P93.0 ICD-10-CM Code: Grey baby syndrome

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for P93.0 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on P93.0 itself; “inherited from” names the category or block whose note applies here.

Coder workflow for P93.0

MedCoder structured workflow — derived from this code’s own official record

Before you code P93.0

1. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with P93.0. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

   See the official tabular notes

Choose the right path

1. Does the documentation support a condition named in P93.0’s Excludes1 note?
   Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
   No → Continue.

   ReviewP58.4, P04.4, P96.1, P96.2

Consider P93.0. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement

Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Official instructions as workflow

• Excludes1 — check before selecting P93.0(4 notes)

  Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with P93.0: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

  CompareP58.4, P04.4, P96.1, P96.2

  See the official tabular notes · Guidelines I.A.12.a

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Indexed Clinical Terms (5)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

• Gray syndrome (newborn)
• Grey syndrome (newborn)
• Intoxication, drug, newborn, gray baby syndrome
• Reaction, drug NEC, newborn, gray baby syndrome
• Syndrome, gray or grey (newborn)

Don’t confuse P93.0 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of P93.0 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

• P58.4— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of jaundice due to drugs or toxins transmitted from mother or given to newborn moves the case to P58.4; the two are not reported together unless documented as unrelated.

  Full comparison: P93.0 vs P58.4 →

• P04.0— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of reactions and intoxications from maternal opiates, tranquilizers and other medication moves the case to P04.0; the two are not reported together unless documented as unrelated.

  Full comparison: P93.0 vs P04.0 →

• P04.1— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of reactions and intoxications from maternal opiates, tranquilizers and other medication moves the case to P04.1; the two are not reported together unless documented as unrelated.

  Full comparison: P93.0 vs P04.1 →

• P04.4— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of reactions and intoxications from maternal opiates, tranquilizers and other medication moves the case to P04.4; the two are not reported together unless documented as unrelated.

  Full comparison: P93.0 vs P04.4 →

• P96.1— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of withdrawal symptoms from maternal use of drugs of addiction moves the case to P96.1; the two are not reported together unless documented as unrelated.

  Full comparison: P93.0 vs P96.1 →

• P96.2— Excludes1 conflict (Excludes1 — generally not reported together)

  Not coded here — the tabular list excludes this pair for the same encounter.

  Not reported together with this code, except where the two conditions are documented as unrelated.

  What moves you there: Documentation of withdrawal symptoms from therapeutic use of drugs in newborn moves the case to P96.2; the two are not reported together unless documented as unrelated.

  Full comparison: P93.0 vs P96.2 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Verify Before Coding

• CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 4 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 2 MS-DRGs: DRG 791 (MDC 15), DRG 793 (MDC 15).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):PNL013 — Other specified and unspecified perinatal conditions (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

P93.8 — Other reactions and intoxications due to drugs administered to newborn, P96.1 — Neonatal withdrawal symptoms from maternal use of drugs of addiction, P96.2 — Withdrawal symptoms from therapeutic use of drugs in newborn

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Drug Use Disorder, Moderate/Severe, or Drug Use with Non-Psychotic Complications) for risk-adjusted payment.

P04.3 — Newborn affected by maternal use of alcohol, P04.40 — Newborn affected by maternal use of unspecified drugs of addiction, P04.41 — Newborn affected by maternal use of cocaine, P04.42 — Newborn affected by maternal use of hallucinogens, P04.49 — Newborn affected by maternal use of other drugs of addiction, P04.5 — Newborn affected by maternal use of nutritional chemical substances, P04.6 — Newborn affected by maternal exposure to environmental chemical substances, P04.81 — Newborn affected by maternal use of cannabis, P04.89 — Newborn affected by other maternal noxious substances, P04.9 — Newborn affected by maternal noxious substance, unspecified, P93.8 — Other reactions and intoxications due to drugs administered to newborn, P96.1 — Neonatal withdrawal symptoms from maternal use of drugs of addiction, P96.2 — Withdrawal symptoms from therapeutic use of drugs in newborn, R11.16 — Cannabis hyperemesis syndrome, T40.0X1A — Poisoning by opium, accidental (unintentional), initial encounter, T40.0X4A — Poisoning by opium, undetermined, initial encounter, T40.1X1A — Poisoning by heroin, accidental (unintentional), initial encounter, T40.1X4A — Poisoning by heroin, undetermined, initial encounter, T40.2X1A — Poisoning by other opioids, accidental (unintentional), initial encounter, T40.2X4A — Poisoning by other opioids, undetermined, initial encounter, +287 more

Related risk categories

These categories interact through CMS's HCC hierarchy — one can suppress the other's risk-adjustment weight when both are present on a claim.

Drug Use with Psychotic Complications, Alcohol Use with Psychotic Complications, Drug Use Disorder, Mild, Uncomplicated, Except Cannabis, Alcohol Use Disorder, Moderate/Severe, or Alcohol Use with Specified Non-Psychotic Complications

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Other specified and unspecified perinatal conditions).

