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T80.61 ICD-10-CM Code: Other serum reaction due to administration of blood and blood products

Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.

Coding at a Glance

7th character
Required — see the character table on this page
Tabular directives
1 inclusion term · 29 Excludes2 · 3 use-additional codes

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for T80.61 in the official ICD-10-CM tabular list, quoted as published.

Notes without a marker are published on T80.61 itself; “inherited from” names the category or block whose note applies here.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • complications following perfusion

Source: inherited from T80

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • Use additional code(s) to identify the specified condition resulting from the complication
  • Use additional code to identify devices involved and details of circumstances (Y62-Y82)

Source: inherited from T80-T88

7th Character Guide

"The appropriate 7th character is to be added to each code from category T80"

  • A — initial encounter
  • D — subsequent encounter
  • S — sequela

How the encounter character is assigned. “Initial encounter” means the patient is receiving active treatment for the condition — it is not limited to the first visit, and a different or new provider giving active treatment still assigns it. “Subsequent encounter” covers care during the healing or recovery phase after active treatment. “Sequela” is for complications or conditions that arise as a direct result of the original condition.

ICD-10-CM Official Guidelines for Coding and Reporting, Section I.C.19.a (paraphrased by MedCoder).

Variant codes in this family

T80.61XA, T80.61XD, T80.61XS

Character meanings are CMS's official 7th-character extensions for this family, as carried in each variant code's official description; variant codes are registry rows. The explanation of how the encounter character is assigned is MedCoder editorial, distinct from the official content above it.

Coder workflow for T80.61

MedCoder structured workflow — derived from this code’s own official record

Before you code T80.61

  1. T80.61 is not reportable as written. Select the more specific code beneath it that the documentation supports. Codes are reported to the highest level of specificity the classification provides (Guidelines I.B.2).

    ReviewT80.61XA, T80.61XD, T80.61XS

    See the relationships section · Guide: How to choose an ICD-10-CM code →

  2. “Other” (NEC) means the condition is specified in the record but no dedicated code captures it. Confirm the documented form is not one a sibling code names before settling on T80.61; if the record states no specifics at all, the unspecified sibling applies instead. “Other” codes are for documented conditions the classification gives no specific code; “unspecified” codes are for records lacking the detail (Guidelines I.A.9.a, I.A.9.b).

    See the relationships section · Guide: Other vs unspecified (NEC vs NOS) →

  3. A 7th character is required in this family. Confirm the documented encounter: initial (active treatment), subsequent (healing or recovery phase), or sequela. T80.61 is not valid without one. “Initial” means active treatment, not the first visit (Guidelines I.C.19.a).

    See the 7th Character Guide · Guide: 7th characters: initial, subsequent, sequela →

  4. T80.61’s title joins a condition with an associated condition or complication. Confirm each component is documented. Where the classification presumes the link through the “with” convention, only a provider statement that the conditions are unrelated defeats it. A combination code is assigned only when it fully identifies the documented conditions; a required second code for the stage, type or manifestation is still reported when the notes ask for it (Guidelines I.B.9, I.A.15).

    Guide: Combination codes →

Choose the right path

  1. Does the documentation support one of the more specific codes beneath T80.61?
    Yes → Select that code and continue the checks below on its own page.
    No → T80.61 cannot be reported as written; query for the specificity its subcategory needs.

    ReviewT80.61XA, T80.61XD, T80.61XS

  2. Is the encounter phase documented — active treatment, healing or recovery, or a sequela?
    Yes → Assign the matching 7th character; the variant codes are in the 7th Character Guide.
    No → The code is invalid without its 7th character — query for the missing element.

Consider T80.61. Then work the Use Additional Code note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
Encounter type
Active treatment, healing or recovery phase, or sequela — the basis of the 7th character (Guidelines I.C.19.a).
The associated condition or complication
Whether the associated condition the title names is documented; the “with” convention presumes some links, and a provider statement that the conditions are unrelated defeats it (Guidelines I.A.15).
The conditions the Use Additional Code note names
Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.
Any detail beyond this code’s title
What the record states that a more specific sibling code would capture — or its absence, which itself supports the unspecified code.

Official instructions as workflow

  • Excludes2 — not part of T80.61(29 notes)

    Coding workflow: The conditions named in this note are not included in T80.61. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    CompareT86.01, R50.84, E87.71, D69.51, E83.111, J95.84

    See the official tabular notes · Guidelines I.A.12.b

  • Use Additional Code — after identifying T80.61(3 notes)

    Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with T80.61 when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.

    See the official tabular notes · Guidelines I.A.13

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: The patient returns during the healing or recovery phase after active treatment of the same condition.

Coding question: Which 7th character applies?

Path: Review the official 7th-character definitions for this family in the 7th Character Guide.

Reason: “Initial encounter” means active treatment, not the first visit; care during recovery takes “subsequent encounter”, and a complication arising from the original condition takes “sequela” (Guidelines I.C.19.a).

