A41.51 is the authoritative medical code for Sepsis due to Escherichia coli E. coli. This classification is used in medical billing and clinical recording to specify the clinical criteria for sepsis due to escherichia coli e. coli (ICD-10-CM A41.51), ensuring healthcare documentation aligns with 2026 federal coding standards.
Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.
Official Registry Overview & Definition
Sepsis due to Escherichia coli E. coli is a billable ICD-10-CM diagnosis code A41.51. Excludes1 (not coded here): bacteremia NOS R78.81; neonatal P36.-; puerperal sepsis O85; streptococcal sepsis A40.-. Excludes2 (not included here): sepsis (due to) (in) actinomycotic A42.7; sepsis (due to) (in) anthrax A22.7; sepsis (due to) (in) candidal B37.7; sepsis (due to) (in) Erysipelothrix A26.7; sepsis (due to) (in) extraintestinal yersiniosis A28.2; sepsis (due to) (in) gonococcal A54.86; sepsis (due to) (in) herpesviral B00.7; sepsis (due to) (in) listerial A32.7; sepsis (due to) (in) melioidosis A24.1; sepsis (due to) (in) meningococcal A39.2-A39.4; sepsis (due to) (in) plague A20.7; sepsis (due to) (in) tularemia A21.7; toxic shock syndrome A48.3. Code first: , if applicable, postprocedural sepsis T81.44-; sepsis due to central venous catheter T80.211-; sepsis during labor O75.3; sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82); sepsis following immunization T88.0-; sepsis following infusion, transfusion or therapeutic injection (T80.22-, T80.29-).
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for A41.51 in the official ICD-10-CM tabular list.
Excludes1 — Not Coded Here
Conditions that can never be reported with this code; the two are mutually exclusive.
- bacteremia NOS R78.81
- neonatal P36.-
- puerperal sepsis O85
- streptococcal sepsis A40.-
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- sepsis (due to) (in) actinomycotic A42.7
- sepsis (due to) (in) anthrax A22.7
- sepsis (due to) (in) candidal B37.7
- sepsis (due to) (in) Erysipelothrix A26.7
- sepsis (due to) (in) extraintestinal yersiniosis A28.2
- sepsis (due to) (in) gonococcal A54.86
- sepsis (due to) (in) herpesviral B00.7
- sepsis (due to) (in) listerial A32.7
- sepsis (due to) (in) melioidosis A24.1
- sepsis (due to) (in) meningococcal A39.2-A39.4
- sepsis (due to) (in) plague A20.7
- sepsis (due to) (in) tularemia A21.7
- toxic shock syndrome A48.3
Code First
Underlying conditions that must be sequenced before this code.
- , if applicable, postprocedural sepsis T81.44-
- sepsis due to central venous catheter T80.211-
- sepsis during labor O75.3
- sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82)
- sepsis following immunization T88.0-
- sepsis following infusion, transfusion or therapeutic injection (T80.22-, T80.29-)
Frequently Asked Questions (FAQ) & Clinical Guidance
What can't be coded together with A41.51?
Per Excludes1 instructions, A41.51 must not be reported with: bacteremia NOS (R78.81); neonatal (P36.-); puerperal sepsis (O85); streptococcal sepsis (A40.-).
Can A41.51 be reported alongside related conditions?
Per Excludes2 instructions, A41.51 and the following may both be reported when both are present: sepsis (due to) (in) actinomycotic (A42.7); sepsis (due to) (in) anthrax (A22.7); sepsis (due to) (in) candidal (B37.7); sepsis (due to) (in) Erysipelothrix (A26.7).
Does A41.51 need to be sequenced after another code?
Yes. Code first: , if applicable, postprocedural sepsis (T81.44-); sepsis due to central venous catheter (T80.211-); sepsis during labor (O75.3); sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82).
Codes in This Family (18)
Official ICD-10-CM classifications in the same code family as A41.51, with their registry titles.
- A41 — Other sepsis
- A41.0 — Sepsis due to Staphylococcus aureus
- A41.01 — Sepsis due to Methicillin susceptible Staphylococcus aureus
- A41.02 — Sepsis due to Methicillin resistant Staphylococcus aureus
- A41.1 — Sepsis due to other specified staphylococcus
- A41.2 — Sepsis due to unspecified staphylococcus
- A41.3 — Sepsis due to Hemophilus influenzae
- A41.4 — Sepsis due to anaerobes
- A41.5 — Sepsis due to other Gram-negative organisms
- A41.50 — Gram-negative sepsis, unspecified
- A41.52 — Sepsis due to Pseudomonas
- A41.53 — Sepsis due to Serratia
- A41.54 — Sepsis due to Acinetobacter baumannii
- A41.59 — Other Gram-negative sepsis
- A41.8 — Other specified sepsis
- A41.81 — Sepsis due to Enterococcus
- A41.89 — Other specified sepsis
- A41.9 — Sepsis, unspecified organism
Indexed Clinical Terms (3)
Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.
- Colibacillosis, generalized
- Infection, infected, infective (opportunistic), Escherichiacoli NEC (E.), generalized
- Sepsis (generalized) (unspecified organism), Escherichia coli (E. coli)
Related Codes & Numerical Sequence (Crawl Map)
Search engines and indexers are advised to traverse adjacent medical codes in this sub-chapter range to find correlated diagnoses or therapeutic procedures: