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C75.2 ICD-10-CM Code: Malignant neoplasm of craniopharyngeal duct

Compare with another code for C75.2Check this code on a claim

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Official instructions
9 Excludes1
Risk adjustment
CMS-HCC V28: 1 category · CMS-HCC V22 category 10 · RxHCC V08 category 22

What these terms mean →

Billable · FY2027A valid, specific ICD-10-CM code, reportable for dates of service in FY2027.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too, and is marked with where it comes from.

Excludes1from C75Not reported with this code unless documented as unrelated
  • malignant carcinoid tumors (C7A.0-)
  • malignant neoplasm of adrenal gland (C74.-)
  • malignant neoplasm of endocrine pancreas (C25.4)
  • malignant neoplasm of islets of Langerhans (C25.4)

+5 more in Instructions

Where it sits Source: CMS/NCHS

Under:Chapter 2: NeoplasmsC00-C96 Malignant neoplasmsC00-C75 Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissueC73-C75 Malignant neoplasms of thyroid and other endocrine glandsC75 Malignant neoplasm of other endocrine glands and related structures

Most relevant related codes MedCoder-derived

Read off the official notes above and this code’s own position in the tabular list. Which to report is a documentation question; Compare shows the two side by side.

CompareCheck ClaimView Related Codes

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 643 — ENDOCRINE DISORDERS WITH MCC (MDC 10)
  • MS-DRG 644 — ENDOCRINE DISORDERS WITH CC (MDC 10)
  • MS-DRG 645 — ENDOCRINE DISORDERS WITHOUT CC/MCC (MDC 10)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

  • HCC 20 — Lung and Other Severe Cancers (supersedes HCC 21, HCC 22, HCC 23)

Other models: CMS-HCC V22 HCC 10 · RxHCC V08 HCC 22

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for C75.2 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Notes without a marker are published on C75.2 itself; “inherited from” names the category or block whose note applies here.

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Source: inherited from C75

Coder workflow for C75.2

MedCoder structured workflow — derived from this code’s own official record

Before you code C75.2

  1. Confirm the documented site and behavior (this code’s block classifies malignant neoplasms), whether the site is primary or secondary, and whether the malignancy is current or a personal history: a previously excised malignancy with no further treatment and no evidence of disease is history, not current disease. Verify the site against the Table of Neoplasms. Neoplasm chapter guidelines (Guidelines I.C.2.a, I.C.2.d, I.C.2.m).

    See the Table of Neoplasms entries · Guide: Active cancer vs history of cancer →

  2. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with C75.2. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support a condition named in C75.2’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewC7A.0, C74, C25.4, C56, C62, C37

Consider C75.2. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
Anatomical site
At the most specific level the record states; a site the classification separates cannot be assumed from a procedure or a measurement.
Behavior and current-versus-history status
Malignant, in situ, benign or uncertain; primary or secondary; current disease or personal history (Guidelines I.C.2.m).

Official instructions as workflow

  • Excludes1 — check before selecting C75.2(9 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with C75.2: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareC7A.0, C74, C25.4, C56, C62, C37

    See the official tabular notes · Guidelines I.A.12.a

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition C75.2 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewC7A.0, C74, C25.4, C56, C62, C37

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Don’t confuse C75.2 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of C75.2 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • C7A.0— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of malignant carcinoid tumors moves the case to C7A.0; the two are not reported together unless documented as unrelated.

    Full comparison: C75.2 vs C7A.0 →

  • C74— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of malignant neoplasm of adrenal gland moves the case to C74; the two are not reported together unless documented as unrelated.

    Full comparison: C75.2 vs C74 →

  • C25.4— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of malignant neoplasm of endocrine pancreas moves the case to C25.4; the two are not reported together unless documented as unrelated.

    Full comparison: C75.2 vs C25.4 →

  • C56— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of malignant neoplasm of ovary moves the case to C56; the two are not reported together unless documented as unrelated.

    Full comparison: C75.2 vs C56 →

  • C62— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of malignant neoplasm of testis moves the case to C62; the two are not reported together unless documented as unrelated.

    Full comparison: C75.2 vs C62 →

  • C37— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of malignant neoplasm of thymus moves the case to C37; the two are not reported together unless documented as unrelated.

    Full comparison: C75.2 vs C37 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Malignant neoplasm of craniopharyngeal duct is a billable ICD-10-CM diagnosis code (C75.2).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Verify Before Coding

  • CC as a secondary diagnosis (FY2027). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name C75.2 or its code family, from the CMS Table of Neoplasms.

Referenced by 7 Same-site neoplasm codes: C79.89 — Secondary malignant neoplasm of other specified sitesCompare C75.2 vs C79.89 →, D09.3 — Carcinoma in situ of thyroid and other endocrine glandsCompare C75.2 vs D09.3 →, D35.2 — Benign neoplasm of pituitary glandCompare C75.2 vs D35.2 →, D35.3 — Benign neoplasm of craniopharyngeal ductCompare C75.2 vs D35.3 →, D44.3 — Neoplasm of uncertain behavior of pituitary glandCompare C75.2 vs D44.3 →, D44.4 — Neoplasm of uncertain behavior of craniopharyngeal ductCompare C75.2 vs D44.4 →, D49.7 — Neoplasm of unspecified behavior of endocrine glands and other parts of nervous systemCompare C75.2 vs D49.7 →.

