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Alka-Seltzer Plus Maximum Strength Sinus Congestion and Pain PowerFast Fizz

NDC 0280-0055 · Bayer HealthCare LLC.

Generic namechlorpheniramine maleate, dextromethorphan hydrobromide, acetaminophen, phenylephrine hydrochloride
Dosage formTABLET, EFFERVESCENT
RouteORAL
Active ingredient(s)CHLORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE, ACETAMINOPHEN
Strength325; 2; 10; 5 mg/1; mg/1; mg/1; mg/1
Pharmacologic classAdrenergic alpha1-Agonists [MoA], Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC], Sigma-1 Agonist [EPC], Sigma-1 Receptor Agonists [MoA], Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC], Uncompetitive NMDA Receptor Antagonists [MoA], alpha-1 Adrenergic Agonist [EPC]
Marketing categoryOTC MONOGRAPH DRUG

Packages

0280-0055-01 — 10 POUCH in 1 CARTON (0280-0055-01) / 2 TABLET, EFFERVESCENT in 1 POUCH

0280-0055-02 — 12 POUCH in 1 CARTON (0280-0055-02) / 2 TABLET, EFFERVESCENT in 1 POUCH

Related Codes

Same active ingredient

FDA lists these products with the same active ingredient.

0225-0811 — PHENYLEPHRINE HYDROCHLORIDE, 0245-0410 — Hydrocodone Bitartrate and Acetaminophen, 0245-0411 — Hydrocodone Bitartrate and Acetaminophen, 0245-0412 — Hydrocodone Bitartrate and Acetaminophen, 0264-4050 — Acetaminophen, 0264-4100 — Acetaminophen, 0280-0020 — aspirin, chlorpheniramine maleate, phenylephrine bitartrate, 0280-0021 — aspirin, dextromethorphan hydrobromide, doxylamine succinate, phenylephrine bitartrate, 0280-0023 — aspirin, chlorpheniramine maleate, dextromethorphan hydrobromide, phenylephrine bitartrate, 0280-0024 — asprin, dextromethorphan hydrobromide, phenylephrine bitartrate, 0280-0060 — aspirin, chlorpheniramine maleate, phenylephrine bitartrate, 0280-0061 — acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride, 0280-0068 — aspirin, doxylamine succinate, dextromethorphan hydrobromide, phenylephrine bitartrate, 0280-0078 — ACETAMINOPHEN, CAFFEINE, and PYRILAMINE MALEATE, 0280-0088 — chlorpheniramine maleate, acetaminophen, phenylephrine hydrochloride, dextromethorphan hydrobromide, 0280-0089 — dextromethorphan hydrobromide, guaifenesin, 0280-0092 — Acetaminophen, Chlorpheniramine malaeate, Dextromethorphan hydrobromide, Phenylephrine hydrochloride, 0280-0095 — Acetaminophen, Dextromethorphan hydrobromide , Phenylephrine hydrochloride, 0280-0097 — Acetaminophen, Dextromethorphan hydrobromide , Doxylamine Succinate, Phenylephrine hydrochloride, 0280-0121 — aspirin, chlorpheniramine maleate, dextromethorphan hydrobromide, phenylephrine bitartrate, +4944 more

From the FDA National Drug Code Directory, retrieved August 24, 2026. Product listings are submitted by labelers; FDA does not verify them.

Read from: FDA National Drug Code Directory, product.txt and package.txt (accessdata.fda.gov/cder/ndctext.zip) — Snapshot retrieved 2026-08-24, loaded 2026-08-24; CMS Medicare Part B Drug Average Sales Price (ASP) Pricing Files (cms.gov/medicare/payment/part-b-drugs/asp-pricing-files) -- the NDC-HCPCS crosswalk and Part B payment limit files — 2026 Q3 (July 2026 release). All data sources · How to read the labels