: initial (active treatment), subsequent (healing or recovery phase), or sequela. This page’s code carries “A”. “Initial” means active treatment, not the first visit (Guidelines I.C.19.a).

   See the 7th Character Guide · Guide: 7th characters: initial, subsequent, sequela →

3. T80.61XA’s title joins a condition with an associated condition or complication. Confirm each component is documented. Where the classification presumes the link through the “with” convention, only a provider statement that the conditions are unrelated defeats it. A combination code is assigned only when it fully identifies the documented conditions; a required second code for the stage, type or manifestation is still reported when the notes ask for it (Guidelines I.B.9, I.A.15).

   Guide: Combination codes →

Choose the right path

1. Is the encounter phase documented — active treatment, healing or recovery, or a sequela?
   Yes → Assign the matching 7th character; the variant codes are in the 7th Character Guide.
   No → The code is invalid without its 7th character — query for the missing element.

Consider T80.61XA. Then work the Use Additional Code note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement

Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Encounter type

Active treatment, healing or recovery phase, or sequela — the basis of the 7th character (Guidelines I.C.19.a).

The associated condition or complication

Whether the associated condition the title names is documented; the “with” convention presumes some links, and a provider statement that the conditions are unrelated defeats it (Guidelines I.A.15).

The conditions the Use Additional Code note names

Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.

Any detail beyond this code’s title

What the record states that a more specific sibling code would capture — or its absence, which itself supports the unspecified code.

Official instructions as workflow

• Excludes2 — not part of T80.61XA(29 notes)

  Coding workflow: The conditions named in this note are not included in T80.61XA. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

  CompareT86.01, R50.84, E87.71, D69.51, E83.111, J95.84

  See the official tabular notes · Guidelines I.A.12.b

• Use Additional Code — after identifying T80.61XA(3 notes)

  Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with T80.61XA when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.

  See the official tabular notes · Guidelines I.A.13

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Don’t confuse T80.61XA with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of T80.61XA — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

• T80.61XD— Encounter relationship (Review)

  Same underlying diagnosis, different encounter phase.

  The same diagnosis at a different phase of care; one encounter takes one 7th character.

  What moves you there: Documentation of a subsequent encounter moves the case to T80.61XD.

  Full comparison: T80.61XA vs T80.61XD →

• T80.61XS— Encounter relationship (Review)

  Same underlying diagnosis, different encounter phase.

  The same diagnosis at a different phase of care; one encounter takes one 7th character.

  What moves you there: Documentation of a sequela moves the case to T80.61XS.

  Full comparison: T80.61XA vs T80.61XS →

• B16— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of serum hepatitis adds B16; it is not part of this code and both may be reported when both are documented.

  Full comparison: T80.61XA vs B16 →

• B19— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of serum hepatitis adds B19; it is not part of this code and both may be reported when both are documented.

  Full comparison: T80.61XA vs B19 →

• T86.01— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of bone marrow transplant rejection adds T86.01; it is not part of this code and both may be reported when both are documented.

  Full comparison: T80.61XA vs T86.01 →

• R50.84— Excludes2 relationship (Informational)

  Distinct conditions — both may be reported.

  A distinct condition — both may be reported when both are documented.

  What moves you there: Documentation of febrile nonhemolytic transfusion reaction adds R50.84; it is not part of this code and both may be reported when both are documented.

  Full comparison: T80.61XA vs R50.84 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Decision Points

The directives on this code's own record, as a pre-claim checklist.

1. A 7th character applies in this family. Confirm the documented encounter matches the character assigned. See the official 7th-character definitions and this code’s variants
2. 3 Use Additional Code instructions — report the named additional code(s) when the documentation supports them. See the Use Additional Code notes
3. 29 Excludes2 entries — those conditions are not part of this code and may be reported additionally when documented. See the Excludes2 notes

Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.

