546 MS-DRG: CONNECTIVE TISSUE DISORDERS WITH CC
MS-DRG 546 groups Medicare inpatient hospital stays for: CONNECTIVE TISSUE DISORDERS WITH CC. This is a medical MS-DRG. It falls under MDC 08 (Diseases and Disorders of the Musculoskeletal System and Connective Tissue).
Payment & Classification Data
Official CMS values from the FY2027 IPPS Final Rule Table 5.
| Major Diagnostic Category | MDC 08 — Diseases and Disorders of the Musculoskeletal System and Connective Tissue |
| DRG Type | Medical |
| Severity Level | CC |
| Relative Weight | 1.1745 |
| Relative Weight (10% Cap Applied) | 1.1745 |
| Geometric Mean Length of Stay | 3.3 days |
| Arithmetic Mean Length of Stay | 4.3 days |
| Post-Acute Transfer DRG | Yes |
| Special Pay Transfer DRG | No |
Defining Codes (FY2027)
562 diagnosis codes can drive assignment here: D89.82, E85.0, E85.1, E85.2, E85.3, E85.4, E85.81, E85.82, E85.89, E85.9, G72.41, G72.49 and 550 more.
From the CMS MS-DRG Definitions Manual (Appendices B and E). Assignment also depends on severity, discharge status and the rest of the claim.
Contextual Map
Every relationship of 546 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.
Major Diagnostic Category
- MDC 08 — Diseases and Disorders of the Musculoskeletal System and Connective Tissue[MDC]— CMS MS-DRG Definitions Manual · FY2027
Defining diagnoses (562)
- D89.82 — Autoimmune lymphoproliferative syndrome [ALPS][Grouper diagnosis]— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
- E85.0 — Non-neuropathic heredofamilial amyloidosis[Grouper diagnosis]— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
- E85.1 — Neuropathic heredofamilial amyloidosis[Grouper diagnosis]— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
- E85.2 — Heredofamilial amyloidosis, unspecified[Grouper diagnosis]— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
- E85.3 — Secondary systemic amyloidosis[Grouper diagnosis]— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
- E85.4 — Organ-limited amyloidosis[Grouper diagnosis]— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
- E85.81 — Light chain (AL) amyloidosis[Grouper diagnosis]— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
- E85.82 — Wild-type transthyretin-related (ATTR) amyloidosis[Grouper diagnosis]— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
- and 554 more
DRG family
- DRG 545 — CONNECTIVE TISSUE DISORDERS WITH MCC[DRG family]: “CONNECTIVE TISSUE DISORDERS WITH MCC — same CMS DRG family (545-547), split by severity.”— CMS MS-DRG Definitions Manual (DRG family 545-547) · FY2027
- DRG 547 — CONNECTIVE TISSUE DISORDERS WITHOUT CC/MCC[DRG family]: “CONNECTIVE TISSUE DISORDERS WITHOUT CC/MCC — same CMS DRG family (545-547), split by severity.”— CMS MS-DRG Definitions Manual (DRG family 545-547) · FY2027
Read from: CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44. All data sources · How to read the labels