Documentation: Only one of the components this code’s title joins is documented.

Coding question: Is T80.61 supported?

Path: Review the code for the documented component on its own.

Reason: A combination code is assigned only when it fully identifies the documented conditions; otherwise the documented component takes its own code (Guidelines I.B.9).

Documentation: A condition the Use Additional Code note names is documented.

Coding question: Is a second code reported with T80.61?

Path: Review the Use Additional Code note and the code it names.

Reason: The additional code is reported when the record documents the condition; a conditional instruction applies only when its condition is met (Guidelines I.A.13).

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Other serum reaction due to administration of blood and blood products is a non-billable ICD-10-CM category code (T80.61). A more specific billable subcode must be selected for claims submission.

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (1)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Decision Points

The directives on this code's own record, as a pre-claim checklist.

  1. A 7th character applies in this family. Confirm the documented encounter matches the character assigned. See the official 7th-character definitions and this code’s variants
  2. 3 Use Additional Code instructions — report the named additional code(s) when the documentation supports them. See the Use Additional Code notes
  3. 29 Excludes2 entries — those conditions are not part of this code and may be reported additionally when documented. See the Excludes2 notes

Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.

Verify Before Coding

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name T80.61 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 5 Excludes1 notes across 2 chapters: L50 — Urticaria (via T80.6.-), L95 — Vasculitis limited to skin, not elsewhere classified (via T80.6.-), T78.3 — Angioneurotic edema (via T80.6.-), T80.5 — Anaphylactic reaction due to serum (via T80.6.-), T88.7 — Unspecified adverse effect of drug or medicament (via T80.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 6 Excludes2 notes: T45.8 — Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents (via T80.-), T78 — Adverse effects, not elsewhere classified (via T80.-), T79 — Certain early complications of trauma, not elsewhere classified (via T80.-), T81 — Complications of procedures, not elsewhere classified (via T80.-), T88 — Other complications of surgical and medical care, not elsewhere classified (via T80.-), T88.1 — Other complications following immunization, not elsewhere classified (via T80.6.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 1 Code First instruction: M36.4 — Arthropathy in hypersensitivity reactions classified elsewhere (via T80.6.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

Related Codes

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Reaction”; these codes share that main term but sit in a different category of the Tabular List.

L56.0 — Drug phototoxic response (drug NEC, phototoxic), L56.1 — Drug photoallergic response (drug NEC, photoallergic), O29.3X — Toxic reaction to local anesthesia during pregnancy (toxic, to local anesthesia, in pregnancy), O74.4 — Toxic reaction to local anesthesia during labor and delivery (toxic, to local anesthesia, in labor and delivery), O89.3 — Toxic reaction to local anesthesia during the puerperium (toxic, to local anesthesia, postpartum, puerperal), P93.0 — Grey baby syndrome (drug NEC, newborn, gray baby syndrome), P93.8 — Other reactions and intoxications due to drugs administered to newborn (drug NEC, newborn), P96.1 — Neonatal withdrawal symptoms from maternal use of drugs of addiction (drug NEC, withdrawal, newborn), R50.84 — Febrile nonhemolytic transfusion reaction (febrile nonhemolytic transfusion), R68.89 — Other general symptoms and signs (Herxheimer's), R76.11 — Nonspecific reaction to tuberculin skin test without active tuberculosis (tuberculin skin test, abnormal), R76.12 — Nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis (nonspecific, to, Quanti FERON-TB testwithout active tuberculosis), T38.3 — Poisoning by, adverse effect of and underdosing of insulin and oral hypoglycemic [antidiabetic] drugs (insulin), T78.19 — Other adverse food reactions, not elsewhere classified (adverse, food NEC), T81.60 — Unspecified acute reaction to foreign substance accidentally left during a procedure (foreign, substance accidentally left during a procedure), T81.61 — Aseptic peritonitis due to foreign substance accidentally left during a procedure (foreign, substance accidentally left during a procedure, aseptic peritonitis), T81.69 — Other acute reaction to foreign substance accidentally left during a procedure (foreign, substance accidentally left during a procedure, specified reaction NEC), T88.59 — Other complications of anesthesia (toxic, to local anesthesia), T88.7 — Unspecified adverse effect of drug or medicament (drug NEC), Z73.3 — Stress, not elsewhere classified (post-traumatic stress, uncomplicated), +31 more

Contextual Map

Every relationship of T80.61 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run T80.61 with these 12 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Excludes2 notes

Referenced by Code First instructions

Index entries

  • Reaction, serum, specified reaction NEC, due to, administration of blood and blood products[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (40)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Common coding questions

Can T80.61 be billed directly?

No. T80.61 (Other serum reaction due to administration of blood and blood products) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.

Does T80.61 require a 7th character?

Yes. The appropriate 7th character is to be added to each code from category T80.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Other serum reaction due to administration of blood and blood products

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to T80.61 in its code family, with their registry titles.

View all codes in the T80 family