Alka-Seltzer Plus Severe Cold PowerFast Fizz

NDC 0280-0020 · Bayer HealthCare LLC.

Generic nameaspirin, chlorpheniramine maleate, phenylephrine bitartrate

Dosage formTABLET, EFFERVESCENT

RouteORAL

Active ingredient(s)PHENYLEPHRINE BITARTRATE, CHLORPHENIRAMINE MALEATE, ASPIRIN

Strength325; 2; 7 mg/1; mg/1; mg/1

Pharmacologic classAdrenergic alpha1-Agonists [MoA], Anti-Inflammatory Agents, Non-Steroidal [CS], Cyclooxygenase Inhibitors [MoA], Decreased Platelet Aggregation [PE], Decreased Prostaglandin Production [PE], Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC], Nonsteroidal Anti-inflammatory Drug [EPC], Platelet Aggregation Inhibitor [EPC], alpha-1 Adrenergic Agonist [EPC]

Marketing categoryOTC MONOGRAPH DRUG

Packages

0280-0020-01 — 10 POUCH in 1 CARTON (0280-0020-01) / 2 TABLET, EFFERVESCENT in 1 POUCH

0280-0020-02 — 12 POUCH in 1 CARTON (0280-0020-02) / 2 TABLET, EFFERVESCENT in 1 POUCH

Related Codes

Same active ingredient

FDA lists these products with the same active ingredient.

0067-8202 — Acetaminophen, Aspirin (NSAID), and Caffeine, 0067-8203 — Acetaminophen, Aspirin (NSAID), and Caffeine, 0067-8205 — Acetaminophen, Chlorpheniramine maleate, Dextromethorphan HBr, 0113-0274 — Aspirin, 0113-0374 — Acetaminophen, Aspirin, Caffeine, 0113-0467 — Aspirin, 0113-1619 — acetaminophen, aspirin, caffeine, 0113-1855 — acetaminophen, aspirin, caffeine, 0135-0578 — acetaminophen, chlorpheniramine maleate, phenylephrine hcl, 0135-7034 — acetaminophen, chlorpheniramine maleate, dextromethorphan HBr, 0280-0021 — aspirin, dextromethorphan hydrobromide, doxylamine succinate, phenylephrine bitartrate, 0280-0023 — aspirin, chlorpheniramine maleate, dextromethorphan hydrobromide, phenylephrine bitartrate, 0280-0024 — asprin, dextromethorphan hydrobromide, phenylephrine bitartrate, 0280-0055 — chlorpheniramine maleate, dextromethorphan hydrobromide, acetaminophen, phenylephrine hydrochloride, 0280-0060 — aspirin, chlorpheniramine maleate, phenylephrine bitartrate, 0280-0064 — Aspirin and caffeine, 0280-0068 — aspirin, doxylamine succinate, dextromethorphan hydrobromide, phenylephrine bitartrate, 0280-0084 — ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE, 0280-0087 — Alka-Seltzer Original Flavor, 0280-0088 — chlorpheniramine maleate, acetaminophen, phenylephrine hydrochloride, dextromethorphan hydrobromide, +960 more

From the FDA National Drug Code Directory, retrieved August 24, 2026. Product listings are submitted by labelers; FDA does not verify them.

Read from: FDA National Drug Code Directory, product.txt and package.txt (accessdata.fda.gov/cder/ndctext.zip) — Snapshot retrieved 2026-08-24, loaded 2026-08-24; CMS Medicare Part B Drug Average Sales Price (ASP) Pricing Files (cms.gov/medicare/payment/part-b-drugs/asp-pricing-files) -- the NDC-HCPCS crosswalk and Part B payment limit files — 2026 Q3 (July 2026 release). All data sources · How to read the labels