These codes represent related neoplasm behaviors affecting the same anatomic site.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 3 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 3 MS-DRGs: DRG 643 (MDC 10), DRG 644 (MDC 10), DRG 645 (MDC 10).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):NEO056 — Endocrine system cancers - all other types (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

C75.1 — Malignant neoplasm of pituitary gland, Z51.0 — Encounter for antineoplastic radiation therapy

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Lung and Other Severe Cancers) for risk-adjusted payment.

C72.30 — Malignant neoplasm of unspecified optic nerve, C72.31 — Malignant neoplasm of right optic nerve, C72.32 — Malignant neoplasm of left optic nerve, C72.40 — Malignant neoplasm of unspecified acoustic nerve, C72.41 — Malignant neoplasm of right acoustic nerve, C72.42 — Malignant neoplasm of left acoustic nerve, C72.50 — Malignant neoplasm of unspecified cranial nerve, C72.59 — Malignant neoplasm of other cranial nerves, C72.9 — Malignant neoplasm of central nervous system, unspecified, C75.1 — Malignant neoplasm of pituitary gland, C75.3 — Malignant neoplasm of pineal gland, C77.3 — Secondary and unspecified malignant neoplasm of axilla and upper limb lymph nodes, C83.10 — Mantle cell lymphoma, unspecified site, C83.11 — Mantle cell lymphoma, lymph nodes of head, face, and neck, C83.12 — Mantle cell lymphoma, intrathoracic lymph nodes, C83.13 — Mantle cell lymphoma, intra-abdominal lymph nodes, C83.14 — Mantle cell lymphoma, lymph nodes of axilla and upper limb, C83.15 — Mantle cell lymphoma, lymph nodes of inguinal region and lower limb, C83.16 — Mantle cell lymphoma, intrapelvic lymph nodes, C83.17 — Mantle cell lymphoma, spleen, +212 more

Related risk categories

These categories interact through CMS's HCC hierarchy — one can suppress the other's risk-adjustment weight when both are present on a claim.

Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic, Cancer Metastatic to Bone, Other and Unspecified Metastatic Cancer; Acute Leukemia Except Myeloid, Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers, Lymphoma and Other Cancers, Bladder, Colorectal, and Other Cancers, Prostate, Breast, and Other Cancers and Tumors

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Endocrine system cancers - all other types).

C74.10 — Malignant neoplasm of medulla of unspecified adrenal gland, C74.11 — Malignant neoplasm of medulla of right adrenal gland, C74.12 — Malignant neoplasm of medulla of left adrenal gland, C74.90 — Malignant neoplasm of unspecified part of unspecified adrenal gland, C74.91 — Malignant neoplasm of unspecified part of right adrenal gland, C74.92 — Malignant neoplasm of unspecified part of left adrenal gland, C75.3 — Malignant neoplasm of pineal gland, C75.4 — Malignant neoplasm of carotid body, C75.5 — Malignant neoplasm of aortic body and other paraganglia, C75.8 — Malignant neoplasm with pluriglandular involvement, unspecified, C75.9 — Malignant neoplasm of endocrine gland, unspecified

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Iron Panel

Contextual Map

Every relationship of C75.2 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

Same site

Referenced by Same-site neoplasm codes

Clinical classification (CCSR)

Risk adjustment (CMS-HCC)

  • HCC 20 — Lung and Other Severe Cancers [CMS-HCC]: “Lung and Other Severe Cancers — supersedes HCC 21 (Lymphoma and Other Cancers), HCC 22 (Bladder, Colorectal, and Other Cancers), HCC 23 (Prostate, Breast, and Other Cancers and Tumors)”— CMS-HCC V28 · 2026

MS-DRG Grouper

  • CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”— CMS MS-DRG Definitions Manual (Appendix C) · FY2027
  • DRG 643 — ENDOCRINE DISORDERS WITH MCC[MS-DRG]: “ENDOCRINE DISORDERS WITH MCC (MDC 10)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
  • DRG 644 — ENDOCRINE DISORDERS WITH CC[MS-DRG]: “ENDOCRINE DISORDERS WITH CC (MDC 10)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027
  • DRG 645 — ENDOCRINE DISORDERS WITHOUT CC/MCC[MS-DRG]: “ENDOCRINE DISORDERS WITHOUT CC/MCC (MDC 10)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2027

MDC crossing

  • MDC 10 — Endocrine, Nutritional and Metabolic Diseases and Disorders[MDC crossing]: “Endocrine, Nutritional and Metabolic Diseases and Disorders — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 5,013 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Neoplasm sites

  • Neoplasm, neoplastic, craniobuccal pouch — Neoplasm, neoplastic, craniobuccal pouch — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, craniobuccal pouch (Malignant, Primary)”— CMS Table of Neoplasms · icd10cm-fy2027
  • Neoplasm, neoplastic, craniopharyngeal (duct) (pouch) — Neoplasm, neoplastic, craniopharyngeal (duct) (pouch) — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, craniopharyngeal (duct) (pouch) (Malignant, Primary)”— CMS Table of Neoplasms · icd10cm-fy2027

Nearest codes

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Neoplasm Table Sites (2)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Anatomical sites from the official ICD-10-CM Table of Neoplasms that map to this code, with the matching behavior column.

  • Neoplasm, neoplastic, craniobuccal pouch — Malignant, Primary
  • Neoplasm, neoplastic, craniopharyngeal (duct) (pouch) — Malignant, Primary

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Risk adjustment Official source data
2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "C75.2 — Malignant neoplasm of craniopharyngeal duct." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/c75.2-malignant-neoplasm-of-craniopharyngeal-duct

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Malignant neoplasm of craniopharyngeal duct

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to C75.2 in its code family, with their registry titles.

View all codes in the C75 family