Verify Before Coding

• CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name T80.61XA or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 5 Excludes1 notes across 2 chapters: L50 — Urticaria (via T80.6.-), L95 — Vasculitis limited to skin, not elsewhere classified (via T80.6.-), T78.3 — Angioneurotic edema (via T80.6.-), T80.5 — Anaphylactic reaction due to serum (via T80.6.-), T88.7 — Unspecified adverse effect of drug or medicament (via T80.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 6 Excludes2 notes: T45.8 — Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents (via T80.-), T78 — Adverse effects, not elsewhere classified (via T80.-), T79 — Certain early complications of trauma, not elsewhere classified (via T80.-), T81 — Complications of procedures, not elsewhere classified (via T80.-), T88 — Other complications of surgical and medical care, not elsewhere classified (via T80.-), T88.1 — Other complications following immunization, not elsewhere classified (via T80.6.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 1 Code First instruction: M36.4 — Arthropathy in hypersensitivity reactions classified elsewhere (via T80.6.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 6 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 4 MS-DRGs: DRG 791 (MDC 15), DRG 793 (MDC 15), DRG 915 (MDC 21), DRG 916 (MDC 21).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):INJ037 — Complication of other surgical or medical care, injury, initial encounter (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

T80.51XA — Anaphylactic reaction due to administration of blood and blood products, initial encounter, T80.52XA — Anaphylactic reaction due to vaccination, initial encounter, T80.59XA — Anaphylactic reaction due to other serum, initial encounter, T80.62XA — Other serum reaction due to vaccination, initial encounter, T80.69XA — Other serum reaction due to other serum, initial encounter

Same injury, other encounter phase

Same injury, coded at a different phase of treatment via the 7th character.

T80.61XD — Other serum reaction due to administration of blood and blood products, subsequent encounterCompare T80.61XA vs T80.61XD →, T80.61XS — Other serum reaction due to administration of blood and blood products, sequelaCompare T80.61XA vs T80.61XS →

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Complication of other surgical or medical care, injury, initial encounter).

T80.319A — ABO incompatibility with hemolytic transfusion reaction, unspecified, initial encounter, T80.39XA — Other ABO incompatibility reaction due to transfusion of blood or blood products, initial encounter, T80.40XA — Rh incompatibility reaction due to transfusion of blood or blood products, unspecified, initial encounter, T80.410A — Rh incompatibility with acute hemolytic transfusion reaction, initial encounter, T80.411A — Rh incompatibility with delayed hemolytic transfusion reaction, initial encounter, T80.419A — Rh incompatibility with hemolytic transfusion reaction, unspecified, initial encounter, T80.49XA — Other Rh incompatibility reaction due to transfusion of blood or blood products, initial encounter, T80.51XA — Anaphylactic reaction due to administration of blood and blood products, initial encounter, T80.52XA — Anaphylactic reaction due to vaccination, initial encounter, T80.59XA — Anaphylactic reaction due to other serum, initial encounter, T80.62XA — Other serum reaction due to vaccination, initial encounter, T80.69XA — Other serum reaction due to other serum, initial encounter, T80.810A — Extravasation of vesicant antineoplastic chemotherapy, initial encounter, T80.818A — Extravasation of other vesicant agent, initial encounter, T80.82XA — Complication of immune effector cellular therapy, initial encounter, T80.89XA — Other complications following infusion, transfusion and therapeutic injection, initial encounter, T80.90XA — Unspecified complication following infusion and therapeutic injection, initial encounter, T80.910A — Acute hemolytic transfusion reaction, unspecified incompatibility, initial encounter, T80.911A — Delayed hemolytic transfusion reaction, unspecified incompatibility, initial encounter, T80.919A — Hemolytic transfusion reaction, unspecified incompatibility, unspecified as acute or delayed, initial encounter, +230 more

Contextual Map

Every relationship of T80.61XA in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run T80.61XA with these 12 related codes in Claim Check

Hierarchy

• S00-T88 — Chapter 19: Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88) (S00-T88)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T80-T88 — Complications of surgical and medical care, not elsewhere classified[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Referenced by Excludes1 notes

• L50 — Urticaria[Excludes1](via T80.6.-): “serum urticaria (T80.6-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• L95 — Vasculitis limited to skin, not elsewhere classified[Excludes1](via T80.6.-): “serum sickness (T80.6-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T78.3 — Angioneurotic edema[Excludes1](via T80.6.-): “serum urticaria (T80.6-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T80.5 — Anaphylactic reaction due to serum[Excludes1](via T80.6.-): “other serum reaction (T80.6-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T88.7 — Unspecified adverse effect of drug or medicament[Excludes1](via T80.-): “specified adverse effects of drugs and medicaments (A00-R94 and T80-T88.6, T88.8)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Excludes2 notes

