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Z88.4 ICD-10-CM Code: Allergy status to anesthetic agent

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
1 Excludes2 · 1 code-also instruction

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

  • MS-DRG 951 — OTHER FACTORS INFLUENCING HEALTH STATUS (MDC 23)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for Z88.4 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on Z88.4 itself; “inherited from” names the category or block whose note applies here.

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Source: inherited from Z88

Code Also

Additional codes that may be required to fully describe the encounter.

  • any follow-up examination (Z08-Z09)

Source: inherited from Z77-Z99

Coder workflow for Z88.4

MedCoder structured workflow — derived from this code’s own official record

Before you code Z88.4

  1. Confirm the reason for the encounter this Z code records: a status — a condition, carrier state or sequela that may affect care, distinct from a current complication of it. Check whether the code may be reported as first-listed or principal — some Z codes are limited to one position — and do not report a history or status code for a condition documented as current. Z code categories and their reporting positions (Guidelines I.C.21.c.3, I.C.21.c.15).

    Guide: Status codes (Z codes) →

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
The reason for the encounter
Whether the code records the encounter’s purpose, a status, or a history — and whether it may be first-listed (Guidelines I.C.21.c).

Official instructions as workflow

  • Excludes2 — not part of Z88.4(1 note)

    Coding workflow: The conditions named in this note are not included in Z88.4. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    CompareZ91.0

    See the official tabular notes · Guidelines I.A.12.b

  • Code Also — related condition(1 note)

    Coding workflow: Review the related condition when both are documented and the instruction applies. A Code Also note does not fix sequencing; the order follows the circumstances of the encounter.

    See the official tabular notes · Guidelines I.A.17

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Allergy status to anesthetic agent is a billable ICD-10-CM diagnosis code (Z88.4).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (2)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Official Coding Guidelines

Official source data — quoted verbatim from the CMS/NCHS Official Guidelines

Official source data — quoted verbatim from the CMS/NCHS Official Guidelines

Verbatim excerpts from the ICD-10-CM Official Guidelines for Coding and Reporting (CMS/NCHS) that govern this code.

Chapter 21: Factors influencing health status and contact with health services (Z00-Z99)

Z88 Allergy status to drugs, medicaments and biological substances Except: Z88.9, Allergy status to unspecified drugs, medicaments and biological substances status Z89 Acquired absence of limb Z90 Acquired absence of organs, not elsewhere classified Z91.0- Allergy status, other than to drugs and biological substances Z92.82 Status post administration of tPA (rtPA) in a different facility within the last 24 hours prior to admission to a current facility

Verify Before Coding

  • Principal-diagnosis restriction. The Medicare Code Editor lists this code as unacceptable as a principal diagnosis: it describes a circumstance influencing health status rather than a current illness or injury being treated. It is valid as a secondary diagnosis.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name Z88.4 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 1 Excludes2 note: Z91.0 — Allergy status, other than to drugs and biological substances (via Z88.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 1 Code Also instruction: Z87.892 — Personal history of anaphylaxis (via Z88.-).

These codes suggest coding this condition alongside when both are present.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 1 MS-DRG: DRG 951 (MDC 23).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):FAC025 — Other specified status (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Principal diagnosis restriction (Medicare Code Editor)

Not acceptable as a principal diagnosis on an inpatient claim.

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Other specified status).

Z79.83 — Long term (current) use of bisphosphonates, Z79.84 — Long term (current) use of oral hypoglycemic drugs, Z79.85 — Long-term (current) use of injectable non-insulin antidiabetic drugs, Z79.890 — Hormone replacement therapy, Z79.891 — Long term (current) use of opiate analgesic, Z79.899 — Other long term (current) drug therapy, Z88.0 — Allergy status to penicillin, Z88.1 — Allergy status to other antibiotic agents, Z88.2 — Allergy status to sulfonamides, Z88.3 — Allergy status to other anti-infective agents, Z88.5 — Allergy status to narcotic agent, Z88.6 — Allergy status to analgesic agent, Z88.7 — Allergy status to serum and vaccine, Z88.8 — Allergy status to other drugs, medicaments and biological substances, Z88.9 — Allergy status to unspecified drugs, medicaments and biological substances, Z91.010 — Allergy to peanuts, Z91.011 — Allergy to milk products, Z91.0110 — Allergy to milk products, unspecified, Z91.0111 — Allergy to milk products with tolerance to baked milk, Z91.0112 — Allergy to milk products with reactivity to baked milk, +232 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “History”; these codes share that main term but sit in a different category of the Tabular List.

Z87.790 — Personal history of (corrected) congenital malformations of face and neck (personal, congenital malformation, neck), Z87.798 — Personal history of other (corrected) congenital malformations (personal, congenital malformation), Z87.81 — Personal history of (healed) traumatic fracture (personal, fracture, traumatic), Z87.820 — Personal history of traumatic brain injury (personal, brain injury), Z87.821 — Personal history of retained foreign body fully removed (personal, retained foreign body fully removed), Z87.828 — Personal history of other (healed) physical injury and trauma (personal, injury NEC), Z87.890 — Personal history of sex reassignment (personal, sex reassignment), Z87.891 — Personal history of nicotine dependence (personal, tobacco dependence), Z87.892 — Personal history of anaphylaxis (personal, anaphylaxis), Z87.898 — Personal history of other specified conditions (personal, specified NEC), Z90.710 — Acquired absence of both cervix and uterus (personal, hysterectomy), Z91.010 — Allergy to peanuts (personal, allergy, food, peanuts), Z91.0110 — Allergy to milk products, unspecified (personal, allergy, food, milk products), Z91.0111 — Allergy to milk products with tolerance to baked milk (personal, allergy, food, milk products, with, tolerance to baked milk), Z91.0112 — Allergy to milk products with reactivity to baked milk (personal, allergy, food, milk products, with, reactivity to baked milk), Z91.0120 — Allergy to eggs, unspecified (personal, allergy, food, eggs), Z91.0121 — Allergy to eggs with tolerance to baked egg (personal, allergy, food, eggs, with, tolerance to baked egg), Z91.0122 — Allergy to eggs with reactivity to baked egg (personal, allergy, food, eggs, with, reactivity to baked egg), Z91.013 — Allergy to seafood (personal, allergy, food, seafood), Z91.014 — Allergy to mammalian meats (personal, allergy, food, lamb), +257 more

Contextual Map

Every relationship of Z88.4 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run Z88.4 with these 2 related codes in Claim Check

Hierarchy

Referenced by Excludes2 notes

Referenced by Code Also instructions

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 23 — Factors Influencing Health Status and Other Contacts with Health Services[MDC crossing]: “Factors Influencing Health Status and Other Contacts with Health Services — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 1,235 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

  • History, personal (of), allergy (to), anesthetic[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • History, personal (of), hyperthermia, malignant[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (10)

Change history (3)

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Coding guidelines Official source data
ICD-10-CM Official Guidelines for Coding and Reporting (FY2026), quoted by section Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "Z88.4 — Allergy status to anesthetic agent." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/z88.4-allergy-status-to-anesthetic-agent

Change history

  • FY2021 — October 1, 2020
    Description revised
    Allergy status to anesthetic agent status → Allergy status to anesthetic agent
    FY2021 changes
  • FY2021 — October 1, 2020
    Short description revised
    Allergy status to anesthetic agent status → Allergy status to anesthetic agent
    FY2021 changes
  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Allergy status to anesthetic agent status

Nearest Codes in This Family

Official ICD-10-CM classifications closest to Z88.4 in its code family, with their registry titles.

View all codes in the Z88 family