P83.2 — Hydrops fetalis not due to hemolytic disease, P83.30 — Unspecified edema specific to newborn, P83.39 — Other edema specific to newborn, P83.4 — Breast engorgement of newborn, P83.5 — Congenital hydrocele, P83.6 — Umbilical polyp of newborn, P83.8 — Other specified conditions of integument specific to newborn, P83.81 — Umbilical granuloma, P83.88 — Other specified conditions of integument specific to newborn, P83.9 — Condition of the integument specific to newborn, unspecified, P93.8 — Other reactions and intoxications due to drugs administered to newborn, P94.0 — Transient neonatal myasthenia gravis, P94.1 — Congenital hypertonia, P94.2 — Congenital hypotonia, P94.8 — Other disorders of muscle tone of newborn, P94.9 — Disorder of muscle tone of newborn, unspecified, P95 — Stillbirth, P96.0 — Congenital renal failure, P96.3 — Wide cranial sutures of newborn, P96.5 — Complication to newborn due to (fetal) intrauterine procedure, +74 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Reaction”, “Intoxication”; these codes share that main term but sit in a different category of the Tabular List.

F99 — Mental disorder, not otherwise specified (psychogenic), G97.1 — Other reaction to spinal and lumbar puncture (spinal puncture), K52.1 — Toxic gastroenteritis and colitis (enteric), K76.82 — Hepatic encephalopathy (hepatocerebral), L43.2 — Lichenoid drug reaction (drug NEC, lichenoid), L56.0 — Drug phototoxic response (drug NEC, phototoxic), L56.1 — Drug photoallergic response (drug NEC, photoallergic), O29.3X — Toxic reaction to local anesthesia during pregnancy (toxic, to local anesthesia, in pregnancy), O74.4 — Toxic reaction to local anesthesia during labor and delivery (toxic, to local anesthesia, in labor and delivery), O89.3 — Toxic reaction to local anesthesia during the puerperium (toxic, to local anesthesia, postpartum, puerperal), P96.1 — Neonatal withdrawal symptoms from maternal use of drugs of addiction (drug NEC, withdrawal, newborn), R50.84 — Febrile nonhemolytic transfusion reaction (febrile nonhemolytic transfusion), R68.89 — Other general symptoms and signs (Herxheimer's), R76.11 — Nonspecific reaction to tuberculin skin test without active tuberculosis (tuberculin skin test, abnormal), R76.12 — Nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis (nonspecific, to, Quanti FERON-TB testwithout active tuberculosis), T38.3 — Poisoning by, adverse effect of and underdosing of insulin and oral hypoglycemic [antidiabetic] drugs (insulin), T78.19 — Other adverse food reactions, not elsewhere classified (adverse, food NEC), T80.39 — Other ABO incompatibility reaction due to transfusion of blood or blood products (incompatibility, ABO blood group, delayed serologic), T80.59 — Anaphylactic reaction due to other serum (serum, anaphylactic), T80.61 — Other serum reaction due to administration of blood and blood products (serum, specified reaction NEC, due to, administration of blood and blood products), +65 more

Contextual Map

Every relationship of P93.0 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

• P00-P96 — Chapter 16: Certain Conditions Originating in the Perinatal Period (P00-P96) (P00-P96)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• P90-P96 — Other disorders originating in the perinatal period[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Clinical classification (CCSR)

• PNL013 — Other specified and unspecified perinatal conditions[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)

Risk adjustment (CMS-HCC)

• HCC 137 — Drug Use Disorder, Moderate/Severe, or Drug Use with Non-Psychotic Complications [CMS-HCC]: “Drug Use Disorder, Moderate/Severe, or Drug Use with Non-Psychotic Complications — supersedes HCC 138 (Drug Use Disorder, Mild, Uncomplicated, Except Cannabis), HCC 139 (Alcohol Use Disorder, Moderate/Severe, or Alcohol Use with Specified Non-Psychotic Complications)”— CMS-HCC V28 · 2026

MS-DRG Grouper

• CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”— CMS MS-DRG Definitions Manual (Appendix C) · FY2026
• DRG 791 — PREMATURITY WITH MAJOR PROBLEMS[MS-DRG]: “PREMATURITY WITH MAJOR PROBLEMS (MDC 15)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• DRG 793 — FULL TERM NEONATE WITH MAJOR PROBLEMS[MS-DRG]: “FULL TERM NEONATE WITH MAJOR PROBLEMS (MDC 15)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026

MDC crossing

• MDC 15 — Newborns and Other Neonates with Conditions Originating in Perinatal Period[MDC crossing]: “Newborns and Other Neonates with Conditions Originating in Perinatal Period — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

• Gray syndrome (newborn)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Grey syndrome (newborn)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Intoxication, drug, newborn, gray baby syndrome[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Reaction, drug NEC, newborn, gray baby syndrome[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
• Syndrome, gray or grey (newborn)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes

• P93 — Reactions and intoxications due to drugs administered to newborn[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
• P93.8 — Other reactions and intoxications due to drugs administered to newborn[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026

Change history

• FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data

CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page

Claim edits Official source data

CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page

Inpatient payment groups Official source data

CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page

Risk adjustment Official source data

2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page

Change history and date-of-service validity Official source data

CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page

Comparisons, relationships and the contextual map MedCoder structured relationship

Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears

Summary and FAQ answers MedCoder explanation

Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Nearest Codes in This Family

Official ICD-10-CM classifications closest to P93.0 in its code family, with their registry titles.

• P93 — Reactions and intoxications due to drugs administered to newborn
• P93.8 — Other reactions and intoxications due to drugs administered to newborn

View all codes in the P93 family