• T45.8 — Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents[Excludes2](via T80.-): “transfusion reactions (T80.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T78 — Adverse effects, not elsewhere classified[Excludes2](via T80.-): “complications of surgical and medical care NEC (T80-T88)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T79 — Certain early complications of trauma, not elsewhere classified[Excludes2](via T80.-): “complications occurring during or following medical procedures (T80-T88)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T81 — Complications of procedures, not elsewhere classified[Excludes2](via T80.-): “complications following infusion, transfusion and therapeutic injection (T80.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T88 — Other complications of surgical and medical care, not elsewhere classified[Excludes2](via T80.-): “complication following infusion, transfusion and therapeutic injection (T80.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
• T88.1 — Other complications following immunization, not elsewhere classified[Excludes2](via T80.6.-): “other serum reactions (T80.6-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Code First instructions

• M36.4 — Arthropathy in hypersensitivity reactions classified elsewhere[Code First](via T80.6.-): “serum sickness (T80.6-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Clinical classification (CCSR)

• INJ037 — Complication of other surgical or medical care, injury, initial encounter[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)

MS-DRG Grouper

• CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”— CMS MS-DRG Definitions Manual (Appendix C) · FY2026
• DRG 791 — PREMATURITY WITH MAJOR PROBLEMS[MS-DRG]: “PREMATURITY WITH MAJOR PROBLEMS (MDC 15)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 793 — FULL TERM NEONATE WITH MAJOR PROBLEMS[MS-DRG]: “FULL TERM NEONATE WITH MAJOR PROBLEMS (MDC 15)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 915 — ALLERGIC REACTIONS WITH MCC[MS-DRG]: “ALLERGIC REACTIONS WITH MCC (MDC 21)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 916 — ALLERGIC REACTIONS WITHOUT MCC[MS-DRG]: “ALLERGIC REACTIONS WITHOUT MCC (MDC 21)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026

MDC crossing

• MDC 15 — Newborns and Other Neonates with Conditions Originating in Perinatal Period[MDC crossing]: “Newborns and Other Neonates with Conditions Originating in Perinatal Period — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”— CMS MS-DRG Definitions Manual · FY2026
• MDC 21 — Injuries, Poisonings and Toxic Effects of Drugs[MDC crossing]: “Injuries, Poisonings and Toxic Effects of Drugs — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 32,029 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Nearest codes (40)

• T80 — Complications following infusion, transfusion and therapeutic injection[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T80.419S — Rh incompatibility with hemolytic transfusion reaction, unspecified, sequela[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T80.49 — Other Rh incompatibility reaction due to transfusion of blood or blood products[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T80.49XA — Other Rh incompatibility reaction due to transfusion of blood or blood products, initial encounter[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T80.49XD — Other Rh incompatibility reaction due to transfusion of blood or blood products, subsequent encounter[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T80.49XS — Other Rh incompatibility reaction due to transfusion of blood or blood products, sequela[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T80.5 — Anaphylactic reaction due to serum[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• T80.51 — Anaphylactic reaction due to administration of blood and blood products[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• and 32 more

Change history

• FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Common coding questions

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data

CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page

Claim edits Official source data

CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page

Inpatient payment groups Official source data

CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page

Change history and date-of-service validity Official source data

CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page

Comparisons, relationships and the contextual map MedCoder structured relationship

Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears

Summary and FAQ answers MedCoder explanation

Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Nearest Codes in This Family

Official ICD-10-CM classifications closest to T80.61XA in its code family, with their registry titles.

• T80.59XA — Anaphylactic reaction due to other serum, initial encounter
• T80.59XD — Anaphylactic reaction due to other serum, subsequent encounter
• T80.59XS — Anaphylactic reaction due to other serum, sequela
• T80.6 — Other serum reactions
• T80.61 — Other serum reaction due to administration of blood and blood products
• T80.61XD — Other serum reaction due to administration of blood and blood products, subsequent encounter
• T80.61XS — Other serum reaction due to administration of blood and blood products, sequela
• T80.62 — Other serum reaction due to vaccination
• T80.62XA — Other serum reaction due to vaccination, initial encounter
• T80.62XD — Other serum reaction due to vaccination, subsequent encounter

View all codes in